Poly(ADP-ribose) polymerase 1 activation links ischemic acute kidney injury to interstitial fibrosis

Inactivation of poly(ADP-ribose) polymerase 1 (PARP1) has been found to be protective in several disease models; however, the role of PARP1 in acute kidney injury-induced interstitial fibrosis has not been studied. Herein, we tested whether PARP1 inactivation by treatment with PJ34 (a PARP1 inactiva...

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Veröffentlicht in:	The journal of physiological sciences 2015-01, Vol.65 (1), p.105-111
Hauptverfasser:	Yoon, Sang Pil, Kim, Jinu
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Acute kidney injury Acute Kidney Injury - drug therapy Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Animals Chemokine CCL2 - biosynthesis Chronic kidney injury Collagen Collagen - metabolism Enzyme Activation Enzyme Inhibitors - pharmacology Fibrosis Inflammation Interstitial fibrosis Ischemia-reperfusion injury Macrophage Macrophages - pathology Male Mice Mice, Inbred C57BL Monocyte chemotactic protein-1 Myofibroblasts - pathology Original Paper Phenanthrenes - pharmacology PJ34 Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases - metabolism Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Reperfusion Injury - pathology
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