An injectable and adaptable hydrogen sulfide delivery system for modulating neuroregenerative microenvironment
Peripheral nerve regeneration is a complex physiological process. Single-function nerve scaffolds often struggle to quickly adapt to the imbalanced regenerative microenvironment, leading to slow nerve regeneration and limited functional recovery. In this study, we demonstrate a "pleiotropic gas...
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| Veröffentlicht in: | Science advances 2023-12, Vol.9 (51), p.eadi1078-eadi1078 |
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| creator | Dong, Xianzhen Zhang, Hao Duan, Ping Liu, Kun Yu, Yifeng Wei, Wenying Wang, Weixing Liu, Yuhang Cheng, Qiang Liang, Xinyue Huo, Yuanfang Yan, Lesan Yu, Aixi Dai, Honglian |
| description | Peripheral nerve regeneration is a complex physiological process. Single-function nerve scaffolds often struggle to quickly adapt to the imbalanced regenerative microenvironment, leading to slow nerve regeneration and limited functional recovery. In this study, we demonstrate a "pleiotropic gas transmitter" strategy based on endogenous reactive oxygen species (ROS), which trigger the on-demand H
S release at the defect area for transected peripheral nerve injury (PNI) repair through concurrent neuroregeneration and neuroprotection processing. This H
S delivery system consists of an H
S donor (peroxyTCM) encapsulated in a ROS-responsive polymer (mPEG-PMet) and loaded into a temperature-sensitive poly (amino acid) hydrogel (mPEG-PA-PP). This multi-effect combination strategy greatly promotes the regeneration of PNI, attributed to the physiological effects of H
S. These effects include the inhibition of inflammation and oxidative stress, protection of nerve cells, promotion of angiogenesis, and the restoration of normal mitochondrial function. The adaptive release of pleiotropic messengers to modulate the tissue regeneration microenvironment offers promising peripheral nerve repair and tissue engineering opportunities. |
| doi_str_mv | 10.1126/sciadv.adi1078 |
| format | Article |
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S release at the defect area for transected peripheral nerve injury (PNI) repair through concurrent neuroregeneration and neuroprotection processing. This H
S delivery system consists of an H
S donor (peroxyTCM) encapsulated in a ROS-responsive polymer (mPEG-PMet) and loaded into a temperature-sensitive poly (amino acid) hydrogel (mPEG-PA-PP). This multi-effect combination strategy greatly promotes the regeneration of PNI, attributed to the physiological effects of H
S. These effects include the inhibition of inflammation and oxidative stress, protection of nerve cells, promotion of angiogenesis, and the restoration of normal mitochondrial function. The adaptive release of pleiotropic messengers to modulate the tissue regeneration microenvironment offers promising peripheral nerve repair and tissue engineering opportunities.</description><identifier>ISSN: 2375-2548</identifier><identifier>EISSN: 2375-2548</identifier><identifier>DOI: 10.1126/sciadv.adi1078</identifier><identifier>PMID: 38117891</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Biomedicine and Life Sciences ; Humans ; Hydrogen Sulfide - pharmacology ; Nerve Regeneration ; Neuroscience ; Peripheral Nerve Injuries - drug therapy ; Polyethylene Glycols ; Reactive Oxygen Species ; SciAdv r-articles</subject><ispartof>Science advances, 2023-12, Vol.9 (51), p.eadi1078-eadi1078</ispartof><rights>Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). 2023 The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-e35921bad4bebb4b101073be8f2a61c63f54a7712e83f39c3317e69a36676e913</citedby><cites>FETCH-LOGICAL-c391t-e35921bad4bebb4b101073be8f2a61c63f54a7712e83f39c3317e69a36676e913</cites><orcidid>0000-0003-3616-9628 ; 0000-0002-6434-2865 ; 0000-0002-1272-0895 ; 0000-0003-3842-6843 ; 0000-0003-2472-1534 ; 0000-0001-7833-9651 ; 0000-0002-5723-6140 ; 0000-0003-2921-905X ; 