Effect of Nephropathy Prescription I on the Expression of Angptl3 and Podocyte-Associated Protein in Mice with Adriamycin-Induced Nephropathy
Objective. This study aimed to investigate the effects of Nephropathy Prescription I on the expression of angptl3, nephrin, and podocin, in addition to its protective effects on podocytes in mice with adriamycin-induced nephropathy. Methods. BALB/c mice were randomly divided into the control (C), ad...
Gespeichert in:
| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2022, Vol.2022, p.9921679-13 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 13 |
|---|---|
| container_issue | |
| container_start_page | 9921679 |
| container_title | Evidence-based complementary and alternative medicine |
| container_volume | 2022 |
| creator | Zhang, Feifei Liu, Junchao Yu, Jian Sun, Wen Wang, Yonghong Fan, Teng Sun, Yanyan Han, Xinghui |
| description | Objective. This study aimed to investigate the effects of Nephropathy Prescription I on the expression of angptl3, nephrin, and podocin, in addition to its protective effects on podocytes in mice with adriamycin-induced nephropathy. Methods. BALB/c mice were randomly divided into the control (C), adriamycin (Model or M), adriamycin + Nephropathy Prescription I (M + Z), adriamycin + prednisone acetate (M + S), and adriamycin + Nephropathy Prescription I + prednisone acetate groups (M + Z + S). All mice except those in the C group in the experimental groups were treated with a single tail vein injection of adriamycin. The urine albumin-creatinine ratio was measured before model establishment and on the 7th day, 14th day, 21st day, and 28th day of doxorubicin injection. All the mice were sacrificed on the 29th day. Blood samples were collected to observe biochemical indicators in the serum. The morphological structure and podocyte ultrastructure in the kidney were observed using light and electron microscopy, respectively. The expression of angptl3, nephrin, and podocin at the mRNA and protein levels was detected by real-time PCR and western blotting, respectively. Results. Following modeling with adriamycin, albuminuria was observed in urine samples in the first week, and the urinary protein/creatinine ratio increased maximally in the fourth week in the M group (P |
| doi_str_mv | 10.1155/2022/9921679 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10751164</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2914317244</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2949-d8de7cc9fa162c45c6d98fbb7916f9f0504e6e9f019bc80b6e4c68a755f3581d3</originalsourceid><addsrcrecordid>eNp9kV9rFDEUxYMotl1981kCvgg6NslkJpMnWcqqC1X7oOBbyORPJ2U2GZOMdT9Ev7NZd12qD0JILic_zr2XA8AzjN5g3DTnBBFyzjnBLeMPwClmFFeUdN3DY82-nYCzlG4QIpwx9hic1B2mHHf4FNytrDUqw2DhJzMNMUwyD1t4FU1S0U3ZBQ_XsFx5MHD1cyp62mmFX_rrKY81lF7Dq6CD2mZTLVMKyslsihZDNs7Dcj46ZeCtywNc6ujkZqucr9Zez6pw9_o-AY-sHJN5engX4Ou71ZeLD9Xl5_fri-VlpQinvNKdNkwpbiVuiaKNajXvbN8zjlvLLWoQNa0pBea96lDfGqraTrKmsXXTYV0vwNu97zT3G6OV8TnKUUzRbWTciiCd-PvHu0Fchx8CI9Zg3NLi8PLgEMP32aQsNi4pM47SmzAnQThqGSOU1gV98Q96E-boy36FwrTGv7EFeL2nVAwpRWOP02AkdkGLXdDiEHTBn9_f4Aj_SbYAr_bA4LyWt-7_dr8AbLuyjA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2914317244</pqid></control><display><type>article</type><title>Effect of Nephropathy Prescription I on the Expression of Angptl3 and Podocyte-Associated Protein in Mice with Adriamycin-Induced Nephropathy</title><source>PubMed Central Open Access</source><source>Wiley-Blackwell Open Access Titles</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Zhang, Feifei ; Liu, Junchao ; Yu, Jian ; Sun, Wen ; Wang, Yonghong ; Fan, Teng ; Sun, Yanyan ; Han, Xinghui</creator><contributor>Chen, Jianping ; Jianping Chen</contributor><creatorcontrib>Zhang, Feifei ; Liu, Junchao ; Yu, Jian ; Sun, Wen ; Wang, Yonghong ; Fan, Teng ; Sun, Yanyan ; Han, Xinghui ; Chen, Jianping ; Jianping