Breast adipose tissue‐derived extracellular vesicles from obese women alter tumor cell metabolism

Breast adipose tissue is an important contributor to the obesity–breast cancer link. Extracellular vesicles (EVs) are nanosized particles containing selective cargo, such as miRNAs, that act locally or circulate to distant sites to modulate target cell functions. Here, we find that long‐term educati...

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Veröffentlicht in:	EMBO reports 2023-12, Vol.24 (12), p.e57339-n/a
Hauptverfasser:	Liu, Shuchen, Benito‐Martin, Alberto, Pelissier Vatter, Fanny A, Hanif, Sarah Z, Liu, Catherine, Bhardwaj, Priya, Sethupathy, Praveen, Farghli, Alaa R, Piloco, Phoebe, Paik, Paul, Mushannen, Malik, Dong, Xue, Otterburn, David M, Cohen, Leslie, Bareja, Rohan, Krumsiek, Jan, Cohen‐Gould, Leona, Calto, Samuel, Spector, Jason A, Elemento, Olivier, Lyden, David C, Brown, Kristy A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adipose Tissue - metabolism AKT protein ATP synthase Body fat Body weight Breast cancer Breast Neoplasms - metabolism Cell proliferation Density Education Electron transport chain Enrichment Extracellular vesicles Extracellular Vesicles - metabolism Female Gene expression Humans Metformin MicroRNAs - genetics MicroRNAs - metabolism Mitochondria mitochondrial respiration NADH-ubiquinone oxidoreductase Nicotinamide adenine dinucleotide Obesity Obesity - metabolism Overweight Oxidative phosphorylation Phosphorylation proliferation Proteins - metabolism Respiration Ribosomal Protein S6 Kinases, 70-kDa - metabolism TOR protein Tumor cells Tumors Ubiquinone oxidoreductase Vesicles
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