Characterization of the gene cassette required for biosynthesis of the (alpha1-->6)-linked N-acetyl-D-mannosamine-1-phosphate capsule of serogroup A Neisseria meningitidis

The (alpha1-->6)-linked N-acetyl-D-mannosamine-1-phosphate meningococcal capsule of serogroup A Neisseria meningitidis is biochemically distinct from the sialic acid-containing capsules produced by other disease-associated meningococcal serogroups (e.g., B, C, Y, and W-135). We defined the geneti...

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Veröffentlicht in:	Journal of bacteriology 1998-03, Vol.180 (6), p.1533-1539
Hauptverfasser:	Swartley, J S, Liu, L J, Miller, Y K, Martin, L E, Edupuganti, S, Stephens, D S
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Capsules - biosynthesis Bacterial Capsules - genetics Bacterial Capsules - immunology Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Base Sequence Carbohydrate Epimerases - genetics Carbohydrate Epimerases - metabolism Cell Surfaces Chromosomes, Bacterial Cloning, Molecular DNA, Bacterial - analysis DNA, Bacterial - genetics DNA-Binding Proteins Escherichia coli Proteins Genes Genes, Bacterial Hexosamines - biosynthesis Hexosamines - genetics Hexosamines - immunology Immunoblotting Molecular Sequence Data Mutagenesis, Insertional Neisseria meningitidis - genetics Neisseria meningitidis - immunology Neisseria meningitidis - metabolism Open Reading Frames Operon Plasmids Polymerase Chain Reaction Promoter Regions, Genetic RNA, Messenger - analysis RNA, Messenger - metabolism Sequence Analysis, DNA Transcription Factors Transcription, Genetic Transformation, Genetic UDPglucose 4-Epimerase - genetics UDPglucose 4-Epimerase - metabolism Uridine Diphosphate N-Acetylglucosamine - metabolism Uridine Diphosphate Sugars - metabolism
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