MAF amplification licenses ERα through epigenetic remodelling to drive breast cancer metastasis

MAF amplification increases the risk of breast cancer (BCa) metastasis through mechanisms that are still poorly understood yet have important clinical implications. Oestrogen-receptor-positive (ER + ) BCa requires oestrogen for both growth and metastasis, albeit by ill-known mechanisms. Here we inte...

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Veröffentlicht in:	Nature cell biology 2023-12, Vol.25 (12), p.1833-1847
Hauptverfasser:	Llorente, Alicia, Blasco, María Teresa, Espuny, Irene, Guiu, Marc, Ballaré, Cecilia, Blanco, Enrique, Caballé, Adrià, Bellmunt, Anna, Salvador, Fernando, Morales, Andrea, Nuñez, Marc, Loren, Guillem, Imbastari, Francesca, Fidalgo, Marta, Figueras-Puig, Cristina, Gibler, Patrizia, Graupera, Mariona, Monteiro, Freddy, Riera, Antoni, Holen, Ingunn, Avgustinova, Alexandra, Di Croce, Luciano, Gomis, Roger R.
Format:	Artikel
Sprache:	eng
Schlagworte:	14/19 38/39 38/91 45/15 59/5 631/67/1347 631/67/322 631/67/68/2486 64/60 82/58 Amplification Animal models Animals Biomedical and Life Sciences Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Research Cell Biology Cell Line, Tumor Chromatin Developmental Biology Epigenesis, Genetic Epigenetics Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogen receptors Estrogens Female Gene Amplification Gene expression Genes Histone Demethylases - genetics Histone Demethylases - metabolism Histones Humans Life Sciences Metastases Metastasis Mice Proteomics Proto-Oncogene Proteins c-maf - genetics Receptors Stem Cells Transcriptomics
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