Antiviral treatment in schizophrenia: a randomized pilot PET study on the effects of valaciclovir on neuroinflammation

Patients with schizophrenia experience cognitive impairment, which could be related to neuroinflammation in the hippocampus. The cause for such hippocampal inflammation is still unknown, but it has been suggested that herpes virus infection is involved. This study therefore aimed to determine whethe...

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Veröffentlicht in:	Psychological medicine 2023-11, Vol.53 (15), p.7087-7095
Hauptverfasser:	Jonker, Iris, Doorduin, Janine, Knegtering, Henderikus, van't Hag, Erna, Dierckx, Rudi A., de Vries, Erik F. J., Schoevers, Robert A., Klein, Hans C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala Antiviral agents Antiviral drugs Brain stem Clinical trials Cognitive ability Cognitive functioning Cognitive impairment Drug dosages Encephalitis Frontal lobe Herpes viruses Hippocampus Infections Inflammation Intervention Intravenous therapy Kinases Medical research Mental disorders Nucleus accumbens Occipital lobe Original Original Article Parahippocampal gyrus Parietal lobe Patients Pharmacy Positron emission tomography Psychosis Psychotic symptoms Schizophrenia Statistical significance Temporal lobe Temporal lobes Tomography
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