The Atrial Natriuretic Peptide-to-brain Natriuretic Peptide Ratio Predicts Left Atrial Reverse Remodeling after Rhythm Control Therapy in Patients with Persistent Atrial Fibrillation
Objective The association between natriuretic peptide levels in atrial fibrillation (AF) patients with advanced left atrial (LA) remodeling and reverse remodeling after rhythm control therapy has not been clarified. The present study assessed the role of atrial natriuretic peptide (ANP) and brain na...
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| Veröffentlicht in: | Internal Medicine 2023/11/15, Vol.62(22), pp.3283-3290 |
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| creator | Hasegawa, Yuki Okada, Shinsuke Sanada, Akiko Tomii, Asako Sugiura, Hirotaka Higuchi, Kotaro Chinushi, Masaomi Inomata, Takayuki |
| description | Objective The association between natriuretic peptide levels in atrial fibrillation (AF) patients with advanced left atrial (LA) remodeling and reverse remodeling after rhythm control therapy has not been clarified. The present study assessed the role of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) measurements to predict LA reverse remodeling after catheter ablation (CA) in persistent AF patients with LA enlargement. Methods This study included 88 persistent AF patients with LA enlargement (volume index >48 mL/m2) who underwent CA. Plasma ANP and BNP levels were analyzed before CA in all patients. The study population was divided into 2 groups according to the extent of decrease in the LA volume index (LAVI) at 6 months after CA responders were those with a ≥15% reduction in the LAVI, and all others were non-responders. Results At follow-up, 58 patients (66%) were classified as responders. The preprocedural ANP level was significantly higher in the responders than in the non-responders (p=0.03). Furthermore, the ANP-to-BNP ratio (ANP/BNP) was significantly higher in the responders than in the non-responders (p |
| doi_str_mv | 10.2169/internalmedicine.1478-22 |
| format | Article |
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The present study assessed the role of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) measurements to predict LA reverse remodeling after catheter ablation (CA) in persistent AF patients with LA enlargement. Methods This study included 88 persistent AF patients with LA enlargement (volume index >48 mL/m2) who underwent CA. Plasma ANP and BNP levels were analyzed before CA in all patients. The study population was divided into 2 groups according to the extent of decrease in the LA volume index (LAVI) at 6 months after CA responders were those with a ≥15% reduction in the LAVI, and all others were non-responders. Results At follow-up, 58 patients (66%) were classified as responders. The preprocedural ANP level was significantly higher in the responders than in the non-responders (p=0.03). Furthermore, the ANP-to-BNP ratio (ANP/BNP) was significantly higher in the responders than in the non-responders (p<0.01). The ANP/BNP was correlated with the percentage decrease in the LAVI (r=0.391, p<0.01). A multivariate linear regression analysis revealed that the ANP/BNP before CA was an independent predictor of LA reverse remodeling (p<0.01). Conclusion The preprocedural ANP/BNP was a robust predictor of reverse remodeling of the enlarged LA after sinus rhythm restoration by rhythm control therapy in persistent AF patients.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.1478-22</identifier><identifier>PMID: 36823080</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Atrial Fibrillation ; Atrial Natriuretic Factor ; Atrial natriuretic peptide ; Brain natriuretic peptide ; Cardiac arrhythmia ; catheter ablation ; Enlargement ; Fibrillation ; Humans ; Internal medicine ; Linear Models ; Multivariate Analysis ; Natriuretic Peptide, Brain ; Original ; Peptides ; Population studies ; reverse remodeling</subject><ispartof>Internal Medicine, 2023/11/15, Vol.62(22), pp.3283-3290</ispartof><rights>2023 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2023</rights><rights>Copyright © 2023 