Discovery of Novel NLRP3 Inflammasome Inhibitors Composed of an Oxazole Scaffold Bearing an Acylsulfamide

The NLRP3 inflammasome plays an important role in the defense mechanism of the innate immune system and has recently attracted much attention as a drug target for various inflammatory disorders. Among the strategies for generating the novel chemotype in current drug discovery, scaffold hopping and b...

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Veröffentlicht in:	ACS medicinal chemistry letters 2023-12, Vol.14 (12), p.1833-1838
Hauptverfasser:	Ohba, Yusuke, Adachi, Kaoru, Furukawa, Takayuki, Nishimaru, Tatsuya, Sakurai, Kentaro, Masuo, Ritsuki, Inami, Tasuku, Orita, Takuya, Akai, Shota, Adachi, Tsuyoshi, Usui, Kenji, Hamada, Yuji, Mori, Mutsuki, Kurimoto, Takafumi, Wakashima, Takeshi, Akiyama, Yoshiyuki, Miyazaki, Susumu, Noji, Satoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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