Improvement of patient care using cancer genomic profiling: SCRUM-/CIRCULATE-Japan experience
We launched SCRUM-Japan platform for the cancer genome profiling (CGP) test screening followed by the enrollment to genomically-matched clinical trials in 2015. More than 30,000 tissue-based and 10,000 liquid-based CGP tests have already been performed for enrolling to a total of 127 industry-/inves...
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| Veröffentlicht in: | Proceedings of the Japan Academy Series B, 2023/10/11, Vol.99(8), pp.241-253 |
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| creator | OHTSU, Atsushi GOTO, Koichi YOSHINO, Takayuki |
| description | We launched SCRUM-Japan platform for the cancer genome profiling (CGP) test screening followed by the enrollment to genomically-matched clinical trials in 2015. More than 30,000 tissue-based and 10,000 liquid-based CGP tests have already been performed for enrolling to a total of 127 industry-/investigator-initiated registration trials, which resulted in regulatory approvals of 12 new agents with 14 indications in Japan. Using the clinical-genomic database, a new driver gene was recently discovered with dramatic response by genomically-matched agent. Our comparative study with tissue-based CGPs revealed more usefulness of liquid biopsy in terms of less invasive manner, shorter turn-round time, and higher enrollment rate for matched treatments than tissue-based in gastrointestinal cancers. For detecting minimal/molecular residual disease (MRD) after surgery, post-surgical monitoring with tumor-informed liquid biopsy assay in association with two randomized control trials have also started in 2020 (CIRCULATE-Japan). The observational cohort study showed obvious efficacy of the MRD monitoring for predicting recurrence, leading to change clinical practice in patient selection who should receive adjuvant therapy in the near future. |
| doi_str_mv | 10.2183/pjab.99.015 |
| format | Article |
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More than 30,000 tissue-based and 10,000 liquid-based CGP tests have already been performed for enrolling to a total of 127 industry-/investigator-initiated registration trials, which resulted in regulatory approvals of 12 new agents with 14 indications in Japan. Using the clinical-genomic database, a new driver gene was recently discovered with dramatic response by genomically-matched agent. Our comparative study with tissue-based CGPs revealed more usefulness of liquid biopsy in terms of less invasive manner, shorter turn-round time, and higher enrollment rate for matched treatments than tissue-based in gastrointestinal cancers. For detecting minimal/molecular residual disease (MRD) after surgery, post-surgical monitoring with tumor-informed liquid biopsy assay in association with two randomized control trials have also started in 2020 (CIRCULATE-Japan). The observational cohort study showed obvious efficacy of the MRD monitoring for predicting recurrence, leading to change clinical practice in patient selection who should receive adjuvant therapy in the near future.</description><identifier>ISSN: 0386-2208</identifier><identifier>ISSN: 0021-4280</identifier><identifier>EISSN: 1349-2896</identifier><identifier>DOI: 10.2183/pjab.99.015</identifier><identifier>PMID: 37558430</identifier><language>eng</language><publisher>Japan: The Japan Academy</publisher><subject>Adjuvant treatment ; Antimitotic agents ; Antineoplastic agents ; Biopsy ; Cancer ; cancer genome medicine ; Cancer patients ; Cancer therapies ; Care and treatment ; Clinical trials ; Collaboration ; Comparative analysis ; Comparative studies ; comprehensive cancer genome profiling ; Diagnosis ; Genes ; Genetic aspects ; Genomes ; Genomics ; Humans ; Japan ; Kinases ; liquid biopsy ; Lung cancer ; Monitoring ; Mutation ; Neoplasms - diagnosis ; Neoplasms - genetics ; Neoplasms - therapy ; Oncology ; Patient Care ; Patients ; Phosphorylation ; Plasma ; precision medicine ; Regulatory approval ; Respiratory agents ; Review ; Tumors</subject><ispartof>Proceedings of the Japan Academy, Series B, 2023/10/11, Vol.99(8), pp.241-253</ispartof><rights>2023 The Author(s).