Distributions of different types of nociceptive neurons in thalamic mediodorsal nuclei of anesthetized rats
Mediodorsal thalamic nucleus (MD) is a critical relay of nociception. This study recorded responses of MD neurons to noxious mechanical and thermal stimuli in isoflurane anesthetized rats. We found the threshold of noxious mechanical stimulation was 141 gw and that of noxious heat stimulation was 46...
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| Veröffentlicht in: | The journal of physiological sciences 2019-03, Vol.69 (2), p.387-397 |
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| description | Mediodorsal thalamic nucleus (MD) is a critical relay of nociception. This study recorded responses of MD neurons to noxious mechanical and thermal stimuli in isoflurane anesthetized rats. We found the threshold of noxious mechanical stimulation was 141 gw and that of noxious heat stimulation was 46 °C. A significantly higher percentage of noxious inhibitory neurons were found in the medial and central part of the MD, whereas a higher percentage of noxious excitatory neurons were found in the lateral part of the MD and adjacent intralaminar nuclei. The differential distribution of excitatory and inhibitory neurons implies functional differentiation between the medial and lateral part of the MD in nociception processing. Furthermore, by an analysis of the stimulus-response function (SRF), we found 80% of these excitatory neurons had a step-function or hat-shape-like SRF. This suggests that most of the MD neurons may serve as a system to distinguish innocuous versus noxious stimuli. |
| doi_str_mv | 10.1007/s12576-018-00656-3 |
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This study recorded responses of MD neurons to noxious mechanical and thermal stimuli in isoflurane anesthetized rats. We found the threshold of noxious mechanical stimulation was 141 gw and that of noxious heat stimulation was 46 °C. A significantly higher percentage of noxious inhibitory neurons were found in the medial and central part of the MD, whereas a higher percentage of noxious excitatory neurons were found in the lateral part of the MD and adjacent intralaminar nuclei. The differential distribution of excitatory and inhibitory neurons implies functional differentiation between the medial and lateral part of the MD in nociception processing. Furthermore, by an analysis of the stimulus-response function (SRF), we found 80% of these excitatory neurons had a step-function or hat-shape-like SRF. This suggests that most of the MD neurons may serve as a system to distinguish innocuous versus noxious stimuli.</description><identifier>ISSN: 1880-6546</identifier><identifier>EISSN: 1880-6562</identifier><identifier>DOI: 10.1007/s12576-018-00656-3</identifier><identifier>PMID: 30604289</identifier><language>eng</language><publisher>Japan: Springer</publisher><subject>Anesthesia ; Animals ; Blood pressure ; Electrodes ; Experiments ; Heart rate ; Heat ; Isoflurane ; Laboratory animals ; Male ; Mechanical stimuli ; Mediodorsal Thalamic Nucleus - physiology ; Neurons ; Neurons - physiology ; Nociception - physiology ; Nociceptors - physiology ; Original Paper ; Pain perception ; Rats ; Rats, Wistar ; Rodents ; Skin ; Thalamus ; Thermal stimuli</subject><ispartof>The journal of physiological sciences, 2019-03, Vol.69 (2), p.387-397</ispartof><rights>COPYRIGHT 2019 Springer</rights><rights>Copyright Springer Nature B.V. 2019</rights><rights>2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</rights><rights>The Physiological Society of Japan and Springer Japan KK, part of Springer Nature 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c587t-7641bc2faca52f00e6125665389014bb3081cfc8320e3f755365c82f478e1253</citedby><cites>FETCH-LOGICAL-c587t-7641bc2faca52f00e6125665389014bb3081cfc8320e3f755365c82f478e1253</cites><orcidid>0000-0002-0076-4487</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10716950/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10716950/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30604289$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Pen-Li</creatorcontrib><creatorcontrib>Tsai, Meng-Li</creatorcontrib><creatorcontrib>Jaw, Fu-Shan</creatorcontrib><creatorcontrib>Yen, Chen-Tung</creatorcontrib><title>Distributions of different types of nociceptive neurons in thalamic mediodorsal nuclei of anesthetized rats</title><title>The journal of physiological sciences</title><addtitle>J Physiol Sci</addtitle><description>Mediodorsal thalamic nucleus (MD) is a critical relay of nociception. This study recorded responses of MD neurons to noxious mechanical and thermal stimuli in isoflurane anesthetized rats. We found the threshold of noxious mechanical stimulation was 141 gw and that of noxious heat stimulation was 46 °C. A significantly higher percentage of noxious inhibitory neurons were found in the medial and central part of the MD, whereas a higher percentage of noxious excitatory neurons were found in the lateral part of the MD and adjacent intralaminar nuclei. The differential distribution of excitatory and inhibitory neurons implies functional differentiation between the medial and lateral part of the MD in nociception processing. Furthermore, by an analysis of the stimulus-response function (SRF), we found 80% of these excitatory neurons had a step-function or hat-shape-like SRF. This suggests that most of the MD neurons may serve as a system to distinguish innocuous versus noxious stimuli.