Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial

IMPORTANCE: The effect of continued treatment with tirzepatide on maintaining initial weight reduction is unknown. OBJECTIVE: To assess the effect of tirzepatide, with diet and physical activity, on the maintenance of weight reduction. DESIGN, SETTING, AND PARTICIPANTS: This phase 3, randomized with...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2024-01, Vol.331 (1), p.38-48
Hauptverfasser:	Aronne, Louis J, Sattar, Naveed, Horn, Deborah B, Bays, Harold E, Wharton, Sean, Lin, Wen-Yuan, Ahmad, Nadia N, Zhang, Shuyu, Liao, Ran, Bunck, Mathijs C, Jouravskaya, Irina, Murphy, Madhumita A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adults Anti-Obesity Agents - administration & dosage Anti-Obesity Agents - adverse effects Anti-Obesity Agents - pharmacology Anti-Obesity Agents - therapeutic use Antidiabetics Body mass Body mass index Body size Body weight loss Clinical trials Diabetes mellitus Double-Blind Method Female Gastric Inhibitory Polypeptide - administration & dosage Gastric Inhibitory Polypeptide - adverse effects Gastric Inhibitory Polypeptide - pharmacology Gastric Inhibitory Polypeptide - therapeutic use Glucagon-Like Peptide-2 Receptor - administration & dosage Glucagon-Like Peptide-2 Receptor - agonists Glucagon-Like Peptide-2 Receptor - therapeutic use Humans Incretins - administration & dosage Incretins - adverse effects Incretins - pharmacology Incretins - therapeutic use Injections, Subcutaneous Labels Maintenance Maintenance Chemotherapy Male Middle Aged Obesity Obesity - complications Obesity - drug therapy Online First Original Investigation Overweight - complications Overweight - drug therapy Physical activity Placebos Randomization Treatment Outcome Weight control Weight loss Weight Loss - drug effects Weight reduction Withholding Treatment
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