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c587t-c1f400310b599533321b310dd2638c860557ab5e6cd81390a31610690cb6f8853</citedby><cites>FETCH-LOGICAL-c587t-c1f400310b599533321b310dd2638c860557ab5e6cd81390a31610690cb6f8853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10713385/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10713385/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1876,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36823080$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hasegawa, Yuki</creatorcontrib><creatorcontrib>Okada, Shinsuke</creatorcontrib><creatorcontrib>Sanada, Akiko</creatorcontrib><creatorcontrib>Tomii, Asako</creatorcontrib><creatorcontrib>Sugiura, Hirotaka</creatorcontrib><creatorcontrib>Higuchi, Kotaro</creatorcontrib><creatorcontrib>Chinushi, Masaomi</creatorcontrib><creatorcontrib>Inomata, Takayuki</creatorcontrib><title>The Atrial Natriuretic Peptide-to-brain Natriuretic Peptide Ratio Predicts Left Atrial Reverse Remodeling after Rhythm Control Therapy in Patients with Persistent Atrial Fibrillation</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>Objective The association between natriuretic peptide levels in atrial fibrillation (AF) patients with advanced left atrial (LA) remodeling and reverse remodeling after rhythm control therapy has not been clarified. The present study assessed the role of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) measurements to predict LA reverse remodeling after catheter ablation (CA) in persistent AF patients with LA enlargement. Methods This study included 88 persistent AF patients with LA enlargement (volume index >48 mL/m2) who underwent CA. Plasma ANP and BNP levels were analyzed before CA in all patients. The study population was divided into 2 groups according to the extent of decrease in the LA volume index (LAVI) at 6 months after CA responders were those with a ≥15% reduction in the LAVI, and all others were non-responders. Results At follow-up, 58 patients (66%) were classified as responders. The preprocedural ANP level was significantly higher in the responders than in the non-responders (p=0.03). Furthermore, the ANP-to-BNP ratio (ANP/BNP) was significantly higher in the responders than in the non-responders (p<0.01). The ANP/BNP was correlated with the percentage decrease in the LAVI (r=0.391, p<0.01). A multivariate linear regression analysis revealed that the ANP/BNP before CA was an independent predictor of LA reverse remodeling (p<0.01). Conclusion The preprocedural ANP/BNP was a robust predictor of reverse remodeling of the enlarged LA after sinus rhythm restoration by rhythm control therapy in persistent AF patients.</description><subject>Atrial Fibrillation</subject><subject>Atrial Natriuretic Factor</subject><subject>Atrial natriuretic peptide</subject><subject>Brain natriuretic peptide</subject><subject>Cardiac arrhythmia</subject><subject>catheter ablation</subject><subject>Enlargement</subject><subject>Fibrillation</subject><subject>Humans</subject><subject>Internal medicine</subject><subject>Linear Models</subject><subject>Multivariate Analysis</subject><subject>Natriuretic Peptide, Brain</subject><subject>Original</subject><subject>Peptides</subject><subject>Population studies</subject><subject>reverse remodeling</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkttuEzEQhlcIRNPCKyBL3HCzxYfsrn2FqqilSBGNonJteb2zWUebdbCdorwYz8csOQgKNx7Z_v39M57JMsLoNWel-uiGBGEw_QYaZ90A12xayZzzF9mEianKKy6Kl9mEKoanuFxklzGuKRWyUvx1diFKyQWVdJL9fOyA3KTgTE--Goy7AMlZsoBtcg3kyed1MG743yVZmuQ8WYQxixTJHNp0Yi3hCUJECWx8A70bVsS0mDRZdvvUbcjMDyn4nqB9MNs9QYcF0mBAzg-XOvQI0cWEByfknauD6_vRc3iTvWpNH-HtMV5l3-5uH2f3-fzh85fZzTy3haxSblk7xaoZrQulCiEEZzXumoaXQlpZ0qKoTF1AaRvJhKJGsJLRUlFbl62UhbjKPh24212Nn20xnWB6vQ1uY8Jee-P03zeD6_TKP2lGKybEb8KHIyH47zuISW9ctIB1DOB3UfNKUlrJalqi9P0z6drvxjajSlGmqkKJESgPKht8jAHaczaM6nE69PPp0ON0aM7x6bs_qzk_PI0DCh4OgnVMZgVngQnY9h7-JZccueN6tDgrbWeChkH8AitP3B8</recordid><startdate>20231115</startdate><enddate>20231115</enddate><creator>Hasegawa, Yuki</creator><creator>Okada, Shinsuke</creator><creator>Sanada, Akiko</creator><creator>Tomii, Asako</creator><creator>Sugiura, Hirotaka</creator><creator>Higuchi, Kotaro</creator><creator>Chinushi, Masaomi</creator><creator>Inomata, Takayuki</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20231115</creationdate><title>The Atrial Natriuretic Peptide-to-brain Natriuretic Peptide Ratio Predicts Left Atrial Reverse Remodeling after Rhythm Control Therapy in