Palmitate-Induced Inflammation and Myotube Atrophy in C2C12 Cells Are Prevented by the Whey Bioactive Peptide, Glycomacropeptide

Metabolic diseases are often associated with muscle atrophy and heightened inflammation. The whey bioactive compound, glycomacropeptide (GMP), has been shown to exhibit anti-inflammatory properties and therefore may have potential therapeutic efficacy in conditions of skeletal muscle inflammation an...

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Veröffentlicht in:	The Journal of nutrition 2023-10, Vol.153 (10), p.2915-2928
Hauptverfasser:	de Hart, Naomi MMP, Petrocelli, Jonathan J., Nicholson, Rebekah J., Yee, Elena M., Ferrara, Patrick J., Bastian, Eric D., Ward, Loren S., Petersen, Brent L., Summers, Scott A., Drummond, Micah J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Anti-inflammatory agents Atrophy Bioactive compounds Biological activity C2C12 Cellular stress response Cytokines Diglycerides Extracellular signal-regulated kinase Gene expression Glycomacropeptide Humans Inflammation Inflammation - metabolism Insulin Insulin resistance Metabolic disorders muscle atrophy Muscle Fibers, Skeletal - metabolism Muscle function Muscle, Skeletal Muscles Muscular Atrophy - chemically induced Muscular Atrophy - prevention & control Myoblasts Myostatin Myotubes Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions Palmitates - metabolism Palmitates - toxicity Palmitic acid Pathogenesis Peptide Fragments Phosphorylation Protein biosynthesis protein breakdown Protein synthesis Proteins Proteolysis Skeletal muscle TLR4 protein Toll-like receptors Ubiquitin Whey Whey - metabolism whey protein
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