Genome mining of actinomycin shunt products from Kitasatospora sp. YINM00002
Actinomycins are known for their anti-tumor, antibacterial and antiviral activities, and in particular for the ability of actinomycin D as a clinical drug to treat a variety of cancers. In our ongoing work to obtain novel natural products from endophytic actinomycetes derived from traditional Chines...
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| Veröffentlicht in: | RSC advances 2023-12, Vol.13 (51), p.36200-36208 |
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| creator | Zhang, Zhou-Tian-Le Sun, Hui-Bing Ren, Zhen Xie, Tian-Peng Wang, Ying-Fang Guo, Yin Su, Xiaoyu Yin, Min Zhou, Hao Ding, Zhong-Tao |
| description | Actinomycins are known for their anti-tumor, antibacterial and antiviral activities, and in particular for the ability of actinomycin D as a clinical drug to treat a variety of cancers. In our ongoing work to obtain novel natural products from endophytic actinomycetes derived from traditional Chinese herbs, we identified the potential to produce actinomycins in YINM00002, a
strain derived from
. According to genome mining, we isolated actinomycins D and V (1 and 2) and small amounts of 4-methyl-3-hydroxyanthranilic acid (4-MHA) derivates (3 and 4) from strain fermentation broth. The presence of actinrhater A (3) and actinrhater B (4) reveals a mysterious shunt pathway in the early stages of actinomycin D biosynthesis. Our study provides a fresh perspective for further discovery and modification of novel actinomycins. |
| doi_str_mv | 10.1039/d3ra07277k |
| format | Article |
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strain derived from
. According to genome mining, we isolated actinomycins D and V (1 and 2) and small amounts of 4-methyl-3-hydroxyanthranilic acid (4-MHA) derivates (3 and 4) from strain fermentation broth. The presence of actinrhater A (3) and actinrhater B (4) reveals a mysterious shunt pathway in the early stages of actinomycin D biosynthesis. Our study provides a fresh perspective for further discovery and modification of novel actinomycins.</description><identifier>ISSN: 2046-2069</identifier><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/d3ra07277k</identifier><identifier>PMID: 38090065</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Actinomycetes ; Actinomycin ; Anticancer properties ; Biosynthesis ; Chemistry ; Natural products</subject><ispartof>RSC advances, 2023-12, Vol.13 (51), p.36200-36208</ispartof><rights>This journal is © The Royal Society of Chemistry.</rights><rights>Copyright Royal Society of Chemistry 2023</rights><rights>This journal is © The Royal Society of Chemistry 2023 The Royal Society of Chemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-adfb11d7d433b753b942c19c95fddd31831514c4a6959579580d3ee4c81a448b3</citedby><cites>FETCH-LOGICAL-c407t-adfb11d7d433b753b942c19c95fddd31831514c4a6959579580d3ee4c81a448b3</cites><orcidid>0000-0002-9256-6022 ; 0000-0002-7860-060X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10714260/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10714260/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38090065$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Zhou-Tian-Le</creatorcontrib><creatorcontrib>Sun, Hui-Bing</creatorcontrib><creatorcontrib>Ren, Zhen</creatorcontrib><creatorcontrib>Xie, Tian-Peng</creatorcontrib><creatorcontrib>Wang, Ying-Fang</creatorcontrib><creatorcontrib>Guo, Yin</creatorcontrib><creatorcontrib>Su, Xiaoyu</creatorcontrib><creatorcontrib>Yin, Min</creatorcontrib><creatorcontrib>Zhou, Hao</creatorcontrib><creatorcontrib>Ding, Zhong-Tao</creatorcontrib><title>Genome mining of actinomycin shunt products from Kitasatospora sp. YINM00002</title><title>RSC advances</title><addtitle>RSC Adv</addtitle><description>Actinomycins are known for their anti-tumor, antibacterial and antiviral activities, and in particular for the ability of actinomycin D as a clinical drug to treat a variety of cancers. In our ongoing work to obtain novel natural products from endophytic actinomycetes derived from traditional Chinese herbs, we identified the potential to produce actinomycins in YINM00002, a
strain derived from
