Anxiolytic effect of antidiabetic metformin is mediated by AMPK activation in mPFC inhibitory neurons

Diabetic patients receiving the antidiabetic drug metformin have been observed to exhibit a lower prevalence of anxiety disorders, yet the precise mechanism behind this phenomenon is unclear. In our study, we found that anxiety induces a region-specific reduction in AMPK activity in the medial prefr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular psychiatry 2023-09, Vol.28 (9), p.3955-3965
Hauptverfasser:	Zhang, Yong-mei, Zong, Hai-chao, Qi, Ying-bei, Chang, Liu-liu, Gao, Ya-nan, Zhou, Ting, Yin, Tao, Liu, Meng, Pan, Kai-jun, Chen, Wen-gang, Guo, Hao-ran, Guo, Fei, Peng, Yan-min, Wang, Min, Feng, Lin-yin, Zang, Yi, Li, Yang, Li, Jia
Format:	Artikel
Sprache:	eng
Schlagworte:	38/32 42/70 631/378 64/60 692/699/476/1414 9/74 AMP-Activated Protein Kinases - pharmacology Animals Anti-Anxiety Agents - pharmacology Antidiabetics Anxiety Anxiety disorders Behavioral Sciences Biological Psychology Brain slice preparation Diabetes mellitus GABAergic Neurons Humans Hypoglycemic Agents - pharmacology Medicine Medicine & Public Health Metformin Metformin - pharmacology Mice Neurogenesis Neurosciences Pharmacotherapy Prefrontal Cortex Psychiatry Pyramidal cells Social behavior Social interactions Transgenic mice γ-Aminobutyric acid
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!