Comparison of the Efficacy of Midazolam and Dexmedetomidine As Sedative Agents in Third Molar Surgery
Introduction Minor dental and oral surgical procedures have been made comfortable with the rise in the use of daycare sedatives. Of these sedatives, midazolam is deemed a common sedative used for minor oral surgical procedures. Newer and safer sedatives such as dexmedetomidine have certain propertie...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2023-11, Vol.15 (11), p.e49477-e49477 |
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| description | Introduction Minor dental and oral surgical procedures have been made comfortable with the rise in the use of daycare sedatives. Of these sedatives, midazolam is deemed a common sedative used for minor oral surgical procedures. Newer and safer sedatives such as dexmedetomidine have certain properties that may prove more efficient in oral surgical procedures. Third molar surgery is one of the most common minor oral surgical procedures performed in dentistry. Thus, this study aims to compare the efficacy of midazolam and dexmedetomidine as sedative agents in third molar surgery. Materials and methods Sixty young adult patients free from other comorbidities were included in the study with ages ranging between 18 and 50 years. The samples were matched for the difficulty of impacted teeth and randomly distributed among the groups. Groups were administered the respective sedative drugs midazolam and dexmedetomidine and their effects were observed through the Observer's Assessment of Alertness/Sedation scale. The intraoperative vitals and sedation effects were checked every 15 minutes. Statistical analysis was done using IBM SPSS Statistics for Windows, Version 22 (Released 2013; IBM Corp., Armonk, New York, United States). Independent samples t-test and analysis of variance were the statistical tests employed to analyze the obtained data with p |
| doi_str_mv | 10.7759/cureus.49477 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10753092</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2908124558</sourcerecordid><originalsourceid>FETCH-LOGICAL-c300t-6ee0c829b599512f6bba9c046d907e480ce0583b7685cf8e123232bdb1a6105d3</originalsourceid><addsrcrecordid>eNpdkUFP3DAQhS1UBGjh1nNlqZceujBO4tg-VWgLLRKoB-jZcuzJrlESb-0Edfvr8bIUAfJhxprPT2_8CPnI4FQIrs7sFHFKp5WqhNgjRwWr5VwyWX141R-Sk5TuAYCBKEDAATksJeM1E3BEcBH6tYk-hYGGlo4rpBdt662xm-39xjvzL3Smp2Zw9Dv-7dHhGHrv_ID0PNFbdGb0D7lf4jAm6gd6t_LR0Zv8KtLbKS4xbo7Jfmu6hCfPdUZ-X17cLX7Or3_9uFqcX89tCTDOa0SwslANV4qzoq2bxigLVe0UCKwkWAQuy0bUkttWIivKfBrXMFMz4K6ckW873fXUZKc2W4qm0-voexM3Ohiv304Gv9LL8KDz1_ASVJEVvjwrxPBnwjTq3ieLXWcGDFPShQLJiopnGzPy-R16H6Y45P2eKKgFlFvq646yMaQUsX1xw0BvM9S7DPVThhn_9HqDF_h_YuUjvV2YsA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2908067038</pqid></control><display><type>article</type><title>Comparison of the Efficacy of Midazolam and Dexmedetomidine As Sedative Agents in Third Molar Surgery</title><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Jason, Alden S ; Sundaram, Gidean A ; J, Preethi ; Kumar, Santhosh P ; Krishnan, Murugesan</creator><creatorcontrib>Jason, Alden S ; Sundaram, Gidean A ; J, Preethi ; Kumar, Santhosh P ; Krishnan, Murugesan</creatorcontrib><description>Introduction Minor dental and oral surgical procedures have been made comfortable with the rise in the use of daycare sedatives. Of these sedatives, midazolam is deemed a common sedative used for minor oral surgical procedures. Newer and safer sedatives such as dexmedetomidine have certain properties that may prove more efficient in oral surgical procedures. Third molar surgery is one of the most common minor oral surgical procedures performed in dentistry. Thus, this study aims to compare the efficacy of midazolam and dexmedetomidine as sedative agents in third molar surgery. Materials and methods Sixty young adult patients free from other comorbidities were included in the study with ages ranging between 18 and 50 years. The samples were matched for the difficulty of impacted teeth and randomly distributed among the groups. Groups were administered the respective sedative drugs midazolam and dexmedetomidine and their effects were observed through the Observer's Assessment of Alertness/Sedation scale. The intraoperative vitals and sedation effects were checked every 15 minutes. Statistical analysis was done using IBM SPSS Statistics for Windows, Version 22 (Released 2013; IBM Corp., Armonk, New York, United States). Independent samples t-test and analysis of variance were the statistical tests employed to analyze the obtained data with p<0.05 considered as statistically significant. Results The depth of sedation has been both subjectively and objectively assessed and had no significant difference among the groups. The intra-operative heart rate assessment proved a more efficient reduction of pulse rate in the dexmedetomidine group as compared with the midazolam group. However, it was not statistically significant (p=0.121). The mean diastolic blood pressure showed a statistically significant difference between the groups with dexmedetomidine having lower blood diastolic pressure compared to midazolam (p=0.004). Quick arousal was witnessed in the dexmedetomidine group. Conclusion It can be concluded from the study that both dexmedetomidine and midazolam were equally effective as sedative agents for third molar surgery. However, the nature of cardio-protection, anti-sialagogue, and analgesic properties of dexmedetomidine can prove helpful, especially in minor oral surgical procedures like third molar surgery and it is recommended.