Anti-arrhythmic effect of diosgenin in reperfusion-induced myocardial injury in a rat model: activation of nitric oxide system and mitochondrial KATP channel

This study was designed to investigate the anti-arrhythmic effect of diosgenin preconditioning in myocardial reperfusion injury in rat, focusing on the involvement of the nitric oxide (NO) system and mitochondrial ATP-dependent potassium (mitoKATP) channels in this scenario. After isolation of the h...

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Veröffentlicht in:	The journal of physiological sciences 2014-11, Vol.64 (6), p.393-400
Hauptverfasser:	Badalzadeh, Reza, Yousefi, Bahman, Majidinia, Maryam, Ebrahimi, Hadi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Arrhythmia Agents - pharmacology Arrhythmias, Cardiac - drug therapy Arrhythmias, Cardiac - metabolism Cardiotonic Agents - pharmacology Decanoic Acids - pharmacology Diosgenin - pharmacology Heart - drug effects Hydroxy Acids - pharmacology L-Lactate Dehydrogenase - metabolism Male Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - metabolism NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - metabolism Original Paper Potassium Channels - metabolism Rats Rats, Wistar Tachycardia, Ventricular - drug therapy Tachycardia, Ventricular - metabolism Ventricular Fibrillation - drug therapy Ventricular Fibrillation - metabolism
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