Kinome profiling identifies MARK3 and STK10 as potential therapeutic targets in uveal melanoma

Most uveal melanoma cases harbor activating mutations in either GNAQ or GNA11. Despite activation of the mitogen-activated protein kinase (MAPK) signaling pathway downstream of Gαq/11, there are no effective targeted kinase therapies for metastatic uveal melanoma. The human genome encodes numerous u...

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Veröffentlicht in:	The Journal of biological chemistry 2023-12, Vol.299 (12), p.105418-105418, Article 105418
Hauptverfasser:	Baqai, Usman, Kurimchak, Alison M., Trachtenberg, Isabella V., Purwin, Timothy J., Haj, Jelan I., Han, Anna, Luo, Kristine, Pachon, Nikole Fandino, Jeon, Angela, Chua, Vivian, Davies, Michael A., Gutkind, J. Silvio, Benovic, Jeffrey L., Duncan, James S., Aplin, Andrew E.
Format:	Artikel
Sprache:	eng
Schlagworte:	cancer Cell Line, Tumor g protein GTP-Binding Protein alpha Subunits, Gq-G11 - genetics GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism guanine nucleotide-binding protein G(q) subunit alpha Humans melanoma Melanoma - drug therapy Melanoma - enzymology Melanoma - genetics microtubule affinity-regulating kinase 3 mitogen-activated protein kinase (MAPK) Mutation Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Proteomics serine/threonine-protein kinase 10 Uveal Neoplasms - drug therapy Uveal Neoplasms - enzymology Uveal Neoplasms - genetics
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