csi-miR-96-5p delivered by Clonorchis sinensis extracellular vesicles promotes intrahepatic cholangiocarcinoma proliferation and migration via the ferroptosis-related PTEN/SLC7A11/GPX4 axis

Clonorchis sinensis (CS) is classified as a group 1 carcinogen and can cause intrahepatic cholangiocarcinoma (ICC). CS extracellular vesicles (CsEVs) play important roles in mediating communication between parasitic helminths and humans. Ferroptosis is a novel cell death mechanism that is mainly ind...

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Veröffentlicht in:	Parasites & vectors 2023-12, Vol.16 (1), p.465
Hauptverfasser:	Wen, Li-Jia, Yin, Ji-Gang, Wang, Yong-Xin, Liu, Kai, Zhao, Ji-Xue
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport System y Analysis Animals Bile Duct Neoplasms Bile ducts Bile Ducts, Intrahepatic Biomarkers Cancer Carcinogens Cell death Cell interactions Cell lines Cell migration Cell organelles Cell Proliferation Cells Cholangiocarcinoma Cholangiocarcinoma - genetics Chromosome 5 Clonorchis sinensis Communication Complications and side effects CRISPR Disease Electron microscopy Extracellular Vesicles Ferroptosis Ferroptosis - genetics Fluke infections Gene editing Gene expression Genetic aspects Health aspects Humans Infections Lipid peroxidation Lipids Liver Malondialdehyde Membranes MicroRNA MicroRNAs MicroRNAs - genetics Microscopy Neoplasms Nucleotide sequence Oncology, Experimental Penicillin Peroxidation Physiological aspects Polymerase chain reaction Proliferation PTEN Phosphohydrolase - genetics PTEN protein Reactive oxygen species Reagents Survival Transmission electron microscopy Tumors Ultracentrifugation Vesicles Western blotting Worms Xenotransplantation
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