Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device

A major challenge to advance lipid nanoparticles (LNPs) for RNA therapeutics is the development of formulations that can be produced reliably across the various scales of drug development. Microfluidics can generate LNPs with precisely defined properties, but have been limited by challenges in scali...

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Veröffentlicht in:	Nano letters 2021-07, Vol.21 (13), p.5671-5680
Hauptverfasser:	Shepherd, Sarah J, Warzecha, Claude C, Yadavali, Sagar, El-Mayta, Rakan, Alameh, Mohamad-Gabriel, Wang, Lili, Weissman, Drew, Wilson, James M, Issadore, David, Mitchell, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Lab-On-A-Chip Devices Lipids Mice Nanoparticles RNA, Messenger RNA, Small Interfering - genetics
Online-Zugang:	Volltext
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