Regulation of gastric motility and blood flow during acute nociceptive stimulation of the paraspinal muscles in urethane-anaesthetised rats
The aim of this study was to examine gastric motility and blood flow during nociceptive hypertonic saline injections (HS) in paraspinal muscles of urethane-anaesthetised rats. Gastric pressure was not affected by HS in intact or vagotomised conditions. After cervical spinalisation, it was decreased...
Gespeichert in:
| Veröffentlicht in: | The journal of physiological sciences 2014-01, Vol.64 (1), p.37-46 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 46 |
|---|---|
| container_issue | 1 |
| container_start_page | 37 |
| container_title | The journal of physiological sciences |
| container_volume | 64 |
| creator | Piché, Mathieu Watanabe, Nobuhiro Hotta, Harumi |
| description | The aim of this study was to examine gastric motility and blood flow during nociceptive hypertonic saline injections (HS) in paraspinal muscles of urethane-anaesthetised rats. Gastric pressure was not affected by HS in intact or vagotomised conditions. After cervical spinalisation, it was decreased by injections at T13 or L6 but not T2. Moreover, HS injections at T13 produced greater gastric pressure decreases compared with L6 and T2 and increased gastric sympathetic nerve activity. Blood pressure and gastric blood flow were decreased by T13 injections in spinal cord intact but not spinalised rats. Besides, isotonic saline injections (non-nociceptive) produced non-significant or marginal effects. These results indicate that gastric motility is decreased by nociceptive input from paraspinal muscles in spinalised rats through activation of the gastric sympathetic nerve. Although gastric blood flow was also decreased by nociceptive stimulation at T13 in spinal cord intact rats, these changes seem to depend on blood pressure. |
| doi_str_mv | 10.1007/s12576-013-0288-1 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10717917</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>24037728</sourcerecordid><originalsourceid>FETCH-LOGICAL-c424t-d0830922ae0579af85b8c48dfec1ed00958388c2afb1d5978ff62b22a0159633</originalsourceid><addsrcrecordid>eNpVkd9qFTEQh4MotlYfwBvJC6xOsn-SvRIpVoWCIL0Ps8nknMhusiTZSp_Bl3bL0UO9moH5_b65-Bh7K-C9AFAfipC9GhoQbQNS60Y8Y5dCa2iGfpDPz3s3XLBXpfwE6IZR6pfsQnbQKiX1Jfv9gw7bjDWkyJPnByw1B8uXVMMc6gPH6Pg0p-S4n9Mv7rYc4oGj3SrxmGywtNZwT7zUsDzh1CPxFTOWNUSc-bIVO1PhIfItUz1ipAYjUtlzNRRyPGMtr9kLj3OhN3_nFbu7-Xx3_bW5_f7l2_Wn28Z2squNA93CKCUS9GpEr_tJ2047T1aQAxh73WptJfpJuH5U2vtBTnseRD8ObXvFPp6w6zYt5CzFmnE2aw4L5geTMJj_LzEczSHdGwFKqFGonSBOBJtTKZn8uSzAPJoxJzNmN2MezRixd949_Xpu_FPR_gFr047Z</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Regulation of gastric motility and blood flow during acute nociceptive stimulation of the paraspinal muscles in urethane-anaesthetised rats</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>SpringerNature Journals</source><source>PubMed Central</source><creator>Piché, Mathieu ; Watanabe, Nobuhiro ; Hotta, Harumi</creator><creatorcontrib>Piché, Mathieu ; Watanabe, Nobuhiro ; Hotta, Harumi</creatorcontrib><description>The aim of this study was to examine gastric motility and blood flow during nociceptive hypertonic saline injections (HS) in paraspinal muscles of urethane-anaesthetised rats. Gastric pressure was not affected by HS in intact or vagotomised conditions. After cervical spinalisation, it was decreased by injections at T13 or L6 but not T2. Moreover, HS injections at T13 produced greater gastric pressure decreases compared with L6 and T2 and increased gastric sympathetic nerve activity. Blood pressure and gastric blood flow were decreased by T13 injections in spinal cord intact but not spinalised rats. Besides, isotonic saline injections (non-nociceptive) produced non-significant or marginal effects. These results indicate that gastric motility is decreased by nociceptive input from paraspinal muscles in spinalised rats through activation of the gastric sympathetic nerve. Although gastric blood flow was also decreased by nociceptive stimulation at T13 in spinal cord intact rats, these changes seem to depend on blood pressure.