DNA-methylation signature accurately differentiates pancreatic cancer from chronic pancreatitis in tissue and plasma

ObjectivePancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy. Differentiation from chronic pancreatitis (CP) is currently inaccurate in about one-third of cases. Misdiagnoses in both directions, however, have severe consequences for patients. We set out to identify molecular markers for a...

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Veröffentlicht in:	Gut 2023-12, Vol.72 (12), p.2344-2353
Hauptverfasser:	Wu, Yenan, Seufert, Isabelle, Al-Shaheri, Fawaz N, Kurilov, Roman, Bauer, Andrea S, Manoochehri, Mehdi, Moskalev, Evgeny A, Brors, Benedikt, Tjaden, Christin, Giese, Nathalia A, Hackert, Thilo, Büchler, Markus W, Hoheisel, Jörg D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Biomarkers Biomarkers, Tumor - genetics Biopsy Carcinoma, Pancreatic Ductal - diagnosis Carcinoma, Pancreatic Ductal - genetics chronic pancreatitis CpG islands Datasets DNA DNA Methylation Embedding Genomes Humans Learning algorithms Machine learning Malignancy MicroRNAs miRNA mRNA Pancreas Pancreatic cancer Pancreatic Neoplasms Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Pancreatitis Pancreatitis, Chronic - diagnosis Pancreatitis, Chronic - genetics Protein kinase C
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