</description><subject>Anesthesia</subject><subject>Animals</subject><subject>Blood pressure</subject><subject>Electrodes</subject><subject>Experiments</subject><subject>Heart rate</subject><subject>Heat</subject><subject>Isoflurane</subject><subject>Laboratory animals</subject><subject>Male</subject><subject>Mechanical stimuli</subject><subject>Mediodorsal Thalamic Nucleus - physiology</subject><subject>Neurons</subject><subject>Neurons - physiology</subject><subject>Nociception - physiology</subject><subject>Nociceptors - physiology</subject><subject>Original Paper</subject><subject>Pain perception</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Skin</subject><subject>Thalamus</subject><subject>Thermal stimuli</subject><issn>1880-6546</issn><issn>1880-6562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kk1v1DAQhiMEoqXwBzigSFy4pIzt-CMnVJVPqRKX3i2vd7zrkrUXO6nU_npmd8sKUIVySOw872jembdpXjM4ZwD6fWVcatUBMx2AkqoTT5pTZgx0dOBPj9-9Omle1HoD0KuBm-fNiQAFPTfDafPjY6xTiYt5ijnVNod2GUPAgmlqp7st7q9S9tHjdoq32Cacy46MqZ3WbnSb6NsNLmNe5lLd2KbZjxh3KpewTmuc4j0u2-Km-rJ5FtxY8dXD-6y5_vzp-vJrd_X9y7fLi6vOS6OnTqueLTwPzjvJAwAq8qmUFGYA1i8WAgzzwRvBAUXQUgolveGh1waJFGfNh0PZ7bygzjxZKW602xI3rtzZ7KL9-0-Ka7vKt5aBZmqQQBXePVQo-edMLuwmVo_jSJbyXC1nSgAMPdeEvv0HvclzSWTP0nJkD0z0_L8U04MeQO-p7kCt3Ig2ppCpPb_ChNRlThgiXV9omgStTjLizx_h6VkibeVRAT8IfMm1FgzHoTCwu0jZQ6QsRcruI2UFid78Oc6j5HeGxC-aE8bH</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Lu, Pen-Li</creator><creator>Tsai, Meng-Li</creator><creator>Jaw, Fu-Shan</creator><creator>Yen, Chen-Tung</creator><general>Springer</general><general>BioMed Central</general><general>Springer Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0076-4487</orcidid></search><sort><creationdate>20190301</creationdate><title>Distributions of different types of nociceptive neurons in thalamic mediodorsal nuclei of anesthetized rats</title><author>Lu, Pen-Li ; Tsai, Meng-Li ; Jaw, Fu-Shan ; Yen, Chen-Tung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c587t-7641bc2faca52f00e6125665389014bb3081cfc8320e3f755365c82f478e1253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anesthesia</topic><topic>Animals</topic><topic>Blood pressure</topic><topic>Electrodes</topic><topic>Experiments</topic><topic>Heart rate</topic><topic>Heat</topic><topic>Isoflurane</topic><topic>Laboratory animals</topic><topic>Male</topic><topic>Mechanical stimuli</topic><topic>Mediodorsal Thalamic Nucleus - physiology</topic><topic>Neurons</topic><topic>Neurons - physiology</topic><topic>Nociception - physiology</topic><topic>Nociceptors - physiology</topic><topic>Original Paper</topic><topic>Pain perception</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Skin</topic><topic>Thalamus</topic><topic>Thermal stimuli</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Pen-Li</creatorcontrib><creatorcontrib>Tsai, Meng-Li</creatorcontrib><creatorcontrib>Jaw, Fu-Shan</creatorcontrib><creatorcontrib>Yen, Chen-Tung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of physiological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Pen-Li</au><au>Tsai, Meng-Li</au><au>Jaw, Fu-Shan</au><au>Yen, Chen-Tung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distributions of different types of nociceptive neurons in thalamic mediodorsal nuclei of anesthetized rats</atitle><jtitle>The journal of physiological sciences</jtitle><addtitle>J Physiol Sci</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>69</volume><issue>2</issue><spage>387</spage><epage>397</epage><pages>387-397</pages><issn>1880-6546</issn><eissn>1880-6562</eissn><abstract>Mediodorsal thalamic nucleus (MD) is a critical relay of nociception. This study recorded responses of MD neurons to noxious mechanical and thermal stimuli in isoflurane anesthetized rats. We found the threshold of noxious mechanical stimulation was 141 gw and that of noxious heat stimulation was 46 °C. A significantly higher percentage of noxious inhibitory neurons were found in the medial and central part of the MD, whereas a higher percentage of noxious excitatory neurons were found in the lateral part of the MD and adjacent intralaminar nuclei. The differential distribution of excitatory and inhibitory neurons implies functional differentiation between the medial and lateral part of the MD in nociception processing. Furthermore, by an analysis of the stimulus-response function (SRF), we found 80% of these excitatory neurons had a step-function or hat-shape-like SRF. This suggests that most of the MD neurons may serve as a system to distinguish innocuous versus noxious stimuli.</abstract><cop>Japan</cop><pub>Springer</pub><pmid>30604289</pmid><doi>10.1007/s12576-018-00656-3</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-0076-4487</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Anesthesia Animals Blood pressure Electrodes Experiments Heart rate Heat Isoflurane Laboratory animals Male Mechanical stimuli Mediodorsal Thalamic Nucleus - physiology Neurons Neurons - physiology Nociception - physiology Nociceptors - physiology Original Paper Pain perception Rats Rats, Wistar Rodents Skin Thalamus Thermal stimuli |
| title | Distributions of different types of nociceptive neurons in thalamic mediodorsal nuclei of anesthetized rats |
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