Subepithelial trypsin induces enteric nerve-mediated anion secretion by activating proteinase-activated receptor 1 in the mouse cecum

Serine proteases are versatile signaling molecules and often exert this function by activating the proteinase-activated receptors (PAR1–PAR4). Our previous study on the mouse cecum has shown that the PAR1-activating peptide (AP) and PAR2-AP both induced electrogenic anion secretion. This secretion m...

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Veröffentlicht in:	The journal of physiological sciences 2012-05, Vol.62 (3), p.211-219
Hauptverfasser:	Ikehara, Osamu, Hayashi, Hisayoshi, Waguri, Toshiharu, Kaji, Izumi, Karaki, Shin-ichiro, Kuwahara, Atsukazu, Suzuki, Yuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Hydroxytryptamine Animal Biochemistry Animal Physiology Animals Anions - metabolism Biomedical and Life Sciences Biomedicine Cecum - drug effects Cecum - metabolism Cell Physiology Diarrhea Eicosanoid Eicosanoids - physiology Enteric Nervous System - drug effects Enteric Nervous System - physiology Human Physiology Indomethacin - pharmacology Inflammation Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Male Masoprocol - pharmacology Mice Neurobiology Neurosciences Oligopeptides - physiology Original Paper Proadifen - pharmacology Protease Inhibitors - pharmacology Receptor, PAR-1 - metabolism Serine protease Serotonin - pharmacology Substance P Trypsin - pharmacology
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