Antigen exposure reshapes chromatin architecture in central memory CD8 + T cells and imprints enhanced recall capacity

CD62L central memory CD8 T (T ) cells provide enhanced protection than naive cells; however, the underlying mechanism, especially the contribution of higher-order genomic organization, remains unclear. Systematic Hi-C analyses reveal that antigen-experienced CD8 T cells undergo extensive rewiring of...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-12, Vol.120 (51), p.e2313476120
Hauptverfasser:	Zhu, Shaoqi, Liu, Jia, Patel, Vanita, Zhao, Xiuyi, Peng, Weiqun, Xue, Hai-Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Antigens Binding Sites Biological Sciences CCCTC-Binding Factor - genetics CCCTC-Binding Factor - metabolism CD8 antigen CD8-Positive T-Lymphocytes Chromatin Chromatin - genetics Cytotoxicity Enhancers Genes Genomic imprinting Genomics Hubs Immunological memory L-selectin Lymphocytes Lymphocytes T Memory cells Recall Transcriptomics
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