Structural Dynamics of P-Rex1 Complexed with Natural Leads Establishes the Protein as an Attractive Target for Therapeutics to Suppress Cancer Metastasis

Phosphatidylinositol 3,4,5-trisphosphate- (PIP3-) dependent Rac exchanger 1 (P-Rex1) functions as Rho guanine nucleotide exchange factor and is activated by synergistic activity of Gβγ and PIP3 of the heterotrimeric G protein. P-Rex1 activates Rac GTPases for regulating cell invasion and migration a...

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Veröffentlicht in:	BioMed research international 2023, Vol.2023 (1), p.3882081-3882081
Hauptverfasser:	Hameed, Alaa R., Ali, Sama Fakhri, Alsallameh, Sarah M. S., Muhseen, Ziyad Tariq, Almansour, Nahlah Makki, ALSuhaymi, Naif, Alsugoor, Mahdi H., Allemailem, Khaled S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Alanine Binders Binding energy Binding sites Biocompatibility Bonding strength Cancer Cell migration Chemical bonds Comparative analysis Complex formation Distribution functions Energy Enzymes Free energy Gold Guanine nucleotide exchange factor Hydrogen bonding Hydrogen bonds In vivo methods and tests Kinases Libraries Ligands Metastases Metastasis Molecular dynamics Mutagenesis Neutrophils Nucleotides Oncology Phosphatase Phosphatidylinositol Phosphatidylinositol 3,4,5-triphosphate Prostate cancer Proteins Radial distribution Residues Simulation Skin cancer Therapeutic targets Thermodynamics Toxicity
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