BDNF levels are increased in peripheral blood of middle-aged amateur runners with no changes on histone H4 acetylation levels
Our aim was to compare the basal levels of plasma brain-derived neurotrophic factor (BDNF) and global histone H4 acetylation in peripheral blood mononuclear cells (PBMCs) of healthy amateur runners (EXE group) with sedentary individuals (SED group) as well as to investigate the acute effect of a run...
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| Veröffentlicht in: | The journal of physiological sciences 2017-11, Vol.67 (6), p.681-687 |
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| container_title | The journal of physiological sciences |
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| creator | da Silveira, Fernanda Peres Basso, Carla Raupp, Wagner Dalpiaz, Morgana Bertoldi, Karine Siqueira, Ionara Rodrigues Lago, Pedro Dal de Souza, Maristela Padilha Elsner, Viviane Rostirola |
| description | Our aim was to compare the basal levels of plasma brain-derived neurotrophic factor (BDNF) and global histone H4 acetylation in peripheral blood mononuclear cells (PBMCs) of healthy amateur runners (EXE group) with sedentary individuals (SED group) as well as to investigate the acute effect of a running race on these markers in the EXE group. Five days before the race, all participants were submitted to a basal blood collection. On the race day, two blood samples were collected in the EXE group before the running started and immediately at the end. In the basal period, a significant increase of plasma BDNF levels in the EXE individuals when compared to the SED group (p = 0.036) was demonstrated, while no difference in global histone H4 acetylation levels was observed. These parameters were unaltered in the EXE group after the race. The increased levels of BDNF might be linked to healthy middle-aged runners' phenotype. |
| doi_str_mv | 10.1007/s12576-016-0496-6 |
| format | Article |
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Five days before the race, all participants were submitted to a basal blood collection. On the race day, two blood samples were collected in the EXE group before the running started and immediately at the end. In the basal period, a significant increase of plasma BDNF levels in the EXE individuals when compared to the SED group (p = 0.036) was demonstrated, while no difference in global histone H4 acetylation levels was observed. These parameters were unaltered in the EXE group after the race. The increased levels of BDNF might be linked to healthy middle-aged runners' phenotype.</description><identifier>ISSN: 1880-6546</identifier><identifier>EISSN: 1880-6562</identifier><identifier>DOI: 10.1007/s12576-016-0496-6</identifier><identifier>PMID: 27743179</identifier><language>eng</language><publisher>Japan: Springer</publisher><subject>Acetylation ; Adult ; Blood banks ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - blood ; Brain-Derived Neurotrophic Factor - metabolism ; Case-Control Studies ; Epigenetic inheritance ; Histone H4 ; Histones - blood ; Histones - metabolism ; Humans ; Leukocytes (mononuclear) ; Leukocytes, Mononuclear - metabolism ; Male ; Middle age ; Middle Aged ; Original Paper ; Peripheral blood mononuclear cells ; Physical fitness ; Running ; Running - physiology ; Sedentary Behavior</subject><ispartof>The journal of physiological sciences, 2017-11, Vol.67 (6), p.681-687</ispartof><rights>COPYRIGHT 2016 Springer</rights><rights>Copyright Springer Science & Business Media 2017</rights><rights>The Physiological Society of Japan and Springer Japan 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-bf7ca83eb47a90540e4ab0a1e8b2d2ba1d79bc474a347c1fd56fb5790b1486a13</citedby><cites>FETCH-LOGICAL-c557t-bf7ca83eb47a90540e4ab0a1e8b2d2ba1d79bc474a347c1fd56fb5790b1486a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717784/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717784/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27743179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>da Silveira, Fernanda Peres</creatorcontrib><creatorcontrib>Basso, Carla</creatorcontrib><creatorcontrib>Raupp, Wagner</creatorcontrib><creatorcontrib>Dalpiaz, Morgana</creatorcontrib><creatorcontrib>Bertoldi, Karine</creatorcontrib><creatorcontrib>Siqueira, Ionara Rodrigues</creatorcontrib><creatorcontrib>Lago, Pedro Dal</creatorcontrib><creatorcontrib>de Souza, Maristela Padilha</creatorcontrib><creatorcontrib>Elsner, Viviane Rostirola</creatorcontrib><title>BDNF levels are increased in peripheral blood of middle-aged amateur runners with no changes on histone H4 acetylation levels</title><title>The journal of physiological sciences</title><addtitle>J Physiol Sci</addtitle><description>Our aim was to compare the basal levels of plasma brain-derived neurotrophic factor (BDNF) and global histone H4 acetylation in peripheral blood mononuclear cells (PBMCs) of healthy amateur runners (EXE group) with sedentary individuals (SED group) as well as to investigate the acute effect of a running race on these markers in the EXE group. Five days before the race, all participants were submitted to a basal blood collection. On the race day, two blood samples were collected in the EXE group before the running started and immediately at the end. In the basal period, a significant increase of plasma BDNF levels in the EXE individuals when compared to the SED group (p = 0.036) was demonstrated, while no difference in global histone H4 acetylation levels was observed. These parameters were unaltered in the EXE group after the race. The increased levels of BDNF might be linked to healthy middle-aged runners' phenotype.