</rights><rights>COPYRIGHT 2023 The Japan Academy</rights><rights>Copyright The Japan Academy Oct 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c690t-abedc3e1b48aaec52cdcc8c2f60098f2670fa8bdaabe6e60acfa8c2428ae2d4e3</citedby><cites>FETCH-LOGICAL-c690t-abedc3e1b48aaec52cdcc8c2f60098f2670fa8bdaabe6e60acfa8c2428ae2d4e3</cites><orcidid>0000-0002-3023-2510 ; 0000-0003-1329-0628 ; 0000-0002-0489-4756</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10749397/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10749397/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,1884,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37558430$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OHTSU, Atsushi</creatorcontrib><creatorcontrib>GOTO, Koichi</creatorcontrib><creatorcontrib>YOSHINO, Takayuki</creatorcontrib><title>Improvement of patient care using cancer genomic profiling: SCRUM-/CIRCULATE-Japan experience</title><title>Proceedings of the Japan Academy</title><addtitle>Proc. Jpn. Acad., Ser. B</addtitle><description>We launched SCRUM-Japan platform for the cancer genome profiling (CGP) test screening followed by the enrollment to genomically-matched clinical trials in 2015. More than 30,000 tissue-based and 10,000 liquid-based CGP tests have already been performed for enrolling to a total of 127 industry-/investigator-initiated registration trials, which resulted in regulatory approvals of 12 new agents with 14 indications in Japan. Using the clinical-genomic database, a new driver gene was recently discovered with dramatic response by genomically-matched agent. Our comparative study with tissue-based CGPs revealed more usefulness of liquid biopsy in terms of less invasive manner, shorter turn-round time, and higher enrollment rate for matched treatments than tissue-based in gastrointestinal cancers. For detecting minimal/molecular residual disease (MRD) after surgery, post-surgical monitoring with tumor-informed liquid biopsy assay in association with two randomized control trials have also started in 2020 (CIRCULATE-Japan). The observational cohort study showed obvious efficacy of the MRD monitoring for predicting recurrence, leading to change clinical practice in patient selection who should receive adjuvant therapy in the near future.</description><subject>Adjuvant treatment</subject><subject>Antimitotic agents</subject><subject>Antineoplastic agents</subject><subject>Biopsy</subject><subject>Cancer</subject><subject>cancer genome medicine</subject><subject>Cancer patients</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Clinical trials</subject><subject>Collaboration</subject><subject>Comparative analysis</subject><subject>Comparative studies</subject><subject>comprehensive cancer genome profiling</subject><subject>Diagnosis</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Humans</subject><subject>Japan</subject><subject>Kinases</subject><subject>liquid biopsy</subject><subject>Lung cancer</subject><subject>Monitoring</subject><subject>Mutation</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - therapy</subject><subject>Oncology</subject><subject>Patient Care</subject><subject>Patients</subject><subject>Phosphorylation</subject><subject>Plasma</subject><subject>precision medicine</subject><subject>Regulatory approval</subject><subject>Respiratory agents</subject><subject>Review</subject><subject>Tumors</subject><issn>0386-2208</issn><issn>0021-4280</issn><issn>1349-2896</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkt1r1EAQwIMo9qw--S4BXwTJdT_yseuLHKHVkxOh9h5lmdubXHMku3GTFPvfd8K1ZyuysB_sb37LzE4UveVsLriSZ90eNnOt54xnz6IZl6lOhNL582jGpMoTIZg6iV71_Z4xKTLFX0YnssgylUo2i34t2y74G2zRDbGv4g6GetpaCBiPfe12tHUWQ7xD59vaxoRXdUMXn-Kf5eX6e3JWLi_L9WpxdZ58gw5cjH86DGSx-Dp6UUHT45v79TRaX5xflV-T1Y8vy3KxSmyu2ZDABrdWIt-kCgBtJuzWWmVFlTOmVSXyglWgNlsgMMecgaWjFalQgGKbojyNPh-83bhpyUUZBGhMF-oWwq3xUJunN66-Njt_YzgrUi11QYYP94bgf4_YD6ate4tNAw792BuhUkUVSzkn9P0_6N6PwVF-RGmWSsVF9pfaQYOmdpWnh-0kNYuiYFJKxSbX_D8UjS1Srb1DKjU-Dfh4CLDB933A6pgkZ2ZqBzO1g9HaUDsQ_e5xXY7sw_8TcHEA9v0AOzwCEIba0ssPMjVNj8xHwF5DMOjkHZMbyoA</recordid><startdate>20231011</startdate><enddate>20231011</enddate><creator>OHTSU, Atsushi</creator><creator>GOTO, Koichi</creator><creator>YOSHINO, Takayuki</creator><general>The