Ivabradine preserves dynamic sympathetic control of heart rate despite inducing significant bradycardia in rats

Ivabradine is a selective bradycardic agent that inhibits hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. HCN channels play a key role in mediating the positive chronotropic response to sympathetic nerve stimulation (SNS). We examined whether ivabradine would interfere with dynam...

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Veröffentlicht in:	The journal of physiological sciences 2019-03, Vol.69 (2), p.211-222
Hauptverfasser:	Kawada, Toru, Shimizu, Shuji, Uemura, Kazunori, Hayama, Yohsuke, Yamamoto, Hiromi, Shishido, Toshiaki, Nishikawa, Takuya, Sugimachi, Masaru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure - drug effects Bradycardia Bradycardia - drug therapy Bradycardia - metabolism Cardiac arrhythmia Heart beat Heart rate Heart Rate - drug effects Hyperpolarization Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism Intravenous administration Ion channels (cyclic nucleotide-gated) Ivabradine Ivabradine - pharmacology Male Metoprolol Metoprolol - pharmacology Original Paper Rats Rats, Inbred WKY Rodents Sympathetic Nervous System - drug effects Sympathetic Nervous System - metabolism Sympathetic stimulation Transfer function
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