Monoclonal Antibodies: What the Diagnostic Neuroradiologist Needs to Know
Monoclonal antibodies have become increasingly popular as novel therapeutics against a variety of diseases due to their specificity, affinity, and serum stability. Due to the nearly infinite repertoire of monoclonal antibodies, their therapeutic use is rapidly expanding, revolutionizing disease cour...
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| Veröffentlicht in: | American journal of neuroradiology : AJNR 2023-12, Vol.44 (12), p.1358-1366 |
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| container_title | American journal of neuroradiology : AJNR |
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| creator | Alsufayan, R Hess, C Krings, T |
| description | Monoclonal antibodies have become increasingly popular as novel therapeutics against a variety of diseases due to their specificity, affinity, and serum stability. Due to the nearly infinite repertoire of monoclonal antibodies, their therapeutic use is rapidly expanding, revolutionizing disease course and management, and what is now considered experimental therapy may soon become approved practice. Therefore, it is important for radiologists, neuroradiologists, and neurologists to be aware of these drugs and their possible different imaging-related manifestations, including expected and adverse effects of these novel drugs. Herein, we review the most commonly used monoclonal antibody-targeted therapeutic agents, their mechanism of action, clinical applications, and major adverse events with a focus on neurologic and neurographic effects and discuss differential considerations, to assist in the diagnosis of these conditions. |
| doi_str_mv | 10.3174/ajnr.A7974 |
| format | Article |
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| identifier | ISSN: 0195-6108 |
| ispartof | American journal of neuroradiology : AJNR, 2023-12, Vol.44 (12), p.1358-1366 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Brain Antibodies, Monoclonal - therapeutic use Antineoplastic Agents - therapeutic use Fellows' Journal Club Humans Radiologists |
| title | Monoclonal Antibodies: What the Diagnostic Neuroradiologist Needs to Know |
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