. According to genome mining, we isolated actinomycins D and V (1 and 2) and small amounts of 4-methyl-3-hydroxyanthranilic acid (4-MHA) derivates (3 and 4) from strain fermentation broth. The presence of actinrhater A (3) and actinrhater B (4) reveals a mysterious shunt pathway in the early stages of actinomycin D biosynthesis. Our study provides a fresh perspective for further discovery and modification of novel actinomycins.</description><subject>Actinomycetes</subject><subject>Actinomycin</subject><subject>Anticancer properties</subject><subject>Biosynthesis</subject><subject>Chemistry</subject><subject>Natural products</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkctKxDAUhoMojqgbH0ACbkQYza1NsxIZr8yoILpwFdIkHaPTpCat4NvbehnUszm3j59z-AHYwegQIyqODI0KccL5ywrYIIjlY4JysfqrHoHtlJ5RH3mGSY7XwYgWSAztBphdWB9qC2vnnZ_DUEGlW9eP3rXzMD11voVNDKbTbYJVDDWculYl1YbUhKhgag7h49XN9SBPtsBapRbJbn_nTfBwfnY_uRzPbi-uJiezsWaIt2NlqhJjww2jtOQZLQUjGgstssoYQ3FBcYaZZioXmci4yApkqLVMF1gxVpR0Exx_6TZdWVujrW-jWsgmulrFdxmUk3833j3JeXiTGHHMSI56hf1vhRheO5taWbuk7WKhvA1dkkQgIvKMkQHd-4c-hy76_r-BokTQnOOeOviidAwpRVstr8FIDkbJU3p38mnUtId3f9-_RH9soR_FKYxt</recordid><startdate>20231208</startdate><enddate>20231208</enddate><creator>Zhang, Zhou-Tian-Le</creator><creator>Sun, Hui-Bing</creator><creator>Ren, Zhen</creator><creator>Xie, Tian-Peng</creator><creator>Wang, Ying-Fang</creator><creator>Guo, Yin</creator><creator>Su, Xiaoyu</creator><creator>Yin, Min</creator><creator>Zhou, Hao</creator><creator>Ding, Zhong-Tao</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9256-6022</orcidid><orcidid>https://orcid.org/0000-0002-7860-060X</orcidid></search><sort><creationdate>20231208</creationdate><title>Genome mining of actinomycin shunt products from Kitasatospora sp. YINM00002</title><author>Zhang, Zhou-Tian-Le ; Sun, Hui-Bing ; Ren, Zhen ; Xie, Tian-Peng ; Wang, Ying-Fang ; Guo, Yin ; Su, Xiaoyu ; Yin, Min ; Zhou, Hao ; Ding, Zhong-Tao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-adfb11d7d433b753b942c19c95fddd31831514c4a6959579580d3ee4c81a448b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Actinomycetes</topic><topic>Actinomycin</topic><topic>Anticancer properties</topic><topic>Biosynthesis</topic><topic>Chemistry</topic><topic>Natural products</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Zhou-Tian-Le</creatorcontrib><creatorcontrib>Sun, Hui-Bing</creatorcontrib><creatorcontrib>Ren, Zhen</creatorcontrib><creatorcontrib>Xie, Tian-Peng</creatorcontrib><creatorcontrib>Wang, Ying-Fang</creatorcontrib><creatorcontrib>Guo, Yin</creatorcontrib><creatorcontrib>Su, Xiaoyu</creatorcontrib><creatorcontrib>Yin, Min</creatorcontrib><creatorcontrib>Zhou, Hao</creatorcontrib><creatorcontrib>Ding, Zhong-Tao</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Zhou-Tian-Le</au><au>Sun, Hui-Bing</au><au>Ren, Zhen</au><au>Xie, Tian-Peng</au><au>Wang, Ying-Fang</au><au>Guo, Yin</au><au>Su, Xiaoyu</au><au>Yin, Min</au><au>Zhou, Hao</au><au>Ding, Zhong-Tao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genome mining of actinomycin shunt products from Kitasatospora sp. YINM00002</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2023-12-08</date><risdate>2023</risdate><volume>13</volume><issue>51</issue><spage>36200</spage><epage>36208</epage><pages>36200-36208</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>Actinomycins are known for their anti-tumor, antibacterial and antiviral activities, and in particular for the ability of actinomycin D as a clinical drug to treat a variety of cancers. In our ongoing work to obtain novel natural products from endophytic actinomycetes derived from traditional Chinese herbs, we identified the potential to produce actinomycins in YINM00002, a
strain derived from
. According to genome mining, we isolated actinomycins D and V (1 and 2) and small amounts of 4-methyl-3-hydroxyanthranilic acid (4-MHA) derivates (3 and 4) from strain fermentation broth. The presence of actinrhater A (3) and actinrhater B (4) reveals a mysterious shunt pathway in the early stages of actinomycin D biosynthesis. Our study provides a fresh perspective for further discovery and modification of novel actinomycins.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>38090065</pmid><doi>10.1039/d3ra07277k</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9256-6022</orcidid><orcidid>https://orcid.org/0000-0002-7860-060X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Actinomycetes Actinomycin Anticancer properties Biosynthesis Chemistry Natural products |
| title | Genome mining of actinomycin shunt products from Kitasatospora sp. YINM00002 |
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