Chen</creatorcontrib><description><![CDATA[Objective. This study aimed to investigate the effects of Nephropathy Prescription I on the expression of angptl3, nephrin, and podocin, in addition to its protective effects on podocytes in mice with adriamycin-induced nephropathy. Methods. BALB/c mice were randomly divided into the control (C), adriamycin (Model or M), adriamycin + Nephropathy Prescription I (M + Z), adriamycin + prednisone acetate (M + S), and adriamycin + Nephropathy Prescription I + prednisone acetate groups (M + Z + S). All mice except those in the C group in the experimental groups were treated with a single tail vein injection of adriamycin. The urine albumin-creatinine ratio was measured before model establishment and on the 7th day, 14th day, 21st day, and 28th day of doxorubicin injection. All the mice were sacrificed on the 29th day. Blood samples were collected to observe biochemical indicators in the serum. The morphological structure and podocyte ultrastructure in the kidney were observed using light and electron microscopy, respectively. The expression of angptl3, nephrin, and podocin at the mRNA and protein levels was detected by real-time PCR and western blotting, respectively. Results. Following modeling with adriamycin, albuminuria was observed in urine samples in the first week, and the urinary protein/creatinine ratio increased maximally in the fourth week in the M group (P<0.05). In contrast, the urinary protein/creatinine ratio significantly decreased (P<0.05) in the third week in the (M + Z) group compared to that in the M group. Similarly, this ratio decreased in the (M + S) and (M + Z + S) groups compared to that in the M group throughout the experiment. Compared with the C group, serum albumin content and the expression of nephrin and podocin decreased (P<0.05), whereas blood lipid level and the expression of angptl3 increased (P<0.05) in the M group. Glomerular foot process fusion was observed in this group using electron microscopy. In all the intervention groups, serum albumin content and the expression of nephrin and podocin increased (P<0.05), whereas blood lipid level and the expression of angptl3 decreased (P<0.05), with alleviated glomerular foot process injury observed particularly in the (M + Z + S) group. Conclusion. The Nephropathy Prescription I can alleviate albuminuria, increase serum albumin levels, lower blood lipid levels, and reduce the fusion of foot processes of podocytes in mice with adriamycin-induced nephropathy. The protective effects of the Nephropathy Prescription I may function by reducing Angptl3 expression and increasing nephrin and podocin expression.]]></description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2022/9921679</identifier><identifier>PMID: 38149181</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Acetic acid ; Albumin ; Biochemistry ; Bioengineering ; Blood levels ; Chinese medicine ; Creatinine ; Doxorubicin ; Edema ; Electron microscopy ; Endocrine therapy ; Feet ; Hair loss ; Kidney diseases ; Kidneys ; Laboratory animals ; Microscopy ; mRNA ; Nephropathy ; Prednisone ; Proteins ; Statistical analysis ; Ultrastructure ; Urine ; Variance analysis ; Western blotting</subject><ispartof>Evidence-based complementary and alternative medicine, 2022, Vol.2022, p.9921679-13</ispartof><rights>Copyright © 2022 Feifei Zhang et al.