Transmural cellular heterogeneity in myocardial electromechanics
Myocardial heterogeneity is an attribute of the normal heart. We have developed integrative models of cardiomyocytes from the subendocardial (ENDO) and subepicardial (EPI) ventricular regions that take into account experimental data on specific regional features of intracellular electromechanical co...
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| Veröffentlicht in: | The journal of physiological sciences 2018-07, Vol.68 (4), p.387-413 |
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| creator | Khokhlova, Anastasia Balakina-Vikulova, Nathalie Katsnelson, Leonid Iribe, Gentaro Solovyova, Olga |
| description | Myocardial heterogeneity is an attribute of the normal heart. We have developed integrative models of cardiomyocytes from the subendocardial (ENDO) and subepicardial (EPI) ventricular regions that take into account experimental data on specific regional features of intracellular electromechanical coupling in the guinea pig heart. The models adequately simulate experimental data on the differences in the action potential and contraction between the ENDO and EPI cells. The modeling results predict that heterogeneity in the parameters of calcium handling and myofilament mechanics in isolated ENDO and EPI cardiomyocytes are essential to produce the differences in Ca2+ transients and contraction profiles via cooperative mechanisms of mechano-calcium-electric feedback and may further slightly modulate transmural differences in the electrical properties between the cells. Simulation results predict that ENDO cells have greater sensitivity to changes in the mechanical load than EPI cells. These data are important for understanding the behavior of cardiomyocytes in the intact heart. |
| doi_str_mv | 10.1007/s12576-017-0541-0 |
| format | Article |
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We have developed integrative models of cardiomyocytes from the subendocardial (ENDO) and subepicardial (EPI) ventricular regions that take into account experimental data on specific regional features of intracellular electromechanical coupling in the guinea pig heart. The models adequately simulate experimental data on the differences in the action potential and contraction between the ENDO and EPI cells. The modeling results predict that heterogeneity in the parameters of calcium handling and myofilament mechanics in isolated ENDO and EPI cardiomyocytes are essential to produce the differences in Ca2+ transients and contraction profiles via cooperative mechanisms of mechano-calcium-electric feedback and may further slightly modulate transmural differences in the electrical properties between the cells. Simulation results predict that ENDO cells have greater sensitivity to changes in the mechanical load than EPI cells. These data are important for understanding the behavior of cardiomyocytes in the intact heart.</description><identifier>ISSN: 1880-6546</identifier><identifier>EISSN: 1880-6562</identifier><identifier>DOI: 10.1007/s12576-017-0541-0</identifier><identifier>PMID: 28573594</identifier><language>eng</language><publisher>Japan: Elsevier Inc</publisher><subject>Action potential ; Action Potentials - physiology ; Analysis ; Animal models ; Animals ; Biomechanical Phenomena - physiology ; Calcium ; Calcium - metabolism ; Cardiac modeling ; Cardiac transmural heterogeneity ; Cardiology ; Cardiomyocyte ; Cardiomyocytes ; Contraction ; Electric properties ; Electrical properties ; Electromechanical coupling ; Guinea Pigs ; Heart ; Mechanical properties ; Mechano-calcium-electric feedback ; Models, Cardiovascular ; Myocardial Contraction - physiology ; Myocardium - metabolism ; Myocytes, Cardiac - physiology ; Original Paper ; Ventricle</subject><ispartof>The journal of physiological sciences, 2018-07, Vol.68 (4), p.387-413</ispartof><rights>2017 The Physiological Society of Japan and Springer Japan KK</rights><rights>COPYRIGHT 2017 Springer</rights><rights>Copyright Springer Nature B.V. 2018</rights><rights>The