Alpha-tocopheryl succinate and doxorubicin-loaded liposomes improve drug uptake and tumor accumulation in a murine breast tumor model

Liposomes composed of a rigid bilayer have high plasma stability; however, they can be challenged in efficacy due to complications in releasing the encapsulated drug as well as being internalized by the tumor cell. On the other hand, fusogenic liposomes may fuse with the plasmatic membrane and relea...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2023-09, Vol.165, p.115034-115034, Article 115034
Hauptverfasser:	Boratto, Fernanda A., Lages, Eduardo B., Loures, Cristina M.C., Sabino, Adriano P., Malachias, Angelo, Townsend, Danyelle M., Branco De Barros, Andre Luis, Miranda Ferreira, Lucas Antonio, Amaral Leite, Elaine
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Tocopherol - pharmacology Alpha-tocopheryl succinate Animals Breast cancer Breast Neoplasms - drug therapy Cell Line, Tumor Doxorubicin Doxorubicin - pharmacology Female Humans Liposomes Mice PH-sensitive liposomes Succinates Tumor accumulation
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