The H2Bub1-deposition complex is required for human and mouse cardiogenesis

De novo variants affecting monoubiquitylation of histone H2B (H2Bub1) are enriched in human congenital heart disease. H2Bub1 is required in stem cell differentiation, cilia function, post-natal cardiomyocyte maturation and transcriptional elongation. However, how H2Bub1 affects cardiogenesis is unkn...

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Veröffentlicht in:	Development (Cambridge) 2023-12, Vol.150 (23)
Hauptverfasser:	Barish, Syndi, Berg, Kathryn, Drozd, Jeffrey, Berglund-Brown, Isabella, Khizir, Labeeqa, Wasson, Lauren K, Seidman, Christine E, Seidman, Jonathan G, Chen, Sidi, Brueckner, Martina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Heart Heart Defects, Congenital Histones - metabolism Human Development Humans Mice Ubiquitin-Conjugating Enzymes - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination
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