Physiological Society of Japan and Springer Japan 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c609t-d47c373e5a4ff71f9167db9d394ebf85a5f7998944ddd61395c818fd6eaf03673</citedby><cites>FETCH-LOGICAL-c609t-d47c373e5a4ff71f9167db9d394ebf85a5f7998944ddd61395c818fd6eaf03673</cites><orcidid>0000-0003-2966-8437</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717105/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717105/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28573594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khokhlova, Anastasia</creatorcontrib><creatorcontrib>Balakina-Vikulova, Nathalie</creatorcontrib><creatorcontrib>Katsnelson, Leonid</creatorcontrib><creatorcontrib>Iribe, Gentaro</creatorcontrib><creatorcontrib>Solovyova, Olga</creatorcontrib><title>Transmural cellular heterogeneity in myocardial electromechanics</title><title>The journal of physiological sciences</title><addtitle>J Physiol Sci</addtitle><description>Myocardial heterogeneity is an attribute of the normal heart. We have developed integrative models of cardiomyocytes from the subendocardial (ENDO) and subepicardial (EPI) ventricular regions that take into account experimental data on specific regional features of intracellular electromechanical coupling in the guinea pig heart. The models adequately simulate experimental data on the differences in the action potential and contraction between the ENDO and EPI cells. The modeling results predict that heterogeneity in the parameters of calcium handling and myofilament mechanics in isolated ENDO and EPI cardiomyocytes are essential to produce the differences in Ca2+ transients and contraction profiles via cooperative mechanisms of mechano-calcium-electric feedback and may further slightly modulate transmural differences in the electrical properties between the cells. Simulation results predict that ENDO cells have greater sensitivity to changes in the mechanical load than EPI cells. These data are important for understanding the behavior of cardiomyocytes in the intact heart.</description><subject>Action potential</subject><subject>Action Potentials - physiology</subject><subject>Analysis</subject><subject>Animal models</subject><subject>Animals</subject><subject>Biomechanical Phenomena - physiology</subject><subject>Calcium</subject><subject>Calcium - metabolism</subject><subject>Cardiac modeling</subject><subject>Cardiac transmural heterogeneity</subject><subject>Cardiology</subject><subject>Cardiomyocyte</subject><subject>Cardiomyocytes</subject><subject>Contraction</subject><subject>Electric properties</subject><subject>Electrical properties</subject><subject>Electromechanical coupling</subject><subject>Guinea Pigs</subject><subject>Heart</subject><subject>Mechanical properties</subject><subject>Mechano-calcium-electric feedback</subject><subject>Models, Cardiovascular</subject><subject>Myocardial Contraction - physiology</subject><subject>Myocardium - metabolism</subject><subject>Myocytes, Cardiac - physiology</subject><subject>Original Paper</subject><subject>Ventricle</subject><issn>1880-6546</issn><issn>1880-6562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UstuFDEQHCEQCYEP4IJW4sJlgnvGT3GAKOIlReISzpbXbu86mrGDPRNp_x4PGxaCVsgHW3ZVdXe5muYlkHMgRLwt0DHBWwKiJYxCSx41pyAlaTnj3ePDmfKT5lkpN4RQrjr5tDnpJBM9U_S0-XCdTSzjnM2wsjgM82DyaosT5rTBiGHarUJcjbtkTXahgnBAO-U0ot2aGGx53jzxZij44n4_a75_-nh9-aW9-vb56-XFVWs5UVPrqLC96JEZ6r0Ar4ALt1auVxTXXjLDvFBKKkqdcxx6xawE6R1H40nPRX_WvN_r3s7rEZ3FONWe9W0Oo8k7nUzQD19i2OpNutNABAggrCq8uVfI6ceMZdJjKMvMJmKaiwZFqivVoaXY63-gN2nOsc6nO0IVAFUC_qA2ZkAdok-1sF1E9YXgrO-4_NV4ewS1mFu7TBF9qNcP8OdH8HU5HIM9SoA9weZUSkZ_MAWIXnKi9znRNSd6yYkmlfPqbzcPjN_BqIB3ewDWP70LmHWxAaNFF3INgHYp_Ef-J31Uyug</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Khokhlova, Anastasia</creator><creator>Balakina-Vikulova, Nathalie</creator><creator>Katsnelson, Leonid</creator><creator>Iribe, Gentaro</creator><creator>Solovyova, Olga</creator><general>Elsevier Inc</general><general>Springer</general><general>BioMed