Relationship of the 1846G > A Polymorphism of the CYP2D6 Gene to the Equilibrium Concentration Levels of Haloperidol in Patients with Acute Alcoholic Hallucinosis

Haloperidol is currently used in addictology for the treatment of acute psychotic disorders, including acute alcoholic hallucinosis. The use of haloperidol is often accompanied by the occurrence of adverse drug reactions (ADRs). There is evidence that CYP2D6 isoenzyme is involved in the biotransform...

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Veröffentlicht in:	Psychopharmacology bulletin 2023-12, Vol.53 (4), p.15-22
Hauptverfasser:	Parkhomenko, A A, Zastrozhin, M S, Skryabin, VYu, Petukhov, A E, Pozdniakov, S A, Ivanchenko, V A, Zaytsev, I A, Bure, I V, Bochkov, P O, Akmalova, K A, Smirnov, V V, Bryun, E A, Sychev, D A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alcohol Withdrawal Delirium - drug therapy Antipsychotic Agents - pharmacokinetics Antipsychotic Agents - therapeutic use Cytochrome P-450 CYP2D6 - genetics Cytochrome P-450 CYP2D6 - metabolism Genotype Haloperidol - adverse effects Haloperidol - pharmacokinetics Haloperidol - therapeutic use Humans Male Middle Aged Original Research Psychotic Disorders - drug therapy Tandem Mass Spectrometry
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