Polygenic Risk Score-Based Association Analysis of Speech-in-Noise and Hearing Threshold Measures in Healthy Young Adults with Self-reported Normal Hearing

Purpose Speech-in-noise (SIN) traits exhibit high inter-subject variability, even for healthy young adults reporting normal hearing. Emerging evidence suggests that genetic variability could influence inter-subject variability in SIN traits. Genome-wide association studies (GWAS) have uncovered the...

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Veröffentlicht in:	Journal of the Association for Research in Otolaryngology 2023-10, Vol.24 (5), p.513-525
Hauptverfasser:	Bhatt, Ishan Sunilkumar, Ramadugu, Sai Kumar, Goodman, Shawn, Bhagavan, Srividya Grama, Ingalls, Valerie, Dias, Raquel, Torkamani, Ali
Format:	Artikel
Sprache:	eng
Schlagworte:	Association analysis Cholesterol Dementia disorders Genetic variability Genome-wide association studies Genome-Wide Association Study Genomes Hearing Hearing loss High density lipoprotein Humans Medicine Medicine & Public Health Neurobiology Neurosciences Original : General Research Original Article: General Research Otorhinolaryngology Polygenic inheritance Risk Factors Saliva Self Report Speech Speech Perception Whole genome sequencing Young Adult Young adults
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