</description><identifier>ISSN: 1880-6546</identifier><identifier>EISSN: 1880-6562</identifier><identifier>DOI: 10.1007/s12576-013-0288-1</identifier><identifier>PMID: 24037728</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Anesthetics, Intravenous - adverse effects ; Animals ; Blood Pressure - physiology ; Gastrointestinal Motility - physiology ; Gastrointestinal Tract - blood supply ; Injections ; Lumbar Vertebrae - innervation ; Male ; Models, Animal ; Nociceptors - drug effects ; Nociceptors - physiology ; Original Paper ; Paraspinal Muscles - drug effects ; Paraspinal Muscles - innervation ; Paraspinal Muscles - physiology ; Rats ; Rats, Wistar ; Regional Blood Flow - physiology ; Saline Solution, Hypertonic - administration & dosage ; Saline Solution, Hypertonic - pharmacology ; Sympathetic Nervous System - physiology ; Thoracic Vertebrae - innervation ; Unconsciousness - chemically induced ; Urethane - adverse effects</subject><ispartof>The journal of physiological sciences, 2014-01, Vol.64 (1), p.37-46</ispartof><rights>The Physiological Society of Japan and Springer Japan 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-d0830922ae0579af85b8c48dfec1ed00958388c2afb1d5978ff62b22a0159633</citedby><cites>FETCH-LOGICAL-c424t-d0830922ae0579af85b8c48dfec1ed00958388c2afb1d5978ff62b22a0159633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717917/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717917/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24037728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Piché, Mathieu</creatorcontrib><creatorcontrib>Watanabe, Nobuhiro</creatorcontrib><creatorcontrib>Hotta, Harumi</creatorcontrib><title>Regulation of gastric motility and blood flow during acute nociceptive stimulation of the paraspinal muscles in urethane-anaesthetised rats</title><title>The journal of physiological sciences</title><addtitle>J Physiol Sci</addtitle><description>The aim of this study was to examine gastric motility and blood flow during nociceptive hypertonic saline injections (HS) in paraspinal muscles of urethane-anaesthetised rats. Gastric pressure was not affected by HS in intact or vagotomised conditions. After cervical spinalisation, it was decreased by injections at T13 or L6 but not T2. Moreover, HS injections at T13 produced greater gastric pressure decreases compared with L6 and T2 and increased gastric sympathetic nerve activity. Blood pressure and gastric blood flow were decreased by T13 injections in spinal cord intact but not spinalised rats. Besides, isotonic saline injections (non-nociceptive) produced non-significant or marginal effects. These results indicate that gastric motility is decreased by nociceptive input from paraspinal muscles in spinalised rats through activation of the gastric sympathetic nerve. Although gastric blood flow was also decreased by nociceptive stimulation at T13 in spinal cord intact rats, these changes seem to depend on blood pressure.</description><subject>Anesthetics, Intravenous - adverse effects</subject><subject>Animals</subject><subject>Blood Pressure - physiology</subject><subject>Gastrointestinal Motility - physiology</subject><subject>Gastrointestinal Tract - blood supply</subject><subject>Injections</subject><subject>Lumbar Vertebrae - innervation</subject><subject>Male</subject><subject>Models, Animal</subject><subject>Nociceptors - drug effects</subject><subject>Nociceptors - physiology</subject><subject>Original Paper</subject><subject>Paraspinal Muscles - drug effects</subject><subject>Paraspinal Muscles - innervation</subject><subject>Paraspinal Muscles - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Regional Blood Flow - physiology</subject><subject>Saline Solution, Hypertonic - administration & dosage</subject><subject>Saline Solution, Hypertonic - pharmacology</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Thoracic Vertebrae - innervation</subject><subject>Unconsciousness - chemically induced</subject><subject>Urethane - adverse effects</subject><issn>1880-6546</issn><issn>1880-6562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkd9qFTEQh4MotlYfwBvJC6xOsn-SvRIpVoWCIL0Ps8nknMhusiTZSp_Bl3bL0UO9moH5_b65-Bh7K-C9AFAfipC9GhoQbQNS60Y8Y5dCa2iGfpDPz3s3XLBXpfwE6IZR6pfsQnbQKiX1Jfv9gw7bjDWkyJPnByw1B8uXVMMc6gPH6Pg0p-S4n9Mv7rYc4oGj3SrxmGywtNZwT7zUsDzh1CPxFTOWNUSc-bIVO1PhIfItUz1ipAYjUtlzNRRyPGMtr9kLj3OhN3_nFbu7-Xx3_bW5_f7l2_Wn28Z2squNA93CKCUS9GpEr_tJ2047T1aQAxh73WptJfpJuH5U2vtBTnseRD8ObXvFPp6w6zYt5CzFmnE2aw4L5geTMJj_LzEczSHdGwFKqFGonSBOBJtTKZn8uSzAPJoxJzNmN2MezRixd949_Xpu_FPR_gFr047Z</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Piché, Mathieu</creator><creator>Watanabe, Nobuhiro</creator><creator>Hotta, Harumi</creator><general>Springer Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20140101</creationdate><title>Regulation of gastric motility and blood flow during acute nociceptive stimulation of the paraspinal muscles in urethane-anaesthetised rats</title><author>Piché, Mathieu ; Watanabe, Nobuhiro ; Hotta, Harumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-d0830922ae0579af85b8c48dfec1ed00958388c2afb1d5978ff62b22a0159633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Anesthetics, Intravenous - adverse effects</topic><topic>Animals</topic><topic>Blood Pressure - physiology</topic><topic>Gastrointestinal Motility - physiology</topic><topic>Gastrointestinal Tract - blood supply</topic><topic>Injections</topic><topic>Lumbar Vertebrae - innervation</topic><topic>Male</topic><topic>Models, Animal</topic><topic>Nociceptors - drug effects</topic><topic>Nociceptors - physiology</topic><topic>Original Paper</topic><topic>Paraspinal Muscles - drug effects</topic><topic>Paraspinal Muscles - innervation</topic><topic>Paraspinal Muscles - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Regional Blood Flow - physiology</topic><topic>Saline Solution, Hypertonic - administration & dosage</topic><topic>Saline Solution, Hypertonic - pharmacology</topic><topic>Sympathetic Nervous System - physiology</topic><topic>Thoracic Vertebrae - innervation</topic><topic>Unconsciousness - chemically induced</topic><topic>Urethane - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Piché, Mathieu</creatorcontrib><creatorcontrib>Watanabe, Nobuhiro</creatorcontrib><creatorcontrib>Hotta, Harumi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of physiological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Piché, Mathieu</au><au>Watanabe, Nobuhiro</au><au>Hotta, Harumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of gastric motility and blood flow during acute nociceptive stimulation of the paraspinal muscles in urethane-anaesthetised rats</atitle><jtitle>The journal of physiological sciences</jtitle><addtitle>J Physiol Sci</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>64</volume><issue>1</issue><spage>37</spage><epage>46</epage><pages>37-46</pages><issn>1880-6546</issn><eissn>1880-6562</eissn><abstract>The aim of this study was to examine gastric motility and blood flow during nociceptive hypertonic saline injections (HS) in paraspinal muscles of urethane-anaesthetised rats. Gastric pressure was not affected by HS in intact or vagotomised conditions. After cervical spinalisation, it was decreased by injections at T13 or L6 but not T2. Moreover, HS injections at T13 produced greater gastric pressure decreases compared with L6 and T2 and increased gastric sympathetic nerve activity. Blood pressure and gastric blood flow were decreased by T13 injections in spinal cord intact but not spinalised rats. Besides, isotonic saline injections (non-nociceptive) produced non-significant or marginal effects. These results indicate that gastric motility is decreased by nociceptive input from paraspinal muscles in spinalised rats through activation of the gastric sympathetic nerve. Although gastric blood flow was also decreased by nociceptive stimulation at T13 in spinal cord intact rats, these changes seem to depend on blood pressure.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>24037728</pmid><doi>10.1007/s12576-013-0288-1</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1880-6546 |
| ispartof | The journal of physiological sciences, 2014-01, Vol.64 (1), p.37-46 |
| issn | 1880-6546 1880-6562 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10717917 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerNature Journals; PubMed Central |
| subjects | Anesthetics, Intravenous - adverse effects Animals Blood Pressure - physiology Gastrointestinal Motility - physiology Gastrointestinal Tract - blood supply Injections Lumbar Vertebrae - innervation Male Models, Animal Nociceptors - drug effects Nociceptors - physiology Original Paper Paraspinal Muscles - drug effects Paraspinal Muscles - innervation Paraspinal Muscles - physiology Rats Rats, Wistar Regional Blood Flow - physiology Saline Solution, Hypertonic - administration & dosage Saline Solution, Hypertonic - pharmacology Sympathetic Nervous System - physiology Thoracic Vertebrae - innervation Unconsciousness - chemically induced Urethane - adverse effects |
| title | Regulation of gastric motility and blood flow during acute nociceptive stimulation of the paraspinal muscles in urethane-anaesthetised rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T01%3A37%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Regulation%20of%20gastric%20motility%20and%20blood%20flow%20during%20acute%20nociceptive%20stimulation%20of%20the%20paraspinal%20muscles%20in%20urethane-anaesthetised%20rats&rft.jtitle=The%20journal%20of%20physiological%20sciences&rft.au=Pich%C3%A9,%20Mathieu&rft.date=2014-01-01&rft.volume=64&rft.issue=1&rft.spage=37&rft.epage=46&rft.pages=37-46&rft.issn=1880-6546&rft.eissn=1880-6562&rft_id=info:doi/10.1007/s12576-013-0288-1&rft_dat=%3Cpubmed_cross%3E24037728%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/24037728&rfr_iscdi=true |