Design of stimulus-responsive two-state hinge proteins

In nature, proteins that switch between two conformations in response to environmental stimuli structurally transduce biochemical information in a manner analogous to how transistors control information flow in computing devices. Designing proteins with two distinct but fully structured conformation...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2023-08, Vol.381 (6659), p.754-760
Hauptverfasser:	Praetorius, Florian, Leung, Philip J. Y., Tessmer, Maxx H., Broerman, Adam, Demakis, Cullen, Dishman, Acacia F., Pillai, Arvind, Idris, Abbas, Juergens, David, Dauparas, Justas, Li, Xinting, Levine, Paul M., Lamb, Mila, Ballard, Ryanne K., Gerben, Stacey R., Nguyen, Hannah, Kang, Alex, Sankaran, Banumathi, Bera, Asim K., Volkman, Brian F., Nivala, Jeff, Stoll, Stefan, Baker, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Proteins Science & Technology - Other Topics Switches
Online-Zugang:	Volltext
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