H3K4me3 remodeling induced acquired resistance through O-GlcNAc transferase

Drivers of the drug tolerant proliferative persister (DTPP) state have not been well investigated. Histone H3 lysine-4 trimethylation (H3K4me3), an active histone mark, might enable slow cycling drug tolerant persisters (DTP) to regain proliferative capacity. This study aimed to determine H3K4me3 tr...

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Veröffentlicht in:	Drug resistance updates 2023-11, Vol.71, p.100993-100993, Article 100993
Hauptverfasser:	Ravindran Menon, Dinoop, Hammerlindl, Heinz, Gimenez, Gregory, Hammerlindl, Sabrina, Zuegner, Elmar, Torrano, Joachim, Bordag, Natalie, Emran, Abdullah Al, Giam, Maybelline, Denil, Simon, Pavelka, Norman, Tan, Aik-Choon, Sturm, Richard A., Haass, Nikolas K., Rancati, Giulia, Herlyn, Meenhard, Magnes, Christoph, Eccles, Michael R., Fujita, Mayumi, Schaider, Helmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired drug resistance Adaptive cancer drug resistance AMP-Activated Protein Kinases Cancer persisters Cellular reprogramming Down-Regulation Epigenetics H3K4me3 Histones - genetics Humans Metabolism Mixed Function Oxygenases OGT Proto-Oncogene Proteins TET1
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