Does the expression of granzyme B participate in inflammation, fibrosis, and fertility of hydatid cysts?
Echinococcus granulosus (sensu lato), a cestode that is endemic in Egypt, causes cystic echinococcosis (CE), a significant but neglected zoonotic disease that is prevalent throughout the world. Infected hydatid cysts are classified as fertile or non-fertile based on the presence of protoscoleces; ne...
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| container_title | Parasitology research (1987) |
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| creator | Sweed, Dina Mohamady, Mohamed Gouda, Marwa A. Fayed, Yahya Saied, Sara A. Elhamed, Sara M. Abd |
| description | Echinococcus
granulosus
(sensu lato), a cestode that is endemic in Egypt, causes cystic echinococcosis (CE), a significant but neglected zoonotic disease that is prevalent throughout the world. Infected hydatid cysts are classified as fertile or non-fertile based on the presence of protoscoleces; nevertheless, the mechanism of non-fertile CE cysts remains unknown. The study aimed to assess whether granzyme B (GrB) expression and CD4 + /CD8 + could be related to the induction of non-fertile CE cysts. A total of fifty-eight individuals diagnosed with visceral hydatid cysts were selected, and they were further divided according to cyst fertility into fertile and non-fertile. Immunohistochemistry for CD4, CD8, and GrB was done. According to the results, hydatid cysts are common in adults and have no gender preference. The same clinical and laboratory data were shared by patients with fertile and non-fertile cysts (
p
= 0.186). GrB expression was not impacted by the fibrous deposition inside the hydatid cyst wall (
p
= 0.85); however, GrB was significantly correlated with the inflammatory density (
p
= 0.005). GrB expression was also found to be significantly higher in non-fertile cysts (
p
= 0.04). GrB expression is positively correlated with CD4 and CD8 expression. In conclusion, the expression of GrB in hydatid cysts may exacerbate the inflammatory response and impede cyst fertility while not affecting the fibrous deposition in the cyst wall. |
| doi_str_mv | 10.1007/s00436-023-08056-2 |
| format | Article |
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granulosus
(sensu lato), a cestode that is endemic in Egypt, causes cystic echinococcosis (CE), a significant but neglected zoonotic disease that is prevalent throughout the world. Infected hydatid cysts are classified as fertile or non-fertile based on the presence of protoscoleces; nevertheless, the mechanism of non-fertile CE cysts remains unknown. The study aimed to assess whether granzyme B (GrB) expression and CD4 + /CD8 + could be related to the induction of non-fertile CE cysts. A total of fifty-eight individuals diagnosed with visceral hydatid cysts were selected, and they were further divided according to cyst fertility into fertile and non-fertile. Immunohistochemistry for CD4, CD8, and GrB was done. According to the results, hydatid cysts are common in adults and have no gender preference. The same clinical and laboratory data were shared by patients with fertile and non-fertile cysts (
p
= 0.186). GrB expression was not impacted by the fibrous deposition inside the hydatid cyst wall (
p
= 0.85); however, GrB was significantly correlated with the inflammatory density (
p
= 0.005). GrB expression was also found to be significantly higher in non-fertile cysts (
p
= 0.04). GrB expression is positively correlated with CD4 and CD8 expression. In conclusion, the expression of GrB in hydatid cysts may exacerbate the inflammatory response and impede cyst fertility while not affecting the fibrous deposition in the cyst wall.</description><identifier>ISSN: 0932-0113</identifier><identifier>ISSN: 1432-1955</identifier><identifier>EISSN: 1432-1955</identifier><identifier>DOI: 10.1007/s00436-023-08056-2</identifier><identifier>PMID: 38072840</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; B cells ; Biomedical and Life Sciences ; Biomedicine ; CD4 antigen ; CD8 antigen ; Cysts ; Echinococcosis ; Echinococcosis - epidemiology ; Echinococcus ; Echinococcus granulosus ; Echinococcus granulosus - physiology ; Egypt ; Ethylenediaminetetraacetic acid ; Fertility ; Fibrosis ; gender ; Granzyme B ; Granzymes ; Health aspects ; Humans ; Immunohistochemistry ; Immunology ; Inflammation ; Medical Microbiology ; Microbiology ; protoscoleces ; Zoonoses</subject><ispartof>Parasitology research (1987), 2024-01, Vol.123 (1), p.22-22, Article 22</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>COPYRIGHT 2024 Springer</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c526t-f3852ffd1c022f71f1ade9a7b4fb817f77250ab1d8901fb89897b200d66e255d3</cites><orcidid>0000-0001-6483-5056 ; 0009-0009-8183-7868 ; 0000-0003-1723-6792 ; 0000-0003-0526-2627</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00436-023-08056-2$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00436-023-08056-2$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38072840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sweed, Dina</creatorcontrib><creatorcontrib>Mohamady, Mohamed</creatorcontrib><creatorcontrib>Gouda, Marwa A.