Central</general><general>Springer Japan</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2966-8437</orcidid></search><sort><creationdate>20180701</creationdate><title>Transmural cellular heterogeneity in myocardial electromechanics</title><author>Khokhlova, Anastasia ; Balakina-Vikulova, Nathalie ; Katsnelson, Leonid ; Iribe, Gentaro ; Solovyova, Olga</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c609t-d47c373e5a4ff71f9167db9d394ebf85a5f7998944ddd61395c818fd6eaf03673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Action potential</topic><topic>Action Potentials - physiology</topic><topic>Analysis</topic><topic>Animal models</topic><topic>Animals</topic><topic>Biomechanical Phenomena - physiology</topic><topic>Calcium</topic><topic>Calcium - metabolism</topic><topic>Cardiac modeling</topic><topic>Cardiac transmural heterogeneity</topic><topic>Cardiology</topic><topic>Cardiomyocyte</topic><topic>Cardiomyocytes</topic><topic>Contraction</topic><topic>Electric properties</topic><topic>Electrical properties</topic><topic>Electromechanical coupling</topic><topic>Guinea Pigs</topic><topic>Heart</topic><topic>Mechanical properties</topic><topic>Mechano-calcium-electric feedback</topic><topic>Models, Cardiovascular</topic><topic>Myocardial Contraction - physiology</topic><topic>Myocardium - metabolism</topic><topic>Myocytes, Cardiac - physiology</topic><topic>Original Paper</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khokhlova, Anastasia</creatorcontrib><creatorcontrib>Balakina-Vikulova, Nathalie</creatorcontrib><creatorcontrib>Katsnelson, Leonid</creatorcontrib><creatorcontrib>Iribe, Gentaro</creatorcontrib><creatorcontrib>Solovyova, Olga</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of physiological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khokhlova, Anastasia</au><au>Balakina-Vikulova, Nathalie</au><au>Katsnelson, Leonid</au><au>Iribe, Gentaro</au><au>Solovyova, Olga</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transmural cellular heterogeneity in myocardial electromechanics</atitle><jtitle>The journal of physiological sciences</jtitle><addtitle>J Physiol Sci</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>68</volume><issue>4</issue><spage>387</spage><epage>413</epage><pages>387-413</pages><issn>1880-6546</issn><eissn>1880-6562</eissn><abstract>Myocardial heterogeneity is an attribute of the normal heart. We have developed integrative models of cardiomyocytes from the subendocardial (ENDO) and subepicardial (EPI) ventricular regions that take into account experimental data on specific regional features of intracellular electromechanical coupling in the guinea pig heart. The models adequately simulate experimental data on the differences in the action potential and contraction between the ENDO and EPI cells. The modeling results predict that heterogeneity in the parameters of calcium handling and myofilament mechanics in isolated ENDO and EPI cardiomyocytes are essential to produce the differences in Ca2+ transients and contraction profiles via cooperative mechanisms of mechano-calcium-electric feedback and may further slightly modulate transmural differences in the electrical properties between the cells. Simulation results predict that ENDO cells have greater sensitivity to changes in the mechanical load than EPI cells. 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| subjects | Action potential Action Potentials - physiology Analysis Animal models Animals Biomechanical Phenomena - physiology Calcium Calcium - metabolism Cardiac modeling Cardiac transmural heterogeneity Cardiology Cardiomyocyte Cardiomyocytes Contraction Electric properties Electrical properties Electromechanical coupling Guinea Pigs Heart Mechanical properties Mechano-calcium-electric feedback Models, Cardiovascular Myocardial Contraction - physiology Myocardium - metabolism Myocytes, Cardiac - physiology Original Paper Ventricle |
| title | Transmural cellular heterogeneity in myocardial electromechanics |
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