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.49477</identifier><identifier>PMID: 38156170</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Anesthesia ; Anesthesiology ; Anxiety ; Blood pressure ; Heart rate ; Independent sample ; Pain Management ; Patients ; Sample size ; Statistical analysis ; Surgeons ; Surgery ; Teeth ; Therapeutics ; Variance analysis</subject><ispartof>Curēus (Palo Alto, CA), 2023-11, Vol.15 (11), p.e49477-e49477</ispartof><rights>Copyright © 2023, Jason et al.</rights><rights>Copyright © 2023, Jason et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2023, Jason et al. 2023 Jason et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c300t-6ee0c829b599512f6bba9c046d907e480ce0583b7685cf8e123232bdb1a6105d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10753092/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10753092/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38156170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jason, Alden S</creatorcontrib><creatorcontrib>Sundaram, Gidean A</creatorcontrib><creatorcontrib>J, Preethi</creatorcontrib><creatorcontrib>Kumar, Santhosh P</creatorcontrib><creatorcontrib>Krishnan, Murugesan</creatorcontrib><title>Comparison of the Efficacy of Midazolam and Dexmedetomidine As Sedative Agents in Third Molar Surgery</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Introduction Minor dental and oral surgical procedures have been made comfortable with the rise in the use of daycare sedatives. Of these sedatives, midazolam is deemed a common sedative used for minor oral surgical procedures. Newer and safer sedatives such as dexmedetomidine have certain properties that may prove more efficient in oral surgical procedures. Third molar surgery is one of the most common minor oral surgical procedures performed in dentistry. Thus, this study aims to compare the efficacy of midazolam and dexmedetomidine as sedative agents in third molar surgery. Materials and methods Sixty young adult patients free from other comorbidities were included in the study with ages ranging between 18 and 50 years. The samples were matched for the difficulty of impacted teeth and randomly distributed among the groups. Groups were administered the respective sedative drugs midazolam and dexmedetomidine and their effects were observed through the Observer's Assessment of Alertness/Sedation scale. The intraoperative vitals and sedation effects were checked every 15 minutes. Statistical analysis was done using IBM SPSS Statistics for Windows, Version 22 (Released 2013; IBM Corp., Armonk, New York, United States). Independent samples t-test and analysis of variance were the statistical tests employed to analyze the obtained data with p<0.05 considered as statistically significant. Results The depth of sedation has been both subjectively and objectively assessed and had no significant difference among the groups. The intra-operative heart rate assessment proved a more efficient reduction of pulse rate in the dexmedetomidine group as compared with the midazolam group. However, it was not statistically significant (p=0.121). The mean diastolic blood pressure showed a statistically significant difference between the groups with dexmedetomidine having lower blood diastolic pressure compared to midazolam (p=0.004). Quick arousal was witnessed in the dexmedetomidine group. Conclusion It can be concluded from the study that both dexmedetomidine and midazolam were equally effective as sedative agents for third molar surgery. However, the nature of cardio-protection, anti-sialagogue, and analgesic properties of dexmedetomidine can prove helpful, especially in minor oral surgical procedures like third molar surgery and it is recommended.