LFA-1 in T cell priming, differentiation, and effector functions

The integrin LFA-1 is crucial for T cell entry into mammalian lymph nodes and tissues, and for promoting interactions with antigen-presenting cells (APCs). However, it is increasingly evident that LFA-1 has additional key roles beyond the mere support of adhesion between T cells, the endothelium, an...

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Veröffentlicht in:	Trends in immunology 2021-08, Vol.42 (8), p.706-722
Hauptverfasser:	Gérard, Audrey, Cope, Andrew P., Kemper, Claudia, Alon, Ronen, Köchl, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Adhesives Animals Antigen-Presenting Cells Antigens Cell Differentiation Cell division Cell interactions Chemokines complement Cytoskeleton Endothelium Immunological memory Immunological synapses Immunology Intercellular Adhesion Molecule-1 Intracellular signalling Kinases LFA-1 LFA-1 antigen Ligands Lymph nodes Lymphatic system Lymphocyte Function-Associated Antigen-1 Lymphocytes Lymphocytes T mechanosensing mechanotransduction Memory cells Microscopy Motility Peptides Priming PTPN22 Synapses T cell receptors Th1 Cells WNK1
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