IL-38 alleviates airway remodeling in chronic asthma via blocking the profibrotic effect of IL-36γ

Airway remodeling is a major feature of asthma. Interleukin (IL)-36γ is significantly upregulated and promotes airway hyper-responsiveness (AHR) in asthma, but its role in airway remodeling is unknown. Here, we aimed to investigate the role of IL-36γ in airway remodeling, and whether IL-38 can allev...

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Veröffentlicht in:	Clinical and experimental immunology 2023-12, Vol.214 (3), p.260-274
Hauptverfasser:	Zhang, Min, Zhou, Jian-Xia, Huang, Chu-Qin, Feng, Kang-Ni, Zou, Xiao-Ling, Cen, Jie-Mei, Meng, Ping, Li, Hong-Tao, Zhang, Tian-Tuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway Remodeling Allergy and Asthma Animals Asthma - metabolism Disease Models, Animal Humans Inflammation - metabolism Interleukins - metabolism Lung - metabolism Mice Mice, Inbred BALB C Pyroglyphidae
Online-Zugang:	Volltext
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