Association Between Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) With Diabetic Retinopathy in Type 2 Diabetic Patients
Diabetic retinopathy (DR) is one of the main causes of blindness worldwide, but an effective screening is challenging due to limited available retina specialists. Finding novel biomarkers could help clinical decision in prioritizing ophthalmological consultation in patients at risk of developing sev...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2023-11, Vol.15 (11), p.e48581-e48581 |
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| creator | Dascalu, Ana Maria Georgescu, Adriana Costea, Andreea Cristina Tribus, Laura El Youssoufi, Alae Serban, Dragos Arsene, Andreea Letitia Stana, Daniela Alexandrescu, Cristina Cristea, Bogdan Mihai Tanasescu, Denisa Bobirca, Anca Serboiu, Crenguta Alius, Catalin Bratu, Dan Georgian |
| description | Diabetic retinopathy (DR) is one of the main causes of blindness worldwide, but an effective screening is challenging due to limited available retina specialists. Finding novel biomarkers could help clinical decision in prioritizing ophthalmological consultation in patients at risk of developing severe DR. This study aims to investigate the association between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and the presence and severity of DR in patients with T2DM. A retrospective study was performed on 90 patients with T2DM admitted in the Ophthalmology Clinic, Emergency University Hospital Bucharest in Bucharest, Romania, between March 2022 and March 2023, for routine cataract surgery. The cases were divided into three groups according to the severity of DR: no DR (noDR), non-proliferative diabetic retinopathy (NPDR), and proliferative DR (PDR) groups. NLR values raised significantly in the PDR group, no DR group (p = 0.003), and NPDR group (p = 0.026), while PLR values did not differ statistically significant among the groups (p = 0.059). No difference in terms of age, sex, HbA1C, and comorbidities were observed. In the multivariate analysis, the NLR (OR = 2.01, [1.29; 3.14], p = 0.0019) and diabetic nephropathy (OR = 3.84, [1.23; 11.98], p = 0.0203) were associated with higher rates of PDR. NLR may be a promising tool in the risk stratification of T2DM patients with DR. |
| doi_str_mv | 10.7759/cureus.48581 |
| format | Article |
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Finding novel biomarkers could help clinical decision in prioritizing ophthalmological consultation in patients at risk of developing severe DR. This study aims to investigate the association between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and the presence and severity of DR in patients with T2DM. A retrospective study was performed on 90 patients with T2DM admitted in the Ophthalmology Clinic, Emergency University Hospital Bucharest in Bucharest, Romania, between March 2022 and March 2023, for routine cataract surgery. The cases were divided into three groups according to the severity of DR: no DR (noDR), non-proliferative diabetic retinopathy (NPDR), and proliferative DR (PDR) groups. NLR values raised significantly in the PDR group, no DR group (p = 0.003), and NPDR group (p = 0.026), while PLR values did not differ statistically significant among the groups (p = 0.059). No difference in terms of age, sex, HbA1C, and comorbidities were observed. In the multivariate analysis, the NLR (OR = 2.01, [1.29; 3.14], p = 0.0019) and diabetic nephropathy (OR = 3.84, [1.23; 11.98], p = 0.0203) were associated with higher rates of PDR. NLR may be a promising tool in the risk stratification of T2DM patients with DR.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.48581</identifier><identifier>PMID: 38090430</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Biomarkers ; Blood platelets ; Blood tests ; Cataracts ; Creatinine ; Diabetes ; Diabetic nephropathy ; Diabetic retinopathy ; Hypertension ; Lymphocytes ; Medical prognosis ; Neutrophils ; Ophthalmology ; Variance analysis ; Visual impairment</subject><ispartof>Curēus (Palo Alto, CA), 2023-11, Vol.15 (11), p.e48581-e48581</ispartof><rights>Copyright © 2023, Dascalu et al.