Unlocking the anti‐diabetic potential of Gymnema sylvestre, Trigonella foenum‐graecum, and their combination thereof: An in‐vivo evaluation
The current study aimed to explore the anti‐diabetic effect of aqueous extracts of Gymnema sylvestre, Trigonella foenum‐graecum and mixture of both the plants in alloxan‐induced diabetic rabbits. A total of 30 rabbits were grouped into six equal groups as: normal control, diabetic control, diabetic...
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| creator | Kashif, Muhammad Nasir, Amar Gulzaman Rafique, Muhammad Kamran Abbas, Mazhar ur Rehman, Aziz Riaz, Muhammad Rasool, Ghulam Mtewa, Andrew G. |
| description | The current study aimed to explore the anti‐diabetic effect of aqueous extracts of Gymnema sylvestre, Trigonella foenum‐graecum and mixture of both the plants in alloxan‐induced diabetic rabbits. A total of 30 rabbits were grouped into six equal groups as: normal control, diabetic control, diabetic treated with 300 mg/kg body weight (bw) G. sylvestre, diabetic treated with 300 mg/kg bw T. foenum‐graecum, diabetic treated with 300 mg/kg bw mixture of both the plants and diabetic treated with 500 mg/kg bw metformin for 4 weeks. Diabetes was induced to all the study group animals except normal control by intravenous administration of alloxan monohydrate (80 mg/kg bw). Blood glucose was measured by glucometer and other biochemical parameters were determined through various kit methods. Serum insulin was measured through ELISA kit method. Results showed that both the plants and metformin significantly (p |
| doi_str_mv | 10.1002/fsn3.3685 |
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Methanolic extract of Gymnema sylvestre and Trigonella foenum‐graecum strongly possessed the anti‐diabetic property. These effects are comparable with the standard drug metformin. The studied plants extract treatment maintained the body weight, decrease the urea and creatinine level, and increases the activity of liver enzymes in diabetic rabbits.</description><identifier>ISSN: 2048-7177</identifier><identifier>EISSN: 2048-7177</identifier><identifier>DOI: 10.1002/fsn3.3685</identifier><identifier>PMID: 38107140</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Alloxan ; Alternative medicine ; Animal sciences ; Animals ; Antidiabetics ; anti‐diabetic effect ; Biological products ; Blood ; Blood glucose ; Blood levels ; Blood sugar ; Body weight ; Cell size ; Creatinine ; Diabetes ; Diabetes mellitus ; Diabetes therapy ; Drug dosages ; Enzymes ; Flavonoids ; Glucose ; glucose level ; Gymnema sylvestre ; Herbal medicine ; Hyperglycemia ; Insulin ; Insulin resistance ; Insulin secretion ; Intravenous administration ; Laboratory animals ; Medicinal plants ; Metformin ; Mixtures ; Original ; Parameters ; Phytochemicals ; Plant extracts ; Pyrimidines ; Rabbits ; Seeds ; serum biochemistry ; Trigonella foenum-graecum ; Type 2 diabetes ; Urea ; Vincristine</subject><ispartof>Food Science & Nutrition, 2023-12, Vol.11 (12), p.7664-7672</ispartof><rights>2023 The Authors. published by Wiley Periodicals LLC.</rights><rights>2023 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.</rights><rights>COPYRIGHT 2023 John Wiley & Sons, Inc.</rights><rights>2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4715-a0575e29742f49360edc5c4dca37bfd1cc3b4b4190dcc42b06ad3f362afcaac33</cites><orcidid>0000-0002-5524-7735 ; 0000-0003-2618-7451</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10724615/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10724615/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38107140$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kashif, Muhammad</creatorcontrib><creatorcontrib>Nasir, Amar</creatorcontrib><creatorcontrib>Gulzaman</creatorcontrib><creatorcontrib>Rafique, Muhammad Kamran</creatorcontrib><creatorcontrib>Abbas, Mazhar</creatorcontrib><creatorcontrib>ur Rehman, Aziz</creatorcontrib><creatorcontrib>Riaz, Muhammad</creatorcontrib><creatorcontrib>Rasool, Ghulam</creatorcontrib><creatorcontrib>Mtewa, Andrew G.