</rights><rights>Copyright © 2022 Feifei Zhang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Feifei Zhang et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2949-d8de7cc9fa162c45c6d98fbb7916f9f0504e6e9f019bc80b6e4c68a755f3581d3</citedby><cites>FETCH-LOGICAL-c2949-d8de7cc9fa162c45c6d98fbb7916f9f0504e6e9f019bc80b6e4c68a755f3581d3</cites><orcidid>0000-0002-1077-0397</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10751164/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10751164/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38149181$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chen, Jianping</contributor><contributor>Jianping Chen</contributor><creatorcontrib>Zhang, Feifei</creatorcontrib><creatorcontrib>Liu, Junchao</creatorcontrib><creatorcontrib>Yu, Jian</creatorcontrib><creatorcontrib>Sun, Wen</creatorcontrib><creatorcontrib>Wang, Yonghong</creatorcontrib><creatorcontrib>Fan, Teng</creatorcontrib><creatorcontrib>Sun, Yanyan</creatorcontrib><creatorcontrib>Han, Xinghui</creatorcontrib><title>Effect of Nephropathy Prescription I on the Expression of Angptl3 and Podocyte-Associated Protein in Mice with Adriamycin-Induced Nephropathy</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description><![CDATA[Objective. This study aimed to investigate the effects of Nephropathy Prescription I on the expression of angptl3, nephrin, and podocin, in addition to its protective effects on podocytes in mice with adriamycin-induced nephropathy. Methods. BALB/c mice were randomly divided into the control (C), adriamycin (Model or M), adriamycin + Nephropathy Prescription I (M + Z), adriamycin + prednisone acetate (M + S), and adriamycin + Nephropathy Prescription I + prednisone acetate groups (M + Z + S). All mice except those in the C group in the experimental groups were treated with a single tail vein injection of adriamycin. The urine albumin-creatinine ratio was measured before model establishment and on the 7th day, 14th day, 21st day, and 28th day of doxorubicin injection. All the mice were sacrificed on the 29th day. Blood samples were collected to observe biochemical indicators in the serum. The morphological structure and podocyte ultrastructure in the kidney were observed using light and electron microscopy, respectively. The expression of angptl3, nephrin, and podocin at the mRNA and protein levels was detected by real-time PCR and western blotting, respectively. Results. Following modeling with adriamycin, albuminuria was observed in urine samples in the first week, and the urinary protein/creatinine ratio increased maximally in the fourth week in the M group (P<0.05). In contrast, the urinary protein/creatinine ratio significantly decreased (P<0.05) in the third week in the (M + Z) group compared to that in the M group. Similarly, this ratio decreased in the (M + S) and (M + Z + S) groups compared to that in the M group throughout the experiment. Compared with the C group, serum albumin content and the expression of nephrin and podocin decreased (P<0.05), whereas blood lipid level and the expression of angptl3 increased (P<0.05) in the M group. Glomerular foot process fusion was observed in this group using electron microscopy. In all the intervention groups, serum albumin content and the expression of nephrin and podocin increased (P<0.05), whereas blood lipid level and the expression of angptl3 decreased (P<0.05), with alleviated glomerular foot process injury observed particularly in the (M + Z + S) group. Conclusion. The Nephropathy Prescription I can alleviate albuminuria, increase serum albumin levels, lower blood lipid levels, and reduce the fusion of foot processes of podocytes in mice with adriamycin-induced nephropathy. The protective effects of the Nephropathy Prescription I may function by reducing Angptl3 expression and increasing nephrin and podocin expression.]]