</creatorcontrib><creatorcontrib>Fayed, Yahya</creatorcontrib><creatorcontrib>Saied, Sara A.</creatorcontrib><creatorcontrib>Elhamed, Sara M. Abd</creatorcontrib><title>Does the expression of granzyme B participate in inflammation, fibrosis, and fertility of hydatid cysts?</title><title>Parasitology research (1987)</title><addtitle>Parasitol Res</addtitle><addtitle>Parasitol Res</addtitle><description>Echinococcus
granulosus
(sensu lato), a cestode that is endemic in Egypt, causes cystic echinococcosis (CE), a significant but neglected zoonotic disease that is prevalent throughout the world. Infected hydatid cysts are classified as fertile or non-fertile based on the presence of protoscoleces; nevertheless, the mechanism of non-fertile CE cysts remains unknown. The study aimed to assess whether granzyme B (GrB) expression and CD4 + /CD8 + could be related to the induction of non-fertile CE cysts. A total of fifty-eight individuals diagnosed with visceral hydatid cysts were selected, and they were further divided according to cyst fertility into fertile and non-fertile. Immunohistochemistry for CD4, CD8, and GrB was done. According to the results, hydatid cysts are common in adults and have no gender preference. The same clinical and laboratory data were shared by patients with fertile and non-fertile cysts (
p
= 0.186). GrB expression was not impacted by the fibrous deposition inside the hydatid cyst wall (
p
= 0.85); however, GrB was significantly correlated with the inflammatory density (
p
= 0.005). GrB expression was also found to be significantly higher in non-fertile cysts (
p
= 0.04). GrB expression is positively correlated with CD4 and CD8 expression. In conclusion, the expression of GrB in hydatid cysts may exacerbate the inflammatory response and impede cyst fertility while not affecting the fibrous deposition in the cyst wall.</description><subject>Animals</subject><subject>B cells</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>CD4 antigen</subject><subject>CD8 antigen</subject><subject>Cysts</subject><subject>Echinococcosis</subject><subject>Echinococcosis - epidemiology</subject><subject>Echinococcus</subject><subject>Echinococcus granulosus</subject><subject>Echinococcus granulosus - physiology</subject><subject>Egypt</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Fertility</subject><subject>Fibrosis</subject><subject>gender</subject><subject>Granzyme B</subject><subject>Granzymes</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Immunology</subject><subject>Inflammation</subject><subject>Medical Microbiology</subject><subject>Microbiology</subject><subject>protoscoleces</subject><subject>Zoonoses</subject><issn>0932-0113</issn><issn>1432-1955</issn><issn>1432-1955</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNqFkk9vFSEUxSdGY5_VL-DCkLhx0akXGAZYNbX-TZq40TVhBniPZgZGmGccP72Mr7bWGA0kkMvvnsDhVNVTDKcYgL_MAA1tayC0BgGsrcm9aoMbSmosGbtfbUCWPWBMj6pHOV8BYN42zcPqiArgRDSwqXavo81o3llkv03J5uxjQNGhbdLh-zJa9ApNOs2-95OeLfKhTDfocdRzIU-Q812K2ecTpINBzhZ08POySuwWUyCD-iXP-exx9cDpIdsn1-tx9fntm08X7-vLj-8-XJxf1j0j7Vw7KhhxzuAeCHEcO6yNlZp3jesE5o5zwkB32AgJuJSkkLwjAKZtLWHM0OPq7KA77bvRmt6GOelBTcmPOi0qaq_ungS_U9v4VWHgGGTLi8KLa4UUv-xtntXoc2-HQQcb91lRzChrhRD_R4kEIulqekGf_4FexX0KxYqVAorLQ9pbaqsHq4rVsdyxX0XVOedMNhgzUajTv1BlGDv6PgbrfKnfaSCHhr58Vk7W3fiBQa1ZUocsqZIl9TNLipSmZ787edPyKzwFoAcgl6Owten2Sf-Q_QGrONOO</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Sweed, Dina</creator><creator>Mohamady, Mohamed</creator><creator>Gouda, Marwa A.</creator><creator>Fayed, Yahya</creator><creator>Saied, Sara A.</creator><creator>Elhamed, Sara M. Abd</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6483-5056</orcidid><orcidid>https://orcid.org/0009-0009-8183-7868</orcidid><orcidid>https://orcid.org/0000-0003-1723-6792</orcidid><orcidid>https://orcid.org/0000-0003-0526-2627</orcidid></search><sort><creationdate>20240101</creationdate><title>Does the expression of granzyme B participate in inflammation, fibrosis, and fertility of hydatid cysts?