</creatorcontrib><title>Unlocking the anti‐diabetic potential of Gymnema sylvestre, Trigonella foenum‐graecum, and their combination thereof: An in‐vivo evaluation</title><title>Food Science & Nutrition</title><addtitle>Food Sci Nutr</addtitle><description>The current study aimed to explore the anti‐diabetic effect of aqueous extracts of Gymnema sylvestre, Trigonella foenum‐graecum and mixture of both the plants in alloxan‐induced diabetic rabbits. A total of 30 rabbits were grouped into six equal groups as: normal control, diabetic control, diabetic treated with 300 mg/kg body weight (bw) G. sylvestre, diabetic treated with 300 mg/kg bw T. foenum‐graecum, diabetic treated with 300 mg/kg bw mixture of both the plants and diabetic treated with 500 mg/kg bw metformin for 4 weeks. Diabetes was induced to all the study group animals except normal control by intravenous administration of alloxan monohydrate (80 mg/kg bw). Blood glucose was measured by glucometer and other biochemical parameters were determined through various kit methods. Serum insulin was measured through ELISA kit method. Results showed that both the plants and metformin significantly (p < .05) decreased the fasting blood glucose. Hypoglycemic activity of aqueous extract of G. sylvestre and metformin was found slightly higher than aqueous extract of T. foenum‐graecum and the mixture of both the plants. However, a significant (p < .05) rise in insulin secretion was observed in studied plants extract treated rabbits. Serum urea, creatinine, and liver enzymes were found reduced significantly (p < .05) in treated rabbits whereas packed cell volume was also returned to normal in treated animals as compared to control group. The study concluded that G. sylvestre and T. foenum‐graecum extracts have comparable effects with metformin in normalizing the blood glucose level and have more pronounced effect than metformin in restoring the serum biochemical parameters to normal levels. Hence, these plants may be the good alternative medicine in managing the diabetes mellitus.
Methanolic extract of Gymnema sylvestre and Trigonella foenum‐graecum strongly possessed the anti‐diabetic property. These effects are comparable with the standard drug metformin. The studied plants extract treatment maintained the body weight, decrease the urea and creatinine level, and increases the activity of liver enzymes in diabetic rabbits.</description><subject>Alloxan</subject><subject>Alternative medicine</subject><subject>Animal sciences</subject><subject>Animals</subject><subject>Antidiabetics</subject><subject>anti‐diabetic effect</subject><subject>Biological products</subject><subject>Blood</subject><subject>Blood glucose</subject><subject>Blood levels</subject><subject>Blood sugar</subject><subject>Body weight</subject><subject>Cell size</subject><subject>Creatinine</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes therapy</subject><subject>Drug dosages</subject><subject>Enzymes</subject><subject>Flavonoids</subject><subject>Glucose</subject><subject>glucose level</subject><subject>Gymnema sylvestre</subject><subject>Herbal medicine</subject><subject>Hyperglycemia</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Insulin secretion</subject><subject>Intravenous administration</subject><subject>Laboratory animals</subject><subject>Medicinal