></description><subject>Acetic acid</subject><subject>Albumin</subject><subject>Biochemistry</subject><subject>Bioengineering</subject><subject>Blood levels</subject><subject>Chinese medicine</subject><subject>Creatinine</subject><subject>Doxorubicin</subject><subject>Edema</subject><subject>Electron microscopy</subject><subject>Endocrine therapy</subject><subject>Feet</subject><subject>Hair loss</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Laboratory animals</subject><subject>Microscopy</subject><subject>mRNA</subject><subject>Nephropathy</subject><subject>Prednisone</subject><subject>Proteins</subject><subject>Statistical analysis</subject><subject>Ultrastructure</subject><subject>Urine</subject><subject>Variance analysis</subject><subject>Western blotting</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kV9rFDEUxYMotl1981kCvgg6NslkJpMnWcqqC1X7oOBbyORPJ2U2GZOMdT9Ev7NZd12qD0JILic_zr2XA8AzjN5g3DTnBBFyzjnBLeMPwClmFFeUdN3DY82-nYCzlG4QIpwx9hic1B2mHHf4FNytrDUqw2DhJzMNMUwyD1t4FU1S0U3ZBQ_XsFx5MHD1cyp62mmFX_rrKY81lF7Dq6CD2mZTLVMKyslsihZDNs7Dcj46ZeCtywNc6ujkZqucr9Zez6pw9_o-AY-sHJN5engX4Ou71ZeLD9Xl5_fri-VlpQinvNKdNkwpbiVuiaKNajXvbN8zjlvLLWoQNa0pBea96lDfGqraTrKmsXXTYV0vwNu97zT3G6OV8TnKUUzRbWTciiCd-PvHu0Fchx8CI9Zg3NLi8PLgEMP32aQsNi4pM47SmzAnQThqGSOU1gV98Q96E-boy36FwrTGv7EFeL2nVAwpRWOP02AkdkGLXdDiEHTBn9_f4Aj_SbYAr_bA4LyWt-7_dr8AbLuyjA</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Zhang, Feifei</creator><creator>Liu, Junchao</creator><creator>Yu, Jian</creator><creator>Sun, Wen</creator><creator>Wang, Yonghong</creator><creator>Fan, Teng</creator><creator>Sun, Yanyan</creator><creator>Han, Xinghui</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1077-0397</orcidid></search><sort><creationdate>2022</creationdate><title>Effect of Nephropathy Prescription I on the Expression of Angptl3 and Podocyte-Associated Protein in Mice with Adriamycin-Induced Nephropathy</title><author>Zhang, Feifei ; Liu, Junchao ; Yu, Jian ; Sun, Wen ; Wang, Yonghong ; Fan, Teng ; Sun, Yanyan ; Han, Xinghui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2949-d8de7cc9fa162c45c6d98fbb7916f9f0504e6e9f019bc80b6e4c68a755f3581d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acetic acid</topic><topic>Albumin</topic><topic>Biochemistry</topic><topic>Bioengineering</topic><topic>Blood levels</topic><topic>Chinese medicine</topic><topic>Creatinine</topic><topic>Doxorubicin</topic><topic>Edema</topic><topic>Electron microscopy</topic><topic>Endocrine therapy</topic><topic>Feet</topic><topic>Hair loss</topic><topic>Kidney diseases</topic><topic>Kidneys</topic><topic>Laboratory animals</topic><topic>Microscopy</topic><topic>mRNA</topic><topic>Nephropathy</topic><topic>Prednisone</topic><topic>Proteins</topic><topic>Statistical analysis</topic><topic>Ultrastructure</topic><topic>Urine</topic><topic>Variance analysis</topic><topic>Western blotting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Feifei</creatorcontrib><creatorcontrib>Liu, Junchao</creatorcontrib><creatorcontrib>Yu, Jian</creatorcontrib><creatorcontrib>Sun, Wen</creatorcontrib><creatorcontrib>Wang, Yonghong</creatorcontrib><creatorcontrib>Fan, Teng</creatorcontrib><creatorcontrib>Sun, Yanyan</creatorcontrib><creatorcontrib>Han, Xinghui</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Feifei</au><au>Liu, Junchao</au><au>Yu, Jian</au><au>Sun, Wen</au><au>Wang, Yonghong</au><au>Fan, Teng</au><au>Sun, Yanyan</au><au>Han, Xinghui</au><au>Chen, Jianping</au><au>Jianping Chen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Nephropathy Prescription I on the Expression of Angptl3 and Podocyte-Associated Protein in Mice with Adriamycin-Induced Nephropathy</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2022</date><risdate>2022</risdate><volume>2022</volume><spage>9921679</spage><epage>13</epage><pages>9921679-13</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract><![CDATA[Objective. This study aimed to investigate the effects of Nephropathy Prescription I on the expression of angptl3, nephrin, and podocin, in addition to its protective effects on podocytes in mice with adriamycin-induced nephropathy. Methods. BALB/c mice were randomly divided into the control (C), adriamycin (Model or M), adriamycin + Nephropathy Prescription I (M + Z), adriamycin + prednisone acetate (M + S), and adriamycin + Nephropathy Prescription I + prednisone acetate groups (M + Z + S). All mice except those in the C group in the experimental groups were treated with a single tail vein injection of adriamycin. The urine albumin-creatinine ratio was measured before model establishment and on the 7th day, 14th day, 21st day, and 28th day of doxorubicin injection. All the mice were sacrificed on the 29th day. Blood samples were collected to observe biochemical indicators in the serum. The morphological structure and podocyte ultrastructure in the kidney were observed using light and electron microscopy, respectively. The expression of angptl3, nephrin, and podocin at the mRNA and protein levels was detected by real-time PCR and western blotting, respectively. Results. Following modeling with adriamycin, albuminuria was observed in urine samples in the first week, and the urinary protein/creatinine ratio increased maximally in the fourth week in the M group (P<0.05). In contrast, the urinary protein/creatinine ratio significantly decreased (P<0.05) in the third week in the (M + Z) group compared to that in the M group. Similarly, this ratio decreased in the (M + S) and (M + Z + S) groups compared to that in the M group throughout the experiment. Compared with the C group, serum albumin content and the expression of nephrin and podocin decreased (P<0.05), whereas blood lipid level and the expression of angptl3 increased (P<0.05) in the M group. Glomerular foot process fusion was observed in this group using electron microscopy. In all the intervention groups, serum albumin content and the expression of nephrin and podocin increased (P<0.05), whereas blood lipid level and the expression of angptl3 decreased (P<0.05), with alleviated glomerular foot process injury observed particularly in the (M + Z + S) group. Conclusion. The Nephropathy Prescription I can alleviate albuminuria, increase serum albumin levels, lower blood lipid levels, and reduce the fusion of foot processes of podocytes in mice with adriamycin-induced nephropathy. The protective effects of the Nephropathy Prescription I may function by reducing Angptl3 expression and increasing nephrin and podocin expression.]]></abstract><cop>United States</cop><pub>Hindawi</pub><pmid>38149181</pmid><doi>10.1155/2022/9921679</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-1077-0397</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1741-427X |
| ispartof | Evidence-based complementary and alternative medicine, 2022, Vol.2022, p.9921679-13 |
| issn | 1741-427X 1741-4288 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10751164 |
| source | PubMed Central Open Access; Wiley-Blackwell Open Access Titles; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acetic acid Albumin Biochemistry Bioengineering Blood levels Chinese medicine Creatinine Doxorubicin Edema Electron microscopy Endocrine therapy Feet Hair loss Kidney diseases Kidneys Laboratory animals Microscopy mRNA Nephropathy Prednisone Proteins Statistical analysis Ultrastructure Urine Variance analysis Western blotting |
| title | Effect of Nephropathy Prescription I on the Expression of Angptl3 and Podocyte-Associated Protein in Mice with Adriamycin-Induced Nephropathy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T13%3A11%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Nephropathy%20Prescription%20I%20on%20the%20Expression%20of%20Angptl3%20and%20Podocyte-Associated%20Protein%20in%20Mice%20with%20Adriamycin-Induced%20Nephropathy&rft.jtitle=Evidence-based%20complementary%20and%20alternative%20medicine&rft.au=Zhang,%20Feifei&rft.date=2022&rft.volume=2022&rft.spage=9921679&rft.epage=13&rft.pages=9921679-13&rft.issn=1741-427X&rft.eissn=1741-4288&rft_id=info:doi/10.1155/2022/9921679&rft_dat=%3Cproquest_pubme%3E2914317244%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2914317244&rft_id=info:pmid/38149181&rfr_iscdi=true |