Japan Academy</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BVBZV</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3023-2510</orcidid><orcidid>https://orcid.org/0000-0003-1329-0628</orcidid><orcidid>https://orcid.org/0000-0002-0489-4756</orcidid></search><sort><creationdate>20231011</creationdate><title>Improvement of patient care using cancer genomic profiling: SCRUM-/CIRCULATE-Japan experience</title><author>OHTSU, Atsushi ; GOTO, Koichi ; YOSHINO, Takayuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c690t-abedc3e1b48aaec52cdcc8c2f60098f2670fa8bdaabe6e60acfa8c2428ae2d4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adjuvant treatment</topic><topic>Antimitotic agents</topic><topic>Antineoplastic agents</topic><topic>Biopsy</topic><topic>Cancer</topic><topic>cancer genome medicine</topic><topic>Cancer patients</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Clinical trials</topic><topic>Collaboration</topic><topic>Comparative analysis</topic><topic>Comparative studies</topic><topic>comprehensive cancer genome profiling</topic><topic>Diagnosis</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Humans</topic><topic>Japan</topic><topic>Kinases</topic><topic>liquid biopsy</topic><topic>Lung cancer</topic><topic>Monitoring</topic><topic>Mutation</topic><topic>Neoplasms - diagnosis</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - therapy</topic><topic>Oncology</topic><topic>Patient Care</topic><topic>Patients</topic><topic>Phosphorylation</topic><topic>Plasma</topic><topic>precision medicine</topic><topic>Regulatory approval</topic><topic>Respiratory agents</topic><topic>Review</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OHTSU, Atsushi</creatorcontrib><creatorcontrib>GOTO, Koichi</creatorcontrib><creatorcontrib>YOSHINO, Takayuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>East & South Asia Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the Japan Academy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OHTSU, Atsushi</au><au>GOTO, Koichi</au><au>YOSHINO, Takayuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improvement of patient care using cancer genomic profiling: SCRUM-/CIRCULATE-Japan experience</atitle><jtitle>Proceedings of the Japan Academy</jtitle><addtitle>Proc. 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Our comparative study with tissue-based CGPs revealed more usefulness of liquid biopsy in terms of less invasive manner, shorter turn-round time, and higher enrollment rate for matched treatments than tissue-based in gastrointestinal cancers. For detecting minimal/molecular residual disease (MRD) after surgery, post-surgical monitoring with tumor-informed liquid biopsy assay in association with two randomized control trials have also started in 2020 (CIRCULATE-Japan). 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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Project Euclid Open Access; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adjuvant treatment Antimitotic agents Antineoplastic agents Biopsy Cancer cancer genome medicine Cancer patients Cancer therapies Care and treatment Clinical trials Collaboration Comparative analysis Comparative studies comprehensive cancer genome profiling Diagnosis Genes Genetic aspects Genomes Genomics Humans Japan Kinases liquid biopsy Lung cancer Monitoring Mutation Neoplasms - diagnosis Neoplasms - genetics Neoplasms - therapy Oncology Patient Care Patients Phosphorylation Plasma precision medicine Regulatory approval Respiratory agents Review Tumors |
| title | Improvement of patient care using cancer genomic profiling: SCRUM-/CIRCULATE-Japan experience |
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