plants</subject><subject>Metformin</subject><subject>Mixtures</subject><subject>Original</subject><subject>Parameters</subject><subject>Phytochemicals</subject><subject>Plant extracts</subject><subject>Pyrimidines</subject><subject>Rabbits</subject><subject>Seeds</subject><subject>serum biochemistry</subject><subject>Trigonella foenum-graecum</subject><subject>Type 2 diabetes</subject><subject>Urea</subject><subject>Vincristine</subject><issn>2048-7177</issn><issn>2048-7177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kk9u1TAQxiMEolXpggsgS2xA6nv1v8QJG_RU0YJUtQvateU4duqS2A87CXo7joA4AWfpUXoSJn2lKkjYC1vj3_eNZzRZ9pLgJcGYHtrk2ZIVZf4k26WYlwtBhHj66L6T7ad0jWFVnBSUPs92WEmwIBzvZj8vfRf0F-dbNFwZpPzgbr__aJyqzeA0WofBQEh1KFh0sum96RVKm24yaYjmAF1E1wZvuk4hG4wfexC3URk99gdg1symLiId-tp5Nbjg50g0wb5DK3_zy3kQTG4KyEyqG--IF9kzq7pk9u_Pvezy-MPF0cfF6fnJp6PV6UJzQfKFwrnIDa0Ep5ZXrMCm0bnmjVZM1LYhWrOa15xUuNGa0xoXqmGWFVRZrZRmbC97v_Vdj3UPYig0qk6uo-tV3MignPz7xbsr2YZJQu8oL0gODm_uHWL4OkJLZO-SnrvhTRiTpBVmjBYVKQF9_Q96Hcboob6ZoqQqOZ0Nl1uqVZ2RztsAiTXsxvROQ6Otg_hKCIFzxkoKgrdbgY4hpWjsw_cJlvN4yHk85DwewL56XO8D-WcYADjcAt8gy-b_TvL48xm7s_wNHjzLdA</recordid><startdate>202312</startdate><enddate>202312</enddate><creator>Kashif, 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the anti‐diabetic potential of Gymnema sylvestre, Trigonella foenum‐graecum, and their combination thereof: An in‐vivo evaluation</title><author>Kashif, Muhammad ; Nasir, Amar ; Gulzaman ; Rafique, Muhammad Kamran ; Abbas, Mazhar ; ur Rehman, Aziz ; Riaz, Muhammad ; Rasool, Ghulam ; Mtewa, Andrew G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4715-a0575e29742f49360edc5c4dca37bfd1cc3b4b4190dcc42b06ad3f362afcaac33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alloxan</topic><topic>Alternative medicine</topic><topic>Animal sciences</topic><topic>Animals</topic><topic>Antidiabetics</topic><topic>anti‐diabetic effect</topic><topic>Biological products</topic><topic>Blood</topic><topic>Blood glucose</topic><topic>Blood levels</topic><topic>Blood sugar</topic><topic>Body weight</topic><topic>Cell size</topic><topic>Creatinine</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes therapy</topic><topic>Drug dosages</topic><topic>Enzymes</topic><topic>Flavonoids</topic><topic>Glucose</topic><topic>glucose level</topic><topic>Gymnema sylvestre</topic><topic>Herbal medicine</topic><topic>Hyperglycemia</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Insulin secretion</topic><topic>Intravenous administration</topic><topic>Laboratory animals</topic><topic>Medicinal plants</topic><topic>Metformin</topic><topic>Mixtures</topic><topic>Original</topic><topic>Parameters</topic><topic>Phytochemicals</topic><topic>Plant extracts</topic><topic>Pyrimidines</topic><topic>Rabbits</topic><topic>Seeds</topic><topic>serum biochemistry</topic><topic>Trigonella foenum-graecum</topic><topic>Type 2 diabetes</topic><topic>Urea</topic><topic>Vincristine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kashif, Muhammad</creatorcontrib><creatorcontrib>Nasir, Amar</creatorcontrib><creatorcontrib>Gulzaman</creatorcontrib><creatorcontrib>Rafique, Muhammad Kamran</creatorcontrib><creatorcontrib>Abbas, Mazhar</creatorcontrib><creatorcontrib>ur Rehman, Aziz</creatorcontrib><creatorcontrib>Riaz, Muhammad</creatorcontrib><creatorcontrib>Rasool, Ghulam</creatorcontrib><creatorcontrib>Mtewa, Andrew G.