High-throughput screening of glucocorticoid-induced enhancer activity reveals mechanisms of stress-related psychiatric disorders

Exposure to stressful life events increases the risk for psychiatric disorders. Mechanistic insight into the genetic factors moderating the impact of stress can increase our understanding of disease processes. Here, we test 3,662 single nucleotide polymorphisms (SNPs) from preselected expression qua...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-12, Vol.120 (49), p.e2305773120-e2305773120
Hauptverfasser:	Penner-Goeke, Signe, Bothe, Melissa, Rek, Nils, Kreitmaier, Peter, Pöhlchen, Dorothee, Kühnel, Anne, Glaser, Laura V, Kaya, Ezgi, Krontira, Anthi C, Röh, Simone, Czamara, Darina, Ködel, Maik, Monteserin-Garcia, Jose, Diener, Laura, Wölfel, Barbara, Sauer, Susann, Rummel, Christine, Riesenberg, Stephan, Arloth-Knauer, Janine, Ziller, Michael, Labeur, Marta, Meijsing, Sebastiaan, Binder, Elisabeth B
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Disorders Gene mapping Genetic diversity Genetic factors Genetic Predisposition to Disease Genetic variance Genome-Wide Association Study Glucocorticoids Health risks High-throughput screening High-Throughput Screening Assays Humans Mental disorders Mental Disorders - genetics Nucleotides Phenotypes Polymorphism, Single Nucleotide Quantitative Trait Loci Regulatory sequences Regulatory Sequences, Nucleic Acid Single-nucleotide polymorphism Stress (physiology) Stress response
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