Dual RNase activity of IRE1 as a target for anticancer therapies

The unfolded protein response (UPR) is a cellular mechanism that protects cells during stress conditions in which there is an accumulation of misfolded proteins in the endoplasmic reticulum (ER). UPR activates three signaling pathways that function to alleviate stress conditions and promote cellular...

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Veröffentlicht in:	Journal of cell communication and signaling 2023-12, Vol.17 (4), p.1145-1161
Hauptverfasser:	Bartoszewska, Sylwia, Sławski, Jakub, Collawn, James F., Bartoszewski, Rafał
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Basal RIDD Biomedical and Life Sciences Biomedicine Cancer Cancer therapies Cell Biology Cell death Cell fate Cell survival Cellular stress response Endoplasmic reticulum ER‐stress Homeostasis Inositol IRE1α Life Sciences Protein folding Review RIDD Signal transduction UPR XBP1
Online-Zugang:	Volltext
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