</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium 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Amar</au><au>Gulzaman</au><au>Rafique, Muhammad Kamran</au><au>Abbas, Mazhar</au><au>ur Rehman, Aziz</au><au>Riaz, Muhammad</au><au>Rasool, Ghulam</au><au>Mtewa, Andrew G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unlocking the anti‐diabetic potential of Gymnema sylvestre, Trigonella foenum‐graecum, and their combination thereof: An in‐vivo evaluation</atitle><jtitle>Food Science & Nutrition</jtitle><addtitle>Food Sci Nutr</addtitle><date>2023-12</date><risdate>2023</risdate><volume>11</volume><issue>12</issue><spage>7664</spage><epage>7672</epage><pages>7664-7672</pages><issn>2048-7177</issn><eissn>2048-7177</eissn><abstract>The current study aimed to explore the anti‐diabetic effect of aqueous extracts of Gymnema sylvestre, Trigonella foenum‐graecum and mixture of both the plants in alloxan‐induced diabetic rabbits. A total of 30 rabbits were grouped into six equal groups as: normal control, diabetic control, diabetic treated with 300 mg/kg body weight (bw) G. sylvestre, diabetic treated with 300 mg/kg bw T. foenum‐graecum, diabetic treated with 300 mg/kg bw mixture of both the plants and diabetic treated with 500 mg/kg bw metformin for 4 weeks. Diabetes was induced to all the study group animals except normal control by intravenous administration of alloxan monohydrate (80 mg/kg bw). Blood glucose was measured by glucometer and other biochemical parameters were determined through various kit methods. Serum insulin was measured through ELISA kit method. Results showed that both the plants and metformin significantly (p < .05) decreased the fasting blood glucose. Hypoglycemic activity of aqueous extract of G. sylvestre and metformin was found slightly higher than aqueous extract of T. foenum‐graecum and the mixture of both the plants. However, a significant (p < .05) rise in insulin secretion was observed in studied plants extract treated rabbits. Serum urea, creatinine, and liver enzymes were found reduced significantly (p < .05) in treated rabbits whereas packed cell volume was also returned to normal in treated animals as compared to control group. The study concluded that G. sylvestre and T. foenum‐graecum extracts have comparable effects with metformin in normalizing the blood glucose level and have more pronounced effect than metformin in restoring the serum biochemical parameters to normal levels. Hence, these plants may be the good alternative medicine in managing the diabetes mellitus.
Methanolic extract of Gymnema sylvestre and Trigonella foenum‐graecum strongly possessed the anti‐diabetic property. These effects are comparable with the standard drug metformin. The studied plants extract treatment maintained the body weight, decrease the urea and creatinine level, and increases the activity of liver enzymes in diabetic rabbits.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>38107140</pmid><doi>10.1002/fsn3.3685</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5524-7735</orcidid><orcidid>https://orcid.org/0000-0003-2618-7451</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Food Science & Nutrition, 2023-12, Vol.11 (12), p.7664-7672 |
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| source | Wiley-Blackwell Open Access Titles; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Alloxan Alternative medicine Animal sciences Animals Antidiabetics anti‐diabetic effect Biological products Blood Blood glucose Blood levels Blood sugar Body weight Cell size Creatinine Diabetes Diabetes mellitus Diabetes therapy Drug dosages Enzymes Flavonoids Glucose glucose level Gymnema sylvestre Herbal medicine Hyperglycemia Insulin Insulin resistance Insulin secretion Intravenous administration Laboratory animals Medicinal plants Metformin Mixtures Original Parameters Phytochemicals Plant extracts Pyrimidines Rabbits Seeds serum biochemistry Trigonella foenum-graecum Type 2 diabetes Urea Vincristine |
| title | Unlocking the anti‐diabetic potential of Gymnema sylvestre, Trigonella foenum‐graecum, and their combination thereof: An in‐vivo evaluation |
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