Protective effects of epigallocatechin-3-gallate counteracting the chronic hypobaric hypoxia-induced myocardial injury in plain-grown rats at high altitude
Exposure to hypobaric hypoxia (HH) environment causes stress to the body, especially the oxygen-consuming organs. Chronic HH conditions have adverse effects on the myocardium. Thus, we conducted this experiment and aim to evaluate such adverse effects and explore the therapeutic role of epigallocate...
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| Veröffentlicht in: | Cell stress & chaperones 2023-11, Vol.28 (6), p.921-933 |
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| creator | Chen, Haotian Chen, Chen Qin, Yuhui Wang, Lei Zheng, Jie Gao, Fabao |
| description | Exposure to hypobaric hypoxia (HH) environment causes stress to the body, especially the oxygen-consuming organs. Chronic HH conditions have adverse effects on the myocardium. Thus, we conducted this experiment and aim to evaluate such adverse effects and explore the therapeutic role of epigallocatechin-3-gallate (EGCG) in rats’ heart under chronic HH conditions. For that purpose, we transported rats from plain to a real HH environment at high altitude for establishing the HH model. At high altitude, animals were treated with EGCG while the salidroside was used as the positive control. General physiological data were collected, and routine blood test results were analyzed. Cardiac magnetic resonance (CMR) was examined to assess the structural and functional changes of the heart. Serum levels of cardiac enzymes and pro-inflammatory cytokines were examined. Oxidative markers in the left ventricle (LV) were detected. Additionally, ultrastructural and histopathological changes and apoptosis of the LV were assessed. Furthermore, the antioxidant stress-relevant proteins nuclear factor E2-related factor 2 (Nrf2) and the heme oxygenase-1 (HO-1) were detected. The experiment revealed that EGCG treatment decreased HH-induced elevation of cardiac enzymes and relieved mitochondrial damage of the LV. Notably, EGCG treatment significantly alleviated oxidative stress in the LV and inflammatory response in the blood. Western blot confirmed that EGCG significantly upregulated Nrf2 and HO-1. Therefore, EGCG may be considered a promising natural compound for treating the HH-induced myocardial injuries. |
| doi_str_mv | 10.1007/s12192-023-01386-1 |
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Chronic HH conditions have adverse effects on the myocardium. Thus, we conducted this experiment and aim to evaluate such adverse effects and explore the therapeutic role of epigallocatechin-3-gallate (EGCG) in rats’ heart under chronic HH conditions. For that purpose, we transported rats from plain to a real HH environment at high altitude for establishing the HH model. At high altitude, animals were treated with EGCG while the salidroside was used as the positive control. General physiological data were collected, and routine blood test results were analyzed. Cardiac magnetic resonance (CMR) was examined to assess the structural and functional changes of the heart. Serum levels of cardiac enzymes and pro-inflammatory cytokines were examined. Oxidative markers in the left ventricle (LV) were detected. Additionally, ultrastructural and histopathological changes and apoptosis of the LV were assessed. Furthermore, the antioxidant stress-relevant proteins nuclear factor E2-related factor 2 (Nrf2) and the heme oxygenase-1 (HO-1) were detected. The experiment revealed that EGCG treatment decreased HH-induced elevation of cardiac enzymes and relieved mitochondrial damage of the LV. Notably, EGCG treatment significantly alleviated oxidative stress in the LV and inflammatory response in the blood. Western blot confirmed that EGCG significantly upregulated Nrf2 and HO-1. Therefore, EGCG may be considered a promising natural compound for treating the HH-induced myocardial injuries.