Efficacy of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor Treatment for Repeated In-stent Restenosis in a Coronary Artery
A 57-year-old woman experienced chest pain. A coronary angiogram revealed middle left anterior descending artery stenosis. Despite receiving adequate anti-hyperlipidemia treatment and undergoing percutaneous coronary intervention (PCI), she experienced angina and required PCI six more times for in-s...
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| Veröffentlicht in: | Internal Medicine 2023/11/15, Vol.62(22), pp.3361-3365 |
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| container_title | Internal Medicine |
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| creator | Akiyama, Takumi Ozaki, Kazuyuki Takano, Toshiki Yoneyama, Shintaro Kubota, Naoki Okubo, Takeshi Ikegami, Ryutaro Hoyano, Makoto Yanagawa, Takao Inomata, Takayuki |
| description | A 57-year-old woman experienced chest pain. A coronary angiogram revealed middle left anterior descending artery stenosis. Despite receiving adequate anti-hyperlipidemia treatment and undergoing percutaneous coronary intervention (PCI), she experienced angina and required PCI six more times for in-stent restenosis. As she had high lipoprotein (a) [LP-(a)] levels at the seventh PCI procedure, proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i) was administered, and a reduction in the LP-(a) and low-density lipoprotein cholesterol (LDL-C) values was observed. She experienced no recurrence of angina for five years with PCSK9i treatment. PCSK9i can reduce not only LDL-C but also LP-(a) levels, resulting in cardiac event risk reduction. |
| doi_str_mv | 10.2169/internalmedicine.1609-23 |
| format | Article |
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A coronary angiogram revealed middle left anterior descending artery stenosis. Despite receiving adequate anti-hyperlipidemia treatment and undergoing percutaneous coronary intervention (PCI), she experienced angina and required PCI six more times for in-stent restenosis. As she had high lipoprotein (a) [LP-(a)] levels at the seventh PCI procedure, proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i) was administered, and a reduction in the LP-(a) and low-density lipoprotein cholesterol (LDL-C) values was observed. She experienced no recurrence of angina for five years with PCSK9i treatment. PCSK9i can reduce not only LDL-C but also LP-(a) levels, resulting in cardiac event risk reduction.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.1609-23</identifier><identifier>PMID: 37005262</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Angina ; Case Report ; Cholesterol ; Coronary artery ; Hyperlipidemia ; Implants ; in-stent restenosis ; Internal medicine ; Kexin ; lipoprotein (a) ; Low density lipoprotein ; proprotein convertase subtilisin/kexin type 9 inhibitor ; Proprotein convertases ; Restenosis ; Subtilisin</subject><ispartof>Internal Medicine, 2023/11/15, Vol.62(22), pp.3361-3365</ispartof><rights>2023 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2023</rights><rights>Copyright © 2023 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c613t-240d380282161c2d19a873c7b9d1b4f0a92f8ba9e3eff38462a72ec15a7b112f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10713376/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10713376/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37005262$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akiyama, Takumi</creatorcontrib><creatorcontrib>Ozaki, Kazuyuki</creatorcontrib><creatorcontrib>Takano, Toshiki</creatorcontrib><creatorcontrib>Yoneyama, Shintaro</creatorcontrib><creatorcontrib>Kubota, Naoki</creatorcontrib><creatorcontrib>Okubo, Takeshi</creatorcontrib><creatorcontrib>Ikegami, Ryutaro</creatorcontrib><creatorcontrib>Hoyano, Makoto</creatorcontrib><creatorcontrib>Yanagawa, Takao</creatorcontrib><creatorcontrib>Inomata, Takayuki</creatorcontrib><title>Efficacy of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor Treatment for Repeated In-stent Restenosis in a Coronary Artery</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>A 57-year-old woman experienced chest pain. A coronary angiogram revealed middle left anterior descending artery stenosis. Despite receiving adequate anti-hyperlipidemia treatment and undergoing percutaneous coronary intervention (PCI), she experienced angina and required PCI six more times for in-stent restenosis. As she had high lipoprotein (a) [LP-(a)] levels at the seventh PCI procedure, proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i) was administered, and a reduction in the LP-(a) and low-density lipoprotein cholesterol (LDL-C) values was observed. She experienced no recurrence of angina for five years with PCSK9i treatment. PCSK9i can reduce not only LDL-C but also LP-(a) levels, resulting in cardiac event risk reduction.