</title><author>Sweed, Dina ; Mohamady, Mohamed ; Gouda, Marwa A. ; Fayed, Yahya ; Saied, Sara A. ; Elhamed, Sara M. Abd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-f3852ffd1c022f71f1ade9a7b4fb817f77250ab1d8901fb89897b200d66e255d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>B cells</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>CD4 antigen</topic><topic>CD8 antigen</topic><topic>Cysts</topic><topic>Echinococcosis</topic><topic>Echinococcosis - epidemiology</topic><topic>Echinococcus</topic><topic>Echinococcus granulosus</topic><topic>Echinococcus granulosus - physiology</topic><topic>Egypt</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Fertility</topic><topic>Fibrosis</topic><topic>gender</topic><topic>Granzyme B</topic><topic>Granzymes</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Immunology</topic><topic>Inflammation</topic><topic>Medical Microbiology</topic><topic>Microbiology</topic><topic>protoscoleces</topic><topic>Zoonoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sweed, Dina</creatorcontrib><creatorcontrib>Mohamady, Mohamed</creatorcontrib><creatorcontrib>Gouda, Marwa A.</creatorcontrib><creatorcontrib>Fayed, Yahya</creatorcontrib><creatorcontrib>Saied, Sara A.</creatorcontrib><creatorcontrib>Elhamed, Sara M. Abd</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Parasitology research (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sweed, Dina</au><au>Mohamady, Mohamed</au><au>Gouda, Marwa A.</au><au>Fayed, Yahya</au><au>Saied, Sara A.</au><au>Elhamed, Sara M. Abd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does the expression of granzyme B participate in inflammation, fibrosis, and fertility of hydatid cysts?</atitle><jtitle>Parasitology research (1987)</jtitle><stitle>Parasitol Res</stitle><addtitle>Parasitol Res</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>123</volume><issue>1</issue><spage>22</spage><epage>22</epage><pages>22-22</pages><artnum>22</artnum><issn>0932-0113</issn><issn>1432-1955</issn><eissn>1432-1955</eissn><abstract>Echinococcus
granulosus
(sensu lato), a cestode that is endemic in Egypt, causes cystic echinococcosis (CE), a significant but neglected zoonotic disease that is prevalent throughout the world. Infected hydatid cysts are classified as fertile or non-fertile based on the presence of protoscoleces; nevertheless, the mechanism of non-fertile CE cysts remains unknown. The study aimed to assess whether granzyme B (GrB) expression and CD4 + /CD8 + could be related to the induction of non-fertile CE cysts. A total of fifty-eight individuals diagnosed with visceral hydatid cysts were selected, and they were further divided according to cyst fertility into fertile and non-fertile. Immunohistochemistry for CD4, CD8, and GrB was done. According to the results, hydatid cysts are common in adults and have no gender preference. The same clinical and laboratory data were shared by patients with fertile and non-fertile cysts (
p
= 0.186). GrB expression was not impacted by the fibrous deposition inside the hydatid cyst wall (
p
= 0.85); however, GrB was significantly correlated with the inflammatory density (
p
= 0.005). GrB expression was also found to be significantly higher in non-fertile cysts (
p
= 0.04). GrB expression is positively correlated with CD4 and CD8 expression. In conclusion, the expression of GrB in hydatid cysts may exacerbate the inflammatory response and impede cyst fertility while not affecting the fibrous deposition in the cyst wall.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38072840</pmid><doi>10.1007/s00436-023-08056-2</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-6483-5056</orcidid><orcidid>https://orcid.org/0009-0009-8183-7868</orcidid><orcidid>https://orcid.org/0000-0003-1723-6792</orcidid><orcidid>https://orcid.org/0000-0003-0526-2627</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Parasitology research (1987), 2024-01, Vol.123 (1), p.22-22, Article 22 |
| issn | 0932-0113 1432-1955 1432-1955 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Animals B cells Biomedical and Life Sciences Biomedicine CD4 antigen CD8 antigen Cysts Echinococcosis Echinococcosis - epidemiology Echinococcus Echinococcus granulosus Echinococcus granulosus - physiology Egypt Ethylenediaminetetraacetic acid Fertility Fibrosis gender Granzyme B Granzymes Health aspects Humans Immunohistochemistry Immunology Inflammation Medical Microbiology Microbiology protoscoleces Zoonoses |
| title | Does the expression of granzyme B participate in inflammation, fibrosis, and fertility of hydatid cysts? |
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