Circulating metabolites modulated by diet are associated with depression

Metabolome reflects the interplay of genome and exposome at molecular level and thus can provide deep insights into the pathogenesis of a complex disease like major depression. To identify metabolites associated with depression we performed a metabolome-wide association analysis in 13,596 participan...

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Veröffentlicht in:	Molecular psychiatry 2023-09, Vol.28 (9), p.3874-3887
Hauptverfasser:	van der Spek, Ashley, Stewart, Isobel D., Kühnel, Brigitte, Pietzner, Maik, Alshehri, Tahani, Gauß, Friederike, Hysi, Pirro G., MahmoudianDehkordi, Siamak, Heinken, Almut, Luik, Annemarie I., Ladwig, Karl-Heinz, Kastenmüller, Gabi, Menni, Cristina, Hertel, Johannes, Ikram, M. Arfan, de Mutsert, Renée, Suhre, Karsten, Gieger, Christian, Strauch, Konstantin, Völzke, Henry, Meitinger, Thomas, Mangino, Massimo, Flaquer, Antonia, Waldenberger, Melanie, Peters, Annette, Thiele, Ines, Kaddurah-Daouk, Rima, Dunlop, Boadie W., Rosendaal, Frits R., Wareham, Nicholas J., Spector, Tim D., Kunze, Sonja, Grabe, Hans Jörgen, Mook-Kanamori, Dennis O., Langenberg, Claudia, van Duijn, Cornelia M., Amin, Najaf
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337 692/699/476/1414 Acids Association analysis Behavioral Sciences Biological Psychology Carbohydrate metabolism Depression - metabolism Diet Genomes High-performance liquid chromatography Hippurates Humans Lecithin Lysophosphatidic acid Mannitol Mass spectroscopy Medicine Medicine & Public Health Mental depression Metabolism Metabolites Metabolome - genetics Metabolomics - methods Neurosciences Pharmacotherapy Psychiatry Sorbitol Tandem Mass Spectrometry Vitamin A Vitamin A - metabolism
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