The mechanism of increased postnatal heart rate and sinoatrial node pacemaker activity in mice
Heart rate (HR) of mammalian species changes postnatally, i.e., HR of large animals including humans decreases, while HR in small animals such as mice and rats increases. To clarify cellular mechanisms underlying the postnatal HR changes, we performed in vivo HR measurement and electrophysiological...
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| Veröffentlicht in: | The journal of physiological sciences 2013-03, Vol.63 (2), p.133-146 |
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| creator | Adachi, Takeshi Shibata, Shigehiro Okamoto, Yosuke Sato, Shinichi Fujisawa, Susumu Ohba, Takayoshi Ono, Kyoichi |
| description | Heart rate (HR) of mammalian species changes postnatally, i.e., HR of large animals including humans decreases, while HR in small animals such as mice and rats increases. To clarify cellular mechanisms underlying the postnatal HR changes, we performed in vivo HR measurement and electrophysiological analysis on sinoatrial node (SAN) cells in mice. The in vivo HR was ~320 beats min−1 (bpm) immediately after birth, and increased with age to ~690 bpm at postnatal day 14. Under blockage of autonomic nervous systems, HR remained constant until postnatal day 5 and then increased day by day. The spontaneous beating rate of SAN preparation showed a similar postnatal change. The density of the L-type Ca2+ current (LCC) was smaller in neonatal SAN cells than in adult cells, accompanied by a positive shift of voltage-dependent activation. Thus, the postnatal increase in HR is caused by both the increased sympathetic influence and the intrinsic activity of SAN cells. The different conductance and kinetics of LCC may be involved in the postnatal increase in pacemaker activity. |
| doi_str_mv | 10.1007/s12576-012-0248-1 |
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To clarify cellular mechanisms underlying the postnatal HR changes, we performed in vivo HR measurement and electrophysiological analysis on sinoatrial node (SAN) cells in mice. The in vivo HR was ~320 beats min−1 (bpm) immediately after birth, and increased with age to ~690 bpm at postnatal day 14. Under blockage of autonomic nervous systems, HR remained constant until postnatal day 5 and then increased day by day. The spontaneous beating rate of SAN preparation showed a similar postnatal change. The density of the L-type Ca2+ current (LCC) was smaller in neonatal SAN cells than in adult cells, accompanied by a positive shift of voltage-dependent activation. Thus, the postnatal increase in HR is caused by both the increased sympathetic influence and the intrinsic activity of SAN cells. The different conductance and kinetics of LCC may be involved in the postnatal increase in pacemaker activity.</description><identifier>ISSN: 1880-6546</identifier><identifier>EISSN: 1880-6562</identifier><identifier>DOI: 10.1007/s12576-012-0248-1</identifier><identifier>PMID: 23288563</identifier><language>eng</language><publisher>Japan: Elsevier Inc</publisher><subject>Action Potentials ; Age Factors ; Animals ; Animals, Newborn ; Biological Clocks - drug effects ; Ca2+ current ; Calcium - metabolism ; Calcium Channels, L-Type - genetics ; Calcium Channels, L-Type - metabolism ; Cardiac automaticity ; Cyclic Nucleotide-Gated Cation Channels - genetics ; Cyclic Nucleotide-Gated Cation Channels - metabolism ; Development ; Female ; Gene Expression Regulation ; Heart rate ; Heart Rate - drug effects ; Hyperpolarization-activated cation channel ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels ; Ion Channel Gating ; Kinetics ; Male ; Membrane Transport Modulators - pharmacology ; Mice ; Mice, Inbred C57BL ; Original Paper ; Patch-Clamp Techniques ; Sinoatrial node ; Sinoatrial Node - cytology ; Sinoatrial Node - drug effects ; Sinoatrial Node - innervation ; Sinoatrial Node - metabolism ; Sinoatrial Node - physiology ; Sympathetic Nervous System - physiology</subject><ispartof>The journal of physiological sciences, 2013-03, Vol.63 (2), p.133-146</ispartof><rights>2013 The Physiological Society of Japan and Springer Japan</rights><rights>The Physiological Society of Japan and Springer Japan 