Responses of cutaneous C-fiber afferents and spinal microglia after hindlimb cast immobilization in rats

Previous studies have shown that persistent limb immobilization using a cast increases nociceptive behavior to somatic stimuli in rats. However, the peripheral neural mechanisms of nociception remain unclear. Using single-fiber electrophysiological recordings in vitro, we examined the general charac...

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Veröffentlicht in:	The journal of physiological sciences 2021-06, Vol.71 (1), p.19-19, Article 19
Hauptverfasser:	Ota, Hiroki, Takebe, Haruna, Mizumura, Kazue, Taguchi, Toru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ankle Behavior C-fiber afferents Cast immobilization Casts, Surgical - adverse effects Dorsal horn Experiments Fibers Heat stimuli Hindlimb - physiology Hyperalgesia Hypersensitivity Immobilization Immobilization - adverse effects Male Mathematical models Microglia Microglia - physiology Nerve Fibers, Unmyelinated - physiology Neurons, Afferent - physiology Nociception - physiology Original Paper Pain Pain Measurement Pain perception Rats Rats, Sprague-Dawley Saphenous nerve Single-fiber recording Skin - innervation Spinal cord Spinal Cord - physiology Spinal microglia Statistical analysis
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