Phosphonoacetate Modifications Enhance the Stability and Editing Yields of Guide RNAs for Cas9 Editors

CRISPR gene editing and control systems continue to emerge and inspire novel research and clinical applications. Advances in CRISPR performance such as optimizing the duration of activity in cells, tissues, and organisms, as well as limiting off-target activities, have been extremely important for e...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemistry (Easton) 2023-12, Vol.62 (24), p.3512-3520
Hauptverfasser:	Ryan, Daniel E., Diamant-Levi, Tamar, Steinfeld, Israel, Taussig, David, Visal-Shah, Savita, Thakker, Suhani, Lunstad, Benjamin D., Kaiser, Robert J., McCaffrey, Ryan, Ortiz, Michael, Townsend, Justin, Welch, William R. W., Singh, Mandeep, Curry, Bo, Dellinger, Douglas J., Bruhn, Laurakay
Format:	Artikel
Sprache:	eng
Schlagworte:	CRISPR-Cas Systems Gene Editing - methods Humans Phosphonoacetic Acid RNA, Guide, CRISPR-Cas Systems RNA, Messenger
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!