</description><subject>Angina</subject><subject>Case Report</subject><subject>Cholesterol</subject><subject>Coronary artery</subject><subject>Hyperlipidemia</subject><subject>Implants</subject><subject>in-stent restenosis</subject><subject>Internal medicine</subject><subject>Kexin</subject><subject>lipoprotein (a)</subject><subject>Low density lipoprotein</subject><subject>proprotein convertase subtilisin/kexin type 9 inhibitor</subject><subject>Proprotein convertases</subject><subject>Restenosis</subject><subject>Subtilisin</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNplkU1vEzEQhi0EoqHwF5AlLly29cdmvT6hKipQUamohLPl9Y4bRxt7sb0VOfPH8SohgnLxaOxnXs_MixCm5ILRRl46nyF6Peygd8Z5uKANkRXjz9CC8lpWgvHlc7QgkrYVK8cZepXSlhDeCsleojMuCFmyhi3Qr2trndFmj4PFX2MYY8jgPF4F_wgx6wT429RlN7jk_OUX-Fne1vsRsMQ3fuM6l0PE6wg678BnbEt2D2NJoS9AlfJ8ew9zDMklXMp1EY_B67jHV7HMsX-NXlg9JHhzjOfo-8fr9epzdXv36WZ1dVuZhvJcsZr0vCWsLSughvVU6lZwIzrZ0662REtm205L4GAtb-uGacHA0KUWHaXM8nP04aA7Tl3ZnCmtRT2oMbpdaUYF7dS_L95t1EN4VJQIyrloisL7o0IMP6Yyldq5ZGAYtIcwJcWErJu2dDuj756g2zDNnhVKEiqL4rIuVHugTAwpRbCnbihRs9XqqdVqtloxXkrf_j3NqfCPtwW4OwDblPUDnAAdszMD_K_cMMXYfB6_OJFmo6MCz38DOvrJ6Q</recordid><startdate>20231115</startdate><enddate>20231115</enddate><creator>Akiyama, Takumi</creator><creator>Ozaki, Kazuyuki</creator><creator>Takano, Toshiki</creator><creator>Yoneyama, Shintaro</creator><creator>Kubota, Naoki</creator><creator>Okubo, Takeshi</creator><creator>Ikegami, Ryutaro</creator><creator>Hoyano, Makoto</creator><creator>Yanagawa, Takao</creator><creator>Inomata, Takayuki</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20231115</creationdate><title>Efficacy of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor Treatment for Repeated In-stent Restenosis in a Coronary Artery</title><author>Akiyama, Takumi ; Ozaki, Kazuyuki ; Takano, Toshiki ; Yoneyama, Shintaro ; Kubota, Naoki ; Okubo, Takeshi ; Ikegami, Ryutaro ; Hoyano, Makoto ; Yanagawa, Takao ; Inomata, Takayuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c613t-240d380282161c2d19a873c7b9d1b4f0a92f8ba9e3eff38462a72ec15a7b112f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Angina</topic><topic>Case Report</topic><topic>Cholesterol</topic><topic>Coronary artery</topic><topic>Hyperlipidemia</topic><topic>Implants</topic><topic>in-stent restenosis</topic><topic>Internal medicine</topic><topic>Kexin</topic><topic>lipoprotein (a)</topic><topic>Low density lipoprotein</topic><topic>proprotein convertase subtilisin/kexin type 9 inhibitor</topic><topic>Proprotein convertases</topic><topic>Restenosis</topic><topic>Subtilisin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akiyama, Takumi</creatorcontrib><creatorcontrib>Ozaki, Kazuyuki</creatorcontrib><creatorcontrib>Takano, Toshiki</creatorcontrib><creatorcontrib>Yoneyama, Shintaro</creatorcontrib><creatorcontrib>Kubota, Naoki</creatorcontrib><creatorcontrib>Okubo, Takeshi</creatorcontrib><creatorcontrib>Ikegami, Ryutaro</creatorcontrib><creatorcontrib>Hoyano, Makoto</creatorcontrib><creatorcontrib>Yanagawa, Takao</creatorcontrib><creatorcontrib>Inomata, Takayuki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akiyama, Takumi</au><au>Ozaki, Kazuyuki</au><au>Takano, Toshiki</au><au>Yoneyama, Shintaro</au><au>Kubota, Naoki</au><au>Okubo, Takeshi</au><au>Ikegami, Ryutaro</au><au>Hoyano, Makoto</au><au>Yanagawa, Takao</au><au>Inomata, Takayuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor Treatment for Repeated In-stent Restenosis in a Coronary Artery</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2023-11-15</date><risdate>2023</risdate><volume>62</volume><issue>22</issue><spage>3361</spage><epage>3365</epage><pages>3361-3365</pages><artnum>1609-23</artnum><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>A 57-year-old woman experienced chest pain. A coronary angiogram revealed middle left anterior descending artery stenosis. Despite receiving adequate anti-hyperlipidemia treatment and undergoing percutaneous coronary intervention (PCI), she experienced angina and required PCI six more times for in-stent restenosis. As she had high lipoprotein (a) [LP-(a)] levels at the seventh PCI procedure, proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i) was administered, and a reduction in the LP-(a) and low-density lipoprotein cholesterol (LDL-C) values was observed. She experienced no recurrence of angina for five years with PCSK9i treatment. PCSK9i can reduce not only LDL-C but also LP-(a) levels, resulting in cardiac event risk reduction.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>37005262</pmid><doi>10.2169/internalmedicine.1609-23</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; PubMed Central; PubMed Central Open Access |
| subjects | Angina Case Report Cholesterol Coronary artery Hyperlipidemia Implants in-stent restenosis Internal medicine Kexin lipoprotein (a) Low density lipoprotein proprotein convertase subtilisin/kexin type 9 inhibitor Proprotein convertases Restenosis Subtilisin |
| title | Efficacy of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor Treatment for Repeated In-stent Restenosis in a Coronary Artery |
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