</description><identifier>ISSN: 1355-8145</identifier><identifier>EISSN: 1466-1268</identifier><identifier>DOI: 10.1007/s12192-023-01386-1</identifier><identifier>PMID: 37875765</identifier><language>eng</language><publisher>Dordrecht: Springer Science + Business Media</publisher><subject>Altitude ; Apoptosis ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Blood ; Cancer Research ; Cell Biology ; Enzymes ; Epigallocatechin gallate ; Heart ; Heme oxygenase (decyclizing) ; High altitude ; High-altitude environments ; Hypoxia ; Immunology ; Inflammation ; Inflammatory response ; Magnetic resonance ; Myocardium ; Neurosciences ; Original ; ORIGINAL ARTICLE ; Oxidative stress ; Serum levels ; Side effects ; Structure-function relationships ; Ventricle</subject><ispartof>Cell stress & chaperones, 2023-11, Vol.28 (6), p.921-933</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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Chronic HH conditions have adverse effects on the myocardium. Thus, we conducted this experiment and aim to evaluate such adverse effects and explore the therapeutic role of epigallocatechin-3-gallate (EGCG) in rats’ heart under chronic HH conditions. For that purpose, we transported rats from plain to a real HH environment at high altitude for establishing the HH model. At high altitude, animals were treated with EGCG while the salidroside was used as the positive control. General physiological data were collected, and routine blood test results were analyzed. Cardiac magnetic resonance (CMR) was examined to assess the structural and functional changes of the heart. Serum levels of cardiac enzymes and pro-inflammatory cytokines were examined. Oxidative markers in the left ventricle (LV) were detected. Additionally, ultrastructural and histopathological changes and apoptosis of the LV were assessed. Furthermore, the antioxidant stress-relevant proteins nuclear factor E2-related factor 2 (Nrf2) and the heme oxygenase-1 (HO-1) were detected. The experiment revealed that EGCG treatment decreased HH-induced elevation of cardiac enzymes and relieved mitochondrial damage of the LV. Notably, EGCG treatment significantly alleviated oxidative stress in the LV and inflammatory response in the blood. Western blot confirmed that EGCG significantly upregulated Nrf2 and HO-1. Therefore, EGCG may be considered a promising natural compound for treating the HH-induced myocardial injuries.</description><subject>Altitude</subject><subject>Apoptosis</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood</subject><subject>Cancer Research</subject><subject>Cell Biology</subject><subject>Enzymes</subject><subject>Epigallocatechin gallate</subject><subject>Heart</subject><subject>Heme oxygenase (decyclizing)</subject><subject>High altitude</subject><subject>High-altitude environments</subject><subject>Hypoxia</subject><subject>Immunology</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Magnetic resonance</subject><subject>Myocardium</subject><subject>Neurosciences</subject><subject>Original</subject><subject>ORIGINAL ARTICLE</subject><subject>Oxidative stress</subject><subject>Serum levels</subject><subject>Side effects</subject><subject>Structure-function relationships</subject><subject>Ventricle</subject><issn>1355-8145</issn><issn>1466-1268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9UcuO1DAQjBCIXRZ-AAlkaS9cAm7biZMTWq2Wh7QSHOBsOY6TeJSxB9tZmG_hZ-khw_A4cOpud1W1u6songJ9CZTKVwkYtKykjJcUeFOXcK84B1FjwurmPua8qsoGRHVWPEppQ5EkJTwszrhsZCXr6rz4_jGGbE12d5bYYcAskTAQu3OjnudgNDYn50teHmqsiAmLzzZq5PiR5Alfphi8M2Ta70Kn4zH75nTpfL8Y25PtHpVi7_RMnN8scY-B7GaNwmMMXz2JGufqTCY3TkTP2eWlt4-LB4Oek31yjBfF5zc3n67flbcf3r6_vrotjWhlLttWCC00AGOSGm2Hru56aeueCmuZhkZILnpmOwNV3-DlBloB5a0A0Q1D2_GL4vWqu1u6re2N9TnqWe2i2-q4V0E79XfHu0mN4U4BlXjtqkGFF0eFGL4sNmW1dclYPJi3YUmKNQ1IYJQfoJf_QDdhiR73U6yloq1lLStEsRVlYkgp2uH0G6DqYL5azVdovvppvgIkPf9zjxPll9sI4CsgYcuPNv6e_V_ZZytrk3KIJ1WBom0Lkv8AVczIbA</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Chen, Haotian</creator><creator>Chen, Chen</creator><creator>Qin, Yuhui</creator><creator>Wang, Lei</creator><creator>Zheng, Jie</creator><creator>Gao, Fabao</creator><general>Springer Science + Business Media</general><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2257-3275</orcidid></search><sort><creationdate>20231101</creationdate><title>Protective effects of epigallocatechin-3-gallate counteracting the chronic hypobaric hypoxia-induced myocardial injury in plain-grown rats at high altitude</title><author>Chen, Haotian ; Chen, Chen ; Qin, Yuhui ; Wang, Lei ; Zheng, Jie ; Gao, Fabao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-9944a4a112270caefb6bd7e6d04ee2a184734d2ebc15d8100f051039414bff9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Altitude</topic><topic>Apoptosis</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood</topic><topic>Cancer Research</topic><topic>Cell Biology</topic><topic>Enzymes</topic><topic>Epigallocatechin gallate</topic><topic>Heart</topic><topic>Heme oxygenase (decyclizing)</topic><topic>High altitude</topic><topic>High-altitude environments</topic><topic>Hypoxia</topic><topic>Immunology</topic><topic>Inflammation</topic><topic>Inflammatory response</topic><topic>Magnetic resonance</topic><topic>Myocardium</topic><topic>Neurosciences</topic><topic>Original</topic><topic>ORIGINAL ARTICLE</topic><topic>Oxidative stress</topic><topic>Serum levels</topic><topic>Side effects</topic><topic>Structure-function relationships</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Haotian</creatorcontrib><creatorcontrib>Chen, Chen</creatorcontrib><creatorcontrib>Qin, Yuhui</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Zheng, Jie</creatorcontrib><creatorcontrib>Gao, Fabao</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell stress & chaperones</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Haotian</au><au>Chen, Chen</au><au>Qin, Yuhui</au><au>Wang, Lei</au><au>Zheng, Jie</au><au>Gao, Fabao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effects of epigallocatechin-3-gallate counteracting the chronic hypobaric hypoxia-induced myocardial injury in plain-grown rats at high altitude</atitle><jtitle>Cell stress & chaperones</jtitle><stitle>Cell Stress and Chaperones</stitle><addtitle>Cell Stress Chaperones</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>28</volume><issue>6</issue><spage>921</spage><epage>933</epage><pages>921-933</pages><issn>1355-8145</issn><eissn>1466-1268</eissn><abstract>Exposure to hypobaric hypoxia (HH) environment causes stress to the body, especially the oxygen-consuming organs. Chronic HH conditions have adverse effects on the myocardium. Thus, we conducted this experiment and aim to evaluate such adverse effects and explore the therapeutic role of epigallocatechin-3-gallate (EGCG) in rats’ heart under chronic HH conditions. For that purpose, we transported rats from plain to a real HH environment at high altitude for establishing the HH model. At high altitude, animals were treated with EGCG while the salidroside was used as the positive control. General physiological data were collected, and routine blood test results were analyzed. Cardiac magnetic resonance (CMR) was examined to assess the structural and functional changes of the heart. Serum levels of cardiac enzymes and pro-inflammatory cytokines were examined. Oxidative markers in the left ventricle (LV) were detected. Additionally, ultrastructural and histopathological changes and apoptosis of the LV were assessed. Furthermore, the antioxidant stress-relevant proteins nuclear factor E2-related factor 2 (Nrf2) and the heme oxygenase-1 (HO-1) were detected. The experiment revealed that EGCG treatment decreased HH-induced elevation of cardiac enzymes and relieved mitochondrial damage of the LV. Notably, EGCG treatment significantly alleviated oxidative stress in the LV and inflammatory response in the blood. Western blot confirmed that EGCG significantly upregulated Nrf2 and HO-1. Therefore, EGCG may be considered a promising natural compound for treating the HH-induced myocardial injuries.</abstract><cop>Dordrecht</cop><pub>Springer Science + Business Media</pub><pmid>37875765</pmid><doi>10.1007/s12192-023-01386-1</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-2257-3275</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Altitude Apoptosis Biochemistry Biomedical and Life Sciences Biomedicine Blood Cancer Research Cell Biology Enzymes Epigallocatechin gallate Heart Heme oxygenase (decyclizing) High altitude High-altitude environments Hypoxia Immunology Inflammation Inflammatory response Magnetic resonance Myocardium Neurosciences Original ORIGINAL ARTICLE Oxidative stress Serum levels Side effects Structure-function relationships Ventricle |
| title | Protective effects of epigallocatechin-3-gallate counteracting the chronic hypobaric hypoxia-induced myocardial injury in plain-grown rats at high altitude |
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