0009-0003-2354-3569</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732521/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732521/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38117891$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dong, Xianzhen</creatorcontrib><creatorcontrib>Zhang, Hao</creatorcontrib><creatorcontrib>Duan, Ping</creatorcontrib><creatorcontrib>Liu, Kun</creatorcontrib><creatorcontrib>Yu, Yifeng</creatorcontrib><creatorcontrib>Wei, Wenying</creatorcontrib><creatorcontrib>Wang, Weixing</creatorcontrib><creatorcontrib>Liu, Yuhang</creatorcontrib><creatorcontrib>Cheng, Qiang</creatorcontrib><creatorcontrib>Liang, Xinyue</creatorcontrib><creatorcontrib>Huo, Yuanfang</creatorcontrib><creatorcontrib>Yan, Lesan</creatorcontrib><creatorcontrib>Yu, Aixi</creatorcontrib><creatorcontrib>Dai, Honglian</creatorcontrib><title>An injectable and adaptable hydrogen sulfide delivery system for modulating neuroregenerative microenvironment</title><title>Science advances</title><addtitle>Sci Adv</addtitle><description>Peripheral nerve regeneration is a complex physiological process. Single-function nerve scaffolds often struggle to quickly adapt to the imbalanced regenerative microenvironment, leading to slow nerve regeneration and limited functional recovery. In this study, we demonstrate a "pleiotropic gas transmitter" strategy based on endogenous reactive oxygen species (ROS), which trigger the on-demand H
S release at the defect area for transected peripheral nerve injury (PNI) repair through concurrent neuroregeneration and neuroprotection processing. This H
S delivery system consists of an H
S donor (peroxyTCM) encapsulated in a ROS-responsive polymer (mPEG-PMet) and loaded into a temperature-sensitive poly (amino acid) hydrogel (mPEG-PA-PP). This multi-effect combination strategy greatly promotes the regeneration of PNI, attributed to the physiological effects of H
S. These effects include the inhibition of inflammation and oxidative stress, protection of nerve cells, promotion of angiogenesis, and the restoration of normal mitochondrial function. The adaptive release of pleiotropic messengers to modulate the tissue regeneration microenvironment offers promising peripheral nerve repair and tissue engineering opportunities.</description><subject>Biomedicine and Life Sciences</subject><subject>Humans</subject><subject>Hydrogen Sulfide - pharmacology</subject><subject>Nerve Regeneration</subject><subject>Neuroscience</subject><subject>Peripheral Nerve Injuries - drug therapy</subject><subject>Polyethylene Glycols</subject><subject>Reactive Oxygen Species</subject><subject>SciAdv r-articles</subject><issn>2375-2548</issn><issn>2375-2548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUT1rwzAQFaWlCWnWjkVjl6Q-yZbtqYTQLwh0aWchW-dEwZZSyTbk39chaUin-3r33h2PkHuI5gBMPIXSKN3PlTYQpdkVGTOeJjOWxNn1RT4i0xC2URRBLEQC-S0Z8QwgzXIYE7uw1Ngtlq0qaqTKaqq02h2rzV57t0ZLQ1dXRiPVWJse_Z6GfWixoZXztHG6q1Vr7Jpa7LzzOGygHzo90saU3qHtjXe2QdvekZtK1QGnpzgh368vX8v32erz7WO5WM1KnkM7Q57kDAql4wKLIi4gGh7kBWYVUwJKwaskVmkKDDNe8bzkHFIUueJCpAJz4BPyfOTddUWDuhykvarlzptG-b10ysj_E2s2cu16edBhCTswPJ4YvPvpMLSyMaHEulYWXRcky6M4GbCCD9D5ETr8GoLH6qwDkTwYJY9GyZNRw8LD5XVn-J8t_BfEr5SM</recordid><startdate>20231222</startdate><enddate>20231222</enddate><creator>Dong, Xianzhen</creator><creator>Zhang, Hao</creator><creator>Duan, Ping</creator><creator>Liu, Kun</creator><creator>Yu, Yifeng</creator><creator>Wei, Wenying</creator><creator>Wang, Weixing</creator><creator>Liu, Yuhang</creator><creator>Cheng, Qiang</creator><creator>Liang, Xinyue</creator><creator>Huo, Yuanfang</creator><creator>Yan, Lesan</creator><creator>Yu, Aixi</creator><creator>Dai, Honglian</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3616-9628</orcidid><orcidid>https://orcid.org/0000-0002-6434-2865</orcidid><orcidid>https://orcid.org/0000-0002-1272-0895</orcidid><orcidid>https://orcid.org/0000-0003-3842-6843</orcidid><orcidid>https://orcid.org/0000-0003-2472-1534</orcidid><orcidid>https://orcid.org/0000-0001-7833-9651</orcidid><orcidid>https://orcid.org/0000-0002-5723-6140</orcidid><orcidid>https://orcid.org/0000-0003-2921-905X</orcidid><orcidid>https://orcid.org/0009-0003-2354-3569</orcidid></search><sort><creationdate>20231222</creationdate><title>An injectable and adaptable hydrogen sulfide delivery system for modulating neuroregenerative microenvironment</title><author>Dong, Xianzhen ; Zhang, Hao ; Duan, Ping ; Liu, Kun ; Yu, Yifeng ; Wei, Wenying ; Wang, Weixing ; Liu, Yuhang ; Cheng, Qiang ; Liang, Xinyue ; Huo, Yuanfang ; Yan, Lesan ; Yu, Aixi ; Dai, Honglian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-e35921bad4bebb4b101073be8f2a61c63f54a7712e83f39c3317e69a36676e913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biomedicine and Life Sciences</topic><topic>Humans</topic><topic>Hydrogen Sulfide - pharmacology</topic><topic>Nerve Regeneration</topic><topic>Neuroscience</topic><topic>Peripheral Nerve Injuries - drug therapy</topic><topic>Polyethylene Glycols</topic><topic>Reactive Oxygen Species</topic><topic>SciAdv r-articles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dong, Xianzhen</creatorcontrib><creatorcontrib>Zhang, Hao</creatorcontrib><creatorcontrib>Duan, Ping</creatorcontrib><creatorcontrib>Liu, Kun</creatorcontrib><creatorcontrib>Yu, Yifeng</creatorcontrib><creatorcontrib>Wei, Wenying</creatorcontrib><creatorcontrib>Wang, Weixing</creatorcontrib><creatorcontrib>Liu, Yuhang</creatorcontrib><creatorcontrib>Cheng, Qiang</creatorcontrib><creatorcontrib>Liang, Xinyue</creatorcontrib><creatorcontrib>Huo, Yuanfang</creatorcontrib><creatorcontrib>Yan, Lesan</creatorcontrib><creatorcontrib>Yu, Aixi</creatorcontrib><creatorcontrib>Dai, Honglian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dong, Xianzhen</au><au>Zhang, Hao</au><au>Duan, Ping</au><au>Liu, Kun</au><au>Yu, Yifeng</au><au>Wei, Wenying</au><au>Wang, Weixing</au><au>Liu, Yuhang</au><au>Cheng, Qiang</au><au>Liang, Xinyue</au><au>Huo, Yuanfang</au><au>Yan, Lesan</au><au>Yu, Aixi</au><au>Dai, Honglian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An injectable and adaptable hydrogen sulfide delivery system for modulating neuroregenerative microenvironment</atitle><jtitle>Science advances</jtitle><addtitle>Sci Adv</addtitle><date>2023-12-22</date><risdate>2023</risdate><volume>9</volume><issue>51</issue><spage>eadi1078</spage><epage>eadi1078</epage><pages>eadi1078-eadi1078</pages><issn>2375-2548</issn><eissn>2375-2548</eissn><abstract>Peripheral nerve regeneration is a complex physiological process. Single-function nerve scaffolds often struggle to quickly adapt to the imbalanced regenerative microenvironment, leading to slow nerve regeneration and limited functional recovery. In this study, we demonstrate a "pleiotropic gas transmitter" strategy based on endogenous reactive oxygen species (ROS), which trigger the on-demand H
S release at the defect area for transected peripheral nerve injury (PNI) repair through concurrent neuroregeneration and neuroprotection processing. This H
S delivery system consists of an H
S donor (peroxyTCM) encapsulated in a ROS-responsive polymer (mPEG-PMet) and loaded into a temperature-sensitive poly (amino acid) hydrogel (mPEG-PA-PP). This multi-effect combination strategy greatly promotes the regeneration of PNI, attributed to the physiological effects of H
S. These effects include the inhibition of inflammation and oxidative stress, protection of nerve cells, promotion of angiogenesis, and the restoration of normal mitochondrial function. The adaptive release of pleiotropic messengers to modulate the tissue regeneration microenvironment offers promising peripheral nerve repair and tissue engineering opportunities.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>38117891</pmid><doi>10.1126/sciadv.adi1078</doi><orcidid>https://orcid.org/0000-0003-3616-9628</orcidid><orcidid>https://orcid.org/0000-0002-6434-2865</orcidid><orcidid>https://orcid.org/0000-0002-1272-0895</orcidid><orcidid>https://orcid.org/0000-0003-3842-6843</orcidid><orcidid>https://orcid.org/0000-0003-2472-1534</orcidid><orcidid>https://orcid.org/0000-0001-7833-9651</orcidid><orcidid>https://orcid.org/0000-0002-5723-6140</orcidid><orcidid>https://orcid.org/0000-0003-2921-905X</orcidid><orcidid>https://orcid.org/0009-0003-2354-3569</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Science advances, 2023-12, Vol.9 (51), p.eadi1078-eadi1078 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Biomedicine and Life Sciences Humans Hydrogen Sulfide - pharmacology Nerve Regeneration Neuroscience Peripheral Nerve Injuries - drug therapy Polyethylene Glycols Reactive Oxygen Species SciAdv r-articles |
| title | An injectable and adaptable hydrogen sulfide delivery system for modulating neuroregenerative microenvironment |
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