Ikaros integrates endocrine and immune system development

Ikaros transcription factors are essential regulators of lymphopoiesis and the development of the immune system. We now show that Ikaros is expressed in hormone-producing pituitary corticomelanotroph cells, where it binds the proopiomelanocortin promoter and regulates endogenous gene expression. Los...

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Veröffentlicht in:	The Journal of clinical investigation 2005-04, Vol.115 (4), p.1021-1029
Hauptverfasser:	Ezzat, Shereen, Mader, Rene, Yu, ShunJiang, Ning, Terry, Poussier, Philippe, Asa, Sylvia L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic Hormone - genetics Adrenocorticotropic Hormone - metabolism Animals Antibodies Base Sequence Binding Sites Biomedical research Carrier Proteins - genetics Carrier Proteins - metabolism Cells, Cultured DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Endocrine System - growth & development Endocrine System - metabolism Fibroblasts Gene expression Gene Expression Regulation Growth factors Humans Hypothalamo-Hypophyseal System - physiology Ikaros Transcription Factor Immune system Immune System - growth & development Immune System - metabolism Lymphocytes Mice Mice, Inbred C57BL Mice, Knockout Molecular Sequence Data Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Pituitary Gland - cytology Pituitary Gland - metabolism Pituitary-Adrenal System - physiology Pro-Opiomelanocortin - genetics Pro-Opiomelanocortin - metabolism Promoter Regions, Genetic Proteins Survival Rate Transcription Factors - genetics Transcription Factors - metabolism
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