</description><subject>Acetylation</subject><subject>Adult</subject><subject>Blood banks</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - blood</subject><subject>Brain-Derived Neurotrophic Factor - metabolism</subject><subject>Case-Control Studies</subject><subject>Epigenetic inheritance</subject><subject>Histone H4</subject><subject>Histones - blood</subject><subject>Histones - metabolism</subject><subject>Humans</subject><subject>Leukocytes (mononuclear)</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Male</subject><subject>Middle age</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Peripheral blood mononuclear cells</subject><subject>Physical fitness</subject><subject>Running</subject><subject>Running - physiology</subject><subject>Sedentary Behavior</subject><issn>1880-6546</issn><issn>1880-6562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptUsFu1DAQjRCIlsIHcEGWuHBJsRPHTk6oFNoiVXCBszV2Jokrx17spKgH_h2vtl0oWlmWR-P33mhmXlG8ZvSUUSrfJ1Y1UpSU5cs7UYonxTFrW1qKRlRP9zEXR8WLlG4o5aKr2ufFUSUlr5nsjovfHz99vSAOb9ElAhGJ9SYiJOxzRDYY7WbCCI5oF0JPwkBm2_cOSxgzBGZYcI0krt5jTOSXXSbiAzET-BETCZ5MNi3BI7niBAwudw4Wm9O7ii-LZwO4hK_u35Pix8Xn7-dX5fW3yy_nZ9elaRq5lHqQBtoaNZfQ0YZT5KApMGx11VcaWC87bbjkUHNp2NA3YtCN7KhmvBXA6pPiw053s-oZe4N-yT2pTbQzxDsVwKrHP95Oagy3ilHJpGx5Vnh3rxDDzxXTomabDDoHHsOaFGvrhjNJaZ2hb_-D3oQ1-tyfYl2Td1BxXv1FjeBQWT-EXNhsRdWZFE1dSda1GVUeQI3otzvJYx1sTj_Cnx7A59PjbM1BAtsRTAwpRRz2Q2FUbU2mdiZT2WRqazIlMufNv9PcMx5cVf8BvbjM5A</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>da Silveira, Fernanda Peres</creator><creator>Basso, Carla</creator><creator>Raupp, Wagner</creator><creator>Dalpiaz, Morgana</creator><creator>Bertoldi, Karine</creator><creator>Siqueira, Ionara Rodrigues</creator><creator>Lago, Pedro Dal</creator><creator>de Souza, Maristela Padilha</creator><creator>Elsner, Viviane Rostirola</creator><general>Springer</general><general>BioMed Central</general><general>Springer Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171101</creationdate><title>BDNF levels are increased in peripheral blood of middle-aged amateur runners with no changes on histone H4 acetylation levels</title><author>da Silveira, Fernanda Peres ; Basso, Carla ; Raupp, Wagner ; Dalpiaz, Morgana ; Bertoldi, Karine ; Siqueira, Ionara Rodrigues ; Lago, Pedro Dal ; de Souza, Maristela Padilha ; Elsner, Viviane Rostirola</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c557t-bf7ca83eb47a90540e4ab0a1e8b2d2ba1d79bc474a347c1fd56fb5790b1486a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acetylation</topic><topic>Adult</topic><topic>Blood banks</topic><topic>Brain-derived neurotrophic factor</topic><topic>Brain-Derived Neurotrophic Factor - blood</topic><topic>Brain-Derived Neurotrophic Factor - metabolism</topic><topic>Case-Control Studies</topic><topic>Epigenetic inheritance</topic><topic>Histone H4</topic><topic>Histones - blood</topic><topic>Histones - metabolism</topic><topic>Humans</topic><topic>Leukocytes (mononuclear)</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Male</topic><topic>Middle age</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>Peripheral blood mononuclear cells</topic><topic>Physical fitness</topic><topic>Running</topic><topic>Running - physiology</topic><topic>Sedentary Behavior</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>da Silveira, Fernanda Peres</creatorcontrib><creatorcontrib>Basso, Carla</creatorcontrib><creatorcontrib>Raupp, Wagner</creatorcontrib><creatorcontrib>Dalpiaz, Morgana</creatorcontrib><creatorcontrib>Bertoldi, Karine</creatorcontrib><creatorcontrib>Siqueira, Ionara Rodrigues</creatorcontrib><creatorcontrib>Lago, Pedro Dal</creatorcontrib><creatorcontrib>de Souza, Maristela Padilha</creatorcontrib><creatorcontrib>Elsner, Viviane Rostirola</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of physiological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>da Silveira, Fernanda Peres</au><au>Basso, Carla</au><au>Raupp, Wagner</au><au>Dalpiaz, Morgana</au><au>Bertoldi, Karine</au><au>Siqueira, Ionara Rodrigues</au><au>Lago, Pedro Dal</au><au>de Souza, Maristela Padilha</au><au>Elsner, Viviane Rostirola</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BDNF levels are increased in peripheral blood of middle-aged amateur runners with no changes on histone H4 acetylation levels</atitle><jtitle>The journal of physiological sciences</jtitle><addtitle>J Physiol Sci</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>67</volume><issue>6</issue><spage>681</spage><epage>687</epage><pages>681-687</pages><issn>1880-6546</issn><eissn>1880-6562</eissn><abstract>Our aim was to compare the basal levels of plasma brain-derived neurotrophic factor (BDNF) and global histone H4 acetylation in peripheral blood mononuclear cells (PBMCs) of healthy amateur runners (EXE group) with sedentary individuals (SED group) as well as to investigate the acute effect of a running race on these markers in the EXE group. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Acetylation Adult Blood banks Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - blood Brain-Derived Neurotrophic Factor - metabolism Case-Control Studies Epigenetic inheritance Histone H4 Histones - blood Histones - metabolism Humans Leukocytes (mononuclear) Leukocytes, Mononuclear - metabolism Male Middle age Middle Aged Original Paper Peripheral blood mononuclear cells Physical fitness Running Running - physiology Sedentary Behavior |
| title | BDNF levels are increased in peripheral blood of middle-aged amateur runners with no changes on histone H4 acetylation levels |
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