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c569t-e16614947bf9d589912352f2b94b03b2b0a07a9cc1935712a5abb5e414c1ed13</citedby><cites>FETCH-LOGICAL-c569t-e16614947bf9d589912352f2b94b03b2b0a07a9cc1935712a5abb5e414c1ed13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717579/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717579/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23288563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adachi, Takeshi</creatorcontrib><creatorcontrib>Shibata, Shigehiro</creatorcontrib><creatorcontrib>Okamoto, Yosuke</creatorcontrib><creatorcontrib>Sato, Shinichi</creatorcontrib><creatorcontrib>Fujisawa, Susumu</creatorcontrib><creatorcontrib>Ohba, Takayoshi</creatorcontrib><creatorcontrib>Ono, Kyoichi</creatorcontrib><title>The mechanism of increased postnatal heart rate and sinoatrial node pacemaker activity in mice</title><title>The journal of physiological sciences</title><addtitle>J Physiol Sci</addtitle><description>Heart rate (HR) of mammalian species changes postnatally, i.e., HR of large animals including humans decreases, while HR in small animals such as mice and rats increases. To clarify cellular mechanisms underlying the postnatal HR changes, we performed in vivo HR measurement and electrophysiological analysis on sinoatrial node (SAN) cells in mice. The in vivo HR was ~320 beats min−1 (bpm) immediately after birth, and increased with age to ~690 bpm at postnatal day 14. Under blockage of autonomic nervous systems, HR remained constant until postnatal day 5 and then increased day by day. The spontaneous beating rate of SAN preparation showed a similar postnatal change. The density of the L-type Ca2+ current (LCC) was smaller in neonatal SAN cells than in adult cells, accompanied by a positive shift of voltage-dependent activation. Thus, the postnatal increase in HR is caused by both the increased sympathetic influence and the intrinsic activity of SAN cells. The different conductance and kinetics of LCC may be involved in the postnatal increase in pacemaker activity.</description><subject>Action Potentials</subject><subject>Age Factors</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biological Clocks - drug effects</subject><subject>Ca2+ current</subject><subject>Calcium - metabolism</subject><subject>Calcium Channels, L-Type - genetics</subject><subject>Calcium Channels, L-Type - metabolism</subject><subject>Cardiac automaticity</subject><subject>Cyclic Nucleotide-Gated Cation Channels - genetics</subject><subject>Cyclic Nucleotide-Gated Cation Channels - metabolism</subject><subject>Development</subject><subject>Female</subject><subject>Gene Expression Regulation</subject><subject>Heart rate</subject><subject>Heart Rate - drug effects</subject><subject>Hyperpolarization-activated cation channel</subject><subject>Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels</subject><subject>Ion Channel Gating</subject><subject>Kinetics</subject><subject>Male</subject><subject>Membrane Transport Modulators - pharmacology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Original Paper</subject><subject>Patch-Clamp Techniques</subject><subject>Sinoatrial node</subject><subject>Sinoatrial Node - cytology</subject><subject>Sinoatrial Node - drug effects</subject><subject>Sinoatrial Node - innervation</subject><subject>Sinoatrial Node - metabolism</subject><subject>Sinoatrial Node - physiology</subject><subject>Sympathetic Nervous System - physiology</subject><issn>1880-6546</issn><issn>1880-6562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1r3DAQhkVpaT7aH9BL0TEXtxrZki1yCCG0TSHQy54rxvK4q9aWNpJ2If8-XjZZkktPGph3Hg3zMPYJxBcQov2aQapWVwJkJWTTVfCGnULXiUorLd8e60afsLOc_wrRaCO79-xE1rLrlK5P2e_VmvhMbo3B55nHkfvgEmGmgW9iLgELTnxNmApPWIhjGHj2IWJJfumEOBDfoKMZ_1Hi6Irf-fKwUPjsHX1g70acMn18es_Z6vu31c1tdffrx8-b67vKKW1KRaA1NKZp-9EMqjMGZK3kKHvT9KLuZS9QtGicA1OrFiQq7HtFDTQOaID6nF0dsJttP9PgKJSEk90kP2N6sBG9fd0Jfm3_xJ0F0UKrWrMQLp4IKd5vKRc7--xomjBQ3GYLNUitBeh9FA5Rl2LOicbjPyDs3os9eLGLF7v3YvcLfn654HHiWcQSuDwEaLnSzlOy2XkKjgafyBU7RP8f_CMdT51b</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Adachi, Takeshi</creator><creator>Shibata, Shigehiro</creator><creator>Okamoto, Yosuke</creator><creator>Sato, Shinichi</creator><creator>Fujisawa, Susumu</creator><creator>Ohba, Takayoshi</creator><creator>Ono, Kyoichi</creator><general>Elsevier Inc</general><general>Springer Japan</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130301</creationdate><title>The mechanism of increased postnatal heart rate and sinoatrial node pacemaker activity in mice</title><author>Adachi, Takeshi ; Shibata, Shigehiro ; Okamoto, Yosuke ; Sato, Shinichi ; Fujisawa, Susumu ; Ohba, Takayoshi ; Ono, Kyoichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c569t-e16614947bf9d589912352f2b94b03b2b0a07a9cc1935712a5abb5e414c1ed13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Action Potentials</topic><topic>Age Factors</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biological Clocks - drug effects</topic><topic>Ca2+ current</topic><topic>Calcium - metabolism</topic><topic>Calcium Channels, L-Type - genetics</topic><topic>Calcium Channels, L-Type - metabolism</topic><topic>Cardiac automaticity</topic><topic>Cyclic Nucleotide-Gated Cation Channels - genetics</topic><topic>Cyclic Nucleotide-Gated Cation Channels - metabolism</topic><topic>Development</topic><topic>Female</topic><topic>Gene Expression Regulation</topic><topic>Heart rate</topic><topic>Heart Rate - drug effects</topic><topic>Hyperpolarization-activated cation channel</topic><topic>Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels</topic><topic>Ion Channel Gating</topic><topic>Kinetics</topic><topic>Male</topic><topic>Membrane Transport Modulators - pharmacology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Original Paper</topic><topic>Patch-Clamp Techniques</topic><topic>Sinoatrial node</topic><topic>Sinoatrial Node - cytology</topic><topic>Sinoatrial Node - drug effects</topic><topic>Sinoatrial Node - innervation</topic><topic>Sinoatrial Node - metabolism</topic><topic>Sinoatrial Node - physiology</topic><topic>Sympathetic Nervous System - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adachi, Takeshi</creatorcontrib><creatorcontrib>Shibata, Shigehiro</creatorcontrib><creatorcontrib>Okamoto, Yosuke</creatorcontrib><creatorcontrib>Sato, Shinichi</creatorcontrib><creatorcontrib>Fujisawa, Susumu</creatorcontrib><creatorcontrib>Ohba, Takayoshi</creatorcontrib><creatorcontrib>Ono, Kyoichi</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of physiological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adachi, Takeshi</au><au>Shibata, Shigehiro</au><au>Okamoto, Yosuke</au><au>Sato, Shinichi</au><au>Fujisawa, Susumu</au><au>Ohba, Takayoshi</au><au>Ono, Kyoichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The mechanism of increased postnatal heart rate and sinoatrial node pacemaker activity in mice</atitle><jtitle>The journal of physiological sciences</jtitle><addtitle>J Physiol Sci</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>63</volume><issue>2</issue><spage>133</spage><epage>146</epage><pages>133-146</pages><issn>1880-6546</issn><eissn>1880-6562</eissn><abstract>Heart rate (HR) of mammalian species changes postnatally, i.e., HR of large animals including humans decreases, while HR in small animals such as mice and rats increases. To clarify cellular mechanisms underlying the postnatal HR changes, we performed in vivo HR measurement and electrophysiological analysis on sinoatrial node (SAN) cells in mice. The in vivo HR was ~320 beats min−1 (bpm) immediately after birth, and increased with age to ~690 bpm at postnatal day 14. Under blockage of autonomic nervous systems, HR remained constant until postnatal day 5 and then increased day by day. The spontaneous beating rate of SAN preparation showed a similar postnatal change. The density of the L-type Ca2+ current (LCC) was smaller in neonatal SAN cells than in adult cells, accompanied by a positive shift of voltage-dependent activation. Thus, the postnatal increase in HR is caused by both the increased sympathetic influence and the intrinsic activity of SAN cells. 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| subjects | Action Potentials Age Factors Animals Animals, Newborn Biological Clocks - drug effects Ca2+ current Calcium - metabolism Calcium Channels, L-Type - genetics Calcium Channels, L-Type - metabolism Cardiac automaticity Cyclic Nucleotide-Gated Cation Channels - genetics Cyclic Nucleotide-Gated Cation Channels - metabolism Development Female Gene Expression Regulation Heart rate Heart Rate - drug effects Hyperpolarization-activated cation channel Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels Ion Channel Gating Kinetics Male Membrane Transport Modulators - pharmacology Mice Mice, Inbred C57BL Original Paper Patch-Clamp Techniques Sinoatrial node Sinoatrial Node - cytology Sinoatrial Node - drug effects Sinoatrial Node - innervation Sinoatrial Node - metabolism Sinoatrial Node - physiology Sympathetic Nervous System - physiology |
| title | The mechanism of increased postnatal heart rate and sinoatrial node pacemaker activity in mice |
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