Patients with Persistent Atrial Fibrillation</title><author>Hasegawa, Yuki ; Okada, Shinsuke ; Sanada, Akiko ; Tomii, Asako ; Sugiura, Hirotaka ; Higuchi, Kotaro ; Chinushi, Masaomi ; Inomata, Takayuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c587t-c1f400310b599533321b310dd2638c860557ab5e6cd81390a31610690cb6f8853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Atrial Fibrillation</topic><topic>Atrial Natriuretic Factor</topic><topic>Atrial natriuretic peptide</topic><topic>Brain natriuretic peptide</topic><topic>Cardiac arrhythmia</topic><topic>catheter ablation</topic><topic>Enlargement</topic><topic>Fibrillation</topic><topic>Humans</topic><topic>Internal medicine</topic><topic>Linear Models</topic><topic>Multivariate Analysis</topic><topic>Natriuretic Peptide, Brain</topic><topic>Original</topic><topic>Peptides</topic><topic>Population studies</topic><topic>reverse remodeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hasegawa, Yuki</creatorcontrib><creatorcontrib>Okada, Shinsuke</creatorcontrib><creatorcontrib>Sanada, Akiko</creatorcontrib><creatorcontrib>Tomii, Asako</creatorcontrib><creatorcontrib>Sugiura, Hirotaka</creatorcontrib><creatorcontrib>Higuchi, Kotaro</creatorcontrib><creatorcontrib>Chinushi, Masaomi</creatorcontrib><creatorcontrib>Inomata, Takayuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hasegawa, Yuki</au><au>Okada, Shinsuke</au><au>Sanada, Akiko</au><au>Tomii, Asako</au><au>Sugiura, Hirotaka</au><au>Higuchi, Kotaro</au><au>Chinushi, Masaomi</au><au>Inomata, Takayuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Atrial Natriuretic Peptide-to-brain Natriuretic Peptide Ratio Predicts Left Atrial Reverse Remodeling after Rhythm Control Therapy in Patients with Persistent Atrial Fibrillation</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2023-11-15</date><risdate>2023</risdate><volume>62</volume><issue>22</issue><spage>3283</spage><epage>3290</epage><pages>3283-3290</pages><artnum>1478-22</artnum><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>Objective The association between natriuretic peptide levels in atrial fibrillation (AF) patients with advanced left atrial (LA) remodeling and reverse remodeling after rhythm control therapy has not been clarified. The present study assessed the role of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) measurements to predict LA reverse remodeling after catheter ablation (CA) in persistent AF patients with LA enlargement. Methods This study included 88 persistent AF patients with LA enlargement (volume index >48 mL/m2) who underwent CA. Plasma ANP and BNP levels were analyzed before CA in all patients. The study population was divided into 2 groups according to the extent of decrease in the LA volume index (LAVI) at 6 months after CA responders were those with a ≥15% reduction in the LAVI, and all others were non-responders. Results At follow-up, 58 patients (66%) were classified as responders. The preprocedural ANP level was significantly higher in the responders than in the non-responders (p=0.03). Furthermore, the ANP-to-BNP ratio (ANP/BNP) was significantly higher in the responders than in the non-responders (p<0.01). The ANP/BNP was correlated with the percentage decrease in the LAVI (r=0.391, p<0.01). A multivariate linear regression analysis revealed that the ANP/BNP before CA was an independent predictor of LA reverse remodeling (p<0.01). Conclusion The preprocedural ANP/BNP was a robust predictor of reverse remodeling of the enlarged LA after sinus rhythm restoration by rhythm control therapy in persistent AF patients.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>36823080</pmid><doi>10.2169/internalmedicine.1478-22</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Atrial Fibrillation Atrial Natriuretic Factor Atrial natriuretic peptide Brain natriuretic peptide Cardiac arrhythmia catheter ablation Enlargement Fibrillation Humans Internal medicine Linear Models Multivariate Analysis Natriuretic Peptide, Brain Original Peptides Population studies reverse remodeling |
| title | The Atrial Natriuretic Peptide-to-brain Natriuretic Peptide Ratio Predicts Left Atrial Reverse Remodeling after Rhythm Control Therapy in Patients with Persistent Atrial Fibrillation |
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