</description><subject>Anesthesia</subject><subject>Anesthesiology</subject><subject>Anxiety</subject><subject>Blood pressure</subject><subject>Heart rate</subject><subject>Independent sample</subject><subject>Pain Management</subject><subject>Patients</subject><subject>Sample size</subject><subject>Statistical analysis</subject><subject>Surgeons</subject><subject>Surgery</subject><subject>Teeth</subject><subject>Therapeutics</subject><subject>Variance analysis</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkUFP3DAQhS1UBGjh1nNlqZceujBO4tg-VWgLLRKoB-jZcuzJrlESb-0Edfvr8bIUAfJhxprPT2_8CPnI4FQIrs7sFHFKp5WqhNgjRwWr5VwyWX141R-Sk5TuAYCBKEDAATksJeM1E3BEcBH6tYk-hYGGlo4rpBdt662xm-39xjvzL3Smp2Zw9Dv-7dHhGHrv_ID0PNFbdGb0D7lf4jAm6gd6t_LR0Zv8KtLbKS4xbo7Jfmu6hCfPdUZ-X17cLX7Or3_9uFqcX89tCTDOa0SwslANV4qzoq2bxigLVe0UCKwkWAQuy0bUkttWIivKfBrXMFMz4K6ckW873fXUZKc2W4qm0-voexM3Ohiv304Gv9LL8KDz1_ASVJEVvjwrxPBnwjTq3ieLXWcGDFPShQLJiopnGzPy-R16H6Y45P2eKKgFlFvq646yMaQUsX1xw0BvM9S7DPVThhn_9HqDF_h_YuUjvV2YsA</recordid><startdate>20231127</startdate><enddate>20231127</enddate><creator>Jason, Alden S</creator><creator>Sundaram, Gidean A</creator><creator>J, Preethi</creator><creator>Kumar, Santhosh P</creator><creator>Krishnan, Murugesan</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20231127</creationdate><title>Comparison of the Efficacy of Midazolam and Dexmedetomidine As Sedative Agents in Third Molar Surgery</title><author>Jason, Alden S ; Sundaram, Gidean A ; J, Preethi ; Kumar, Santhosh P ; Krishnan, Murugesan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c300t-6ee0c829b599512f6bba9c046d907e480ce0583b7685cf8e123232bdb1a6105d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Anesthesia</topic><topic>Anesthesiology</topic><topic>Anxiety</topic><topic>Blood pressure</topic><topic>Heart rate</topic><topic>Independent sample</topic><topic>Pain Management</topic><topic>Patients</topic><topic>Sample size</topic><topic>Statistical analysis</topic><topic>Surgeons</topic><topic>Surgery</topic><topic>Teeth</topic><topic>Therapeutics</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jason, Alden S</creatorcontrib><creatorcontrib>Sundaram, Gidean A</creatorcontrib><creatorcontrib>J, Preethi</creatorcontrib><creatorcontrib>Kumar, Santhosh P</creatorcontrib><creatorcontrib>Krishnan, Murugesan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jason, Alden S</au><au>Sundaram, Gidean A</au><au>J, Preethi</au><au>Kumar, Santhosh P</au><au>Krishnan, Murugesan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the Efficacy of Midazolam and Dexmedetomidine As Sedative Agents in Third Molar Surgery</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2023-11-27</date><risdate>2023</risdate><volume>15</volume><issue>11</issue><spage>e49477</spage><epage>e49477</epage><pages>e49477-e49477</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Introduction Minor dental and oral surgical procedures have been made comfortable with the rise in the use of daycare sedatives. Of these sedatives, midazolam is deemed a common sedative used for minor oral surgical procedures. Newer and safer sedatives such as dexmedetomidine have certain properties that may prove more efficient in oral surgical procedures. Third molar surgery is one of the most common minor oral surgical procedures performed in dentistry. Thus, this study aims to compare the efficacy of midazolam and dexmedetomidine as sedative agents in third molar surgery. Materials and methods Sixty young adult patients free from other comorbidities were included in the study with ages ranging between 18 and 50 years. The samples were matched for the difficulty of impacted teeth and randomly distributed among the groups. Groups were administered the respective sedative drugs midazolam and dexmedetomidine and their effects were observed through the Observer's Assessment of Alertness/Sedation scale. The intraoperative vitals and sedation effects were checked every 15 minutes. Statistical analysis was done using IBM SPSS Statistics for Windows, Version 22 (Released 2013; IBM Corp., Armonk, New York, United States). Independent samples t-test and analysis of variance were the statistical tests employed to analyze the obtained data with p<0.05 considered as statistically significant. Results The depth of sedation has been both subjectively and objectively assessed and had no significant difference among the groups. The intra-operative heart rate assessment proved a more efficient reduction of pulse rate in the dexmedetomidine group as compared with the midazolam group. However, it was not statistically significant (p=0.121). The mean diastolic blood pressure showed a statistically significant difference between the groups with dexmedetomidine having lower blood diastolic pressure compared to midazolam (p=0.004). Quick arousal was witnessed in the dexmedetomidine group. Conclusion It can be concluded from the study that both dexmedetomidine and midazolam were equally effective as sedative agents for third molar surgery. However, the nature of cardio-protection, anti-sialagogue, and analgesic properties of dexmedetomidine can prove helpful, especially in minor oral surgical procedures like third molar surgery and it is recommended.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>38156170</pmid><doi>10.7759/cureus.49477</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Anesthesia Anesthesiology Anxiety Blood pressure Heart rate Independent sample Pain Management Patients Sample size Statistical analysis Surgeons Surgery Teeth Therapeutics Variance analysis |
| title | Comparison of the Efficacy of Midazolam and Dexmedetomidine As Sedative Agents in Third Molar Surgery |
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