</rights><rights>Copyright © 2023, Dascalu et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2023, Dascalu et al. 2023 Dascalu et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c343t-32d4737a61b1b9eb5411f6ab02b527d5afafe390199caa440a2d8647b2d6693e3</citedby><cites>FETCH-LOGICAL-c343t-32d4737a61b1b9eb5411f6ab02b527d5afafe390199caa440a2d8647b2d6693e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10711340/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10711340/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38090430$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dascalu, Ana Maria</creatorcontrib><creatorcontrib>Georgescu, Adriana</creatorcontrib><creatorcontrib>Costea, Andreea Cristina</creatorcontrib><creatorcontrib>Tribus, Laura</creatorcontrib><creatorcontrib>El Youssoufi, Alae</creatorcontrib><creatorcontrib>Serban, Dragos</creatorcontrib><creatorcontrib>Arsene, Andreea Letitia</creatorcontrib><creatorcontrib>Stana, Daniela</creatorcontrib><creatorcontrib>Alexandrescu, Cristina</creatorcontrib><creatorcontrib>Cristea, Bogdan Mihai</creatorcontrib><creatorcontrib>Tanasescu, Denisa</creatorcontrib><creatorcontrib>Bobirca, Anca</creatorcontrib><creatorcontrib>Serboiu, Crenguta</creatorcontrib><creatorcontrib>Alius, Catalin</creatorcontrib><creatorcontrib>Bratu, Dan Georgian</creatorcontrib><title>Association Between Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) With Diabetic Retinopathy in Type 2 Diabetic Patients</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Diabetic retinopathy (DR) is one of the main causes of blindness worldwide, but an effective screening is challenging due to limited available retina specialists. Finding novel biomarkers could help clinical decision in prioritizing ophthalmological consultation in patients at risk of developing severe DR. This study aims to investigate the association between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and the presence and severity of DR in patients with T2DM. A retrospective study was performed on 90 patients with T2DM admitted in the Ophthalmology Clinic, Emergency University Hospital Bucharest in Bucharest, Romania, between March 2022 and March 2023, for routine cataract surgery. The cases were divided into three groups according to the severity of DR: no DR (noDR), non-proliferative diabetic retinopathy (NPDR), and proliferative DR (PDR) groups. NLR values raised significantly in the PDR group, no DR group (p = 0.003), and NPDR group (p = 0.026), while PLR values did not differ statistically significant among the groups (p = 0.059). No difference in terms of age, sex, HbA1C, and comorbidities were observed. 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Finding novel biomarkers could help clinical decision in prioritizing ophthalmological consultation in patients at risk of developing severe DR. This study aims to investigate the association between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and the presence and severity of DR in patients with T2DM. A retrospective study was performed on 90 patients with T2DM admitted in the Ophthalmology Clinic, Emergency University Hospital Bucharest in Bucharest, Romania, between March 2022 and March 2023, for routine cataract surgery. The cases were divided into three groups according to the severity of DR: no DR (noDR), non-proliferative diabetic retinopathy (NPDR), and proliferative DR (PDR) groups. NLR values raised significantly in the PDR group, no DR group (p = 0.003), and NPDR group (p = 0.026), while PLR values did not differ statistically significant among the groups (p = 0.059). No difference in terms of age, sex, HbA1C, and comorbidities were observed. In the multivariate analysis, the NLR (OR = 2.01, [1.29; 3.14], p = 0.0019) and diabetic nephropathy (OR = 3.84, [1.23; 11.98], p = 0.0203) were associated with higher rates of PDR. NLR may be a promising tool in the risk stratification of T2DM patients with DR.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>38090430</pmid><doi>10.7759/cureus.48581</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Biomarkers Blood platelets Blood tests Cataracts Creatinine Diabetes Diabetic nephropathy Diabetic retinopathy Hypertension Lymphocytes Medical prognosis Neutrophils Ophthalmology Variance analysis Visual impairment |
| title | Association Between Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) With Diabetic Retinopathy in Type 2 Diabetic Patients |
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