Sex differences in baroreflex function in health and disease
This brief review summarizes the current knowledge on sex differences in baroreflex function, with a major focus on studies in humans. It has been demonstrated that healthy women have blunted cardiovagal baroreflx sensitivity during a rapid (i.e., within seconds) hypertensive stimulus, but barorefle...
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| Veröffentlicht in: | The journal of physiological sciences 2019-11, Vol.69 (6), p.851-859 |
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| description | This brief review summarizes the current knowledge on sex differences in baroreflex function, with a major focus on studies in humans. It has been demonstrated that healthy women have blunted cardiovagal baroreflx sensitivity during a rapid (i.e., within seconds) hypertensive stimulus, but baroreflex sensitivity is similar between the sexes during a hypotensive stimulus. Normal aging decreases cardiovagal baroreflex sensitivity and the rate of decline is similar in men and women. Cardiovagal baroreflex sensitivity is reduced in pathological conditions such as hypertension and type II diabetes, and the reduction is greater in female patients than male patients. There is no clear sex difference in sympathetic baroreflex sensitivity among young individuals, however, with women of more advanced age, sympathetic baroreflex sensitivity decreases, which appears to be associated with greater arterial stiffness compared with similarly aged men. The blunted sympathetic baroreflex sensitivity in older women may predispose them to an increased prevalence of hypertension and cardiovascular disease. |
| doi_str_mv | 10.1007/s12576-019-00727-z |
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It has been demonstrated that healthy women have blunted cardiovagal baroreflx sensitivity during a rapid (i.e., within seconds) hypertensive stimulus, but baroreflex sensitivity is similar between the sexes during a hypotensive stimulus. Normal aging decreases cardiovagal baroreflex sensitivity and the rate of decline is similar in men and women. Cardiovagal baroreflex sensitivity is reduced in pathological conditions such as hypertension and type II diabetes, and the reduction is greater in female patients than male patients. There is no clear sex difference in sympathetic baroreflex sensitivity among young individuals, however, with women of more advanced age, sympathetic baroreflex sensitivity decreases, which appears to be associated with greater arterial stiffness compared with similarly aged men. The blunted sympathetic baroreflex sensitivity in older women may predispose them to an increased prevalence of hypertension and cardiovascular disease.</description><identifier>ISSN: 1880-6546</identifier><identifier>EISSN: 1880-6562</identifier><identifier>DOI: 10.1007/s12576-019-00727-z</identifier><identifier>PMID: 31721084</identifier><language>eng</language><publisher>Japan: Springer</publisher><subject>Aging ; Baroreceptors ; Baroreflex - physiology ; Beta blockers ; Blood pressure ; Cardiovascular diseases ; Cardiovascular Diseases - pathology ; Diabetes mellitus ; Estrogens ; Female ; Gender differences ; Health aspects ; Heart rate ; Hormones ; Humans ; Hypertension ; Male ; Menstruation ; Physiology ; Reflexes ; Review ; Sex differences ; Sex Factors ; Sexes ; Sympathetic Nervous System - physiology ; Women ; Womens health ; Young adults</subject><ispartof>The journal of physiological sciences, 2019-11, Vol.69 (6), p.851-859</ispartof><rights>COPYRIGHT 2019 Springer</rights><rights>Copyright Springer Nature B.V. 2019</rights><rights>2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</rights><rights>The Physiological Society of Japan and Springer Japan KK, part of Springer Nature 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c681t-b4975e6e219e1d71022347fb9cfda011af9d0631303a69151fdcc40e75b4a923</citedby><cites>FETCH-LOGICAL-c681t-b4975e6e219e1d71022347fb9cfda011af9d0631303a69151fdcc40e75b4a923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717578/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717578/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31721084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fu, Qi</creatorcontrib><creatorcontrib>Ogoh, Shigehiko</creatorcontrib><title>Sex differences in baroreflex function in health and disease</title><title>The journal of physiological sciences</title><addtitle>J Physiol Sci</addtitle><description>This brief review summarizes the current knowledge on sex differences in baroreflex function, with a major focus on studies in humans. It has been demonstrated that healthy women have blunted cardiovagal baroreflx sensitivity during a rapid (i.e., within seconds) hypertensive stimulus, but baroreflex sensitivity is similar between the sexes during a hypotensive stimulus. Normal aging decreases cardiovagal baroreflex sensitivity and the rate of decline is similar in men and women. Cardiovagal baroreflex sensitivity is reduced in pathological conditions such as hypertension and type II diabetes, and the reduction is greater in female patients than male patients. There is no clear sex difference in sympathetic baroreflex sensitivity among young individuals, however, with women of more advanced age, sympathetic baroreflex sensitivity decreases, which appears to be associated with greater arterial stiffness compared with similarly aged men. The blunted sympathetic baroreflex sensitivity in older women may predispose them to an increased prevalence of hypertension and cardiovascular disease.</description><subject>Aging</subject><subject>Baroreceptors</subject><subject>Baroreflex - physiology</subject><subject>Beta blockers</subject><subject>Blood pressure</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - pathology</subject><subject>Diabetes mellitus</subject><subject>Estrogens</subject><subject>Female</subject><subject>Gender differences</subject><subject>Health aspects</subject><subject>Heart rate</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Male</subject><subject>Menstruation</subject><subject>Physiology</subject><subject>Reflexes</subject><subject>Review</subject><subject>Sex differences</subject><subject>Sex Factors</subject><subject>Sexes</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Women</subject><subject>Womens health</subject><subject>Young adults</subject><issn>1880-6546</issn><issn>1880-6562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kl1rVDEQhoMo9vMPeCELXp-ayecJCFKKtkLBC3sfcnImuylnk5qcldpfb9qti4VFcpFk5nknw-Ql5B3QM6BUf6zApFYdBdO1K9PdwytyCH1POyUVe707C3VAjmq9pVQow_q35ICDZkB7cUg-_cD7xRhDwILJY13EtBhcyQXD1DJhk_wcc3oMr9BN82rh0tgEFV3FE_ImuKni6fN-TG6-frm5uOquv19-uzi_7rzqYe4GYbREhQwMwqiBMsaFDoPxYXQUwAUzUsWBU-6UAQlh9F5Q1HIQzjB-TD5vy95thjWOHtNc3GTvSly78ttmF-3LTIoru8y_LFANWuq-VfjwXKHknxuss73Nm5Jaz7aNUAoKDPh_Kc5obzRv2I5augltTCG3N_06Vm_PtZKcScFko7o91BITtgZzwhBb-AV_todva8R19HsFbCvwJdfavms3D6D20R52aw_b7GGf7GEfmuj9v5PcSf76gf8Bunyyzw</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Fu, Qi</creator><creator>Ogoh, Shigehiko</creator><general>Springer</general><general>BioMed Central</general><general>Springer Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20191101</creationdate><title>Sex differences in baroreflex function in health and disease</title><author>Fu, Qi ; 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It has been demonstrated that healthy women have blunted cardiovagal baroreflx sensitivity during a rapid (i.e., within seconds) hypertensive stimulus, but baroreflex sensitivity is similar between the sexes during a hypotensive stimulus. Normal aging decreases cardiovagal baroreflex sensitivity and the rate of decline is similar in men and women. Cardiovagal baroreflex sensitivity is reduced in pathological conditions such as hypertension and type II diabetes, and the reduction is greater in female patients than male patients. There is no clear sex difference in sympathetic baroreflex sensitivity among young individuals, however, with women of more advanced age, sympathetic baroreflex sensitivity decreases, which appears to be associated with greater arterial stiffness compared with similarly aged men. 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| subjects | Aging Baroreceptors Baroreflex - physiology Beta blockers Blood pressure Cardiovascular diseases Cardiovascular Diseases - pathology Diabetes mellitus Estrogens Female Gender differences Health aspects Heart rate Hormones Humans Hypertension Male Menstruation Physiology Reflexes Review Sex differences Sex Factors Sexes Sympathetic Nervous System - physiology Women Womens health Young adults